Search Results - "Lehrer, Robert I."

Inerolysin, a Cholesterol-Dependent Cytolysin Produced by Lactobacillus iners by RAMPERSAUD, Ryan, PLANET, Paul J, RANDIS, Tara M, KULKARNI, Ritwij, AGUILAR, Jorge L, LEHRER, Robert I, RATNER, Adam J

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Antibacterial Activity and Specificity of the Six Human α-Defensins by ERICKSEN, Bryan, ZHIBIN WU, WUYUAN LU, LEHRER, Robert I

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Membrane-Dependent Oligomeric Structure and Pore Formation of a β-Hairpin Antimicrobial Peptide in Lipid Bilayers from Solid-State NMR by Mani, Rajeswari, Cady, Sarah D., Tang, Ming, Waring, Alan J., Lehrer, Robert I., Hong, Mei

“…We used solid-state NMR spectroscopy to investigate the oligomeric structure and insertion of protegrin-1 (PG-1), a β-hairpin antimicrobial peptide, in lipid…”
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Anti-inflammatory apoA-I-mimetic peptides bind oxidized lipids with much higher affinity than human apoA-I by Van Lenten, Brian J., Wagner, Alan C., Jung, Chun-Ling, Ruchala, Piotr, Waring, Alan J., Lehrer, Robert I., Watson, Andrew D., Hama, Susan, Navab, Mohamad, Anantharamaiah, G.M., Fogelman, Alan M.

“…4F is an anti-inflammatory, apolipoprotein A-I (apoA-I)-mimetic peptide that is active in vivo at nanomolar concentrations in the presence of a large molar…”
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Through the Looking Glass, Mechanistic Insights from Enantiomeric Human Defensins by Wei, Gang, de Leeuw, Erik, Pazgier, Marzena, Yuan, Weirong, Zou, Guozhang, Wang, Jianfeng, Ericksen, Bryan, Lu, Wei-Yue, Lehrer, Robert I., Lu, Wuyuan

“…Despite the small size and conserved tertiary structure of defensins, little is known at a molecular level about the basis of their functional versatility. For…”
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Induction of group A Streptococcus virulence by a human antimicrobial peptide by Gryllos, Ioannis, Tran-Winkler, Hien J, Cheng, Ming-Fang, Chung, Hachung, Bolcome, Robert III, Lu, Wuyuan, Lehrer, Robert I, Wessels, Michael R

“…Group A streptococci (Streptococcus pyogenes or GAS) freshly isolated from individuals with streptococcal sore throat or invasive ("flesh-eating") infection…”
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α-Defensins in human innate immunity by Lehrer, Robert I., Lu, Wuyuan

“…Defensins are small, multifunctional cationic peptides. They typically contain six conserved cysteines whose three intramolecular disulfides stabilize a…”
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α-Defensin Inhibits Influenza Virus Replication by Cell-Mediated Mechanism(s) by Salvatore, Mirella, García-Sastre, Adolfo, Ruchala, Piotr, Lehrer, Robert I., Chang, Theresa, Klotman, Mary E.

“…The innate immune system mounts the first host response to pathogens. Because α-defensins, which are cationic antimicrobial peptides of polymorphonuclear…”
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Antimicrobial mechanism of pore-forming protegrin peptides: 100 pores to kill E. coli by Bolintineanu, Dan, Hazrati, Ehsan, Davis, H. Ted, Lehrer, Robert I., Kaznessis, Yiannis N.

“…Antimicrobial peptides (AMPs), important effector molecules of the innate immune system, also provide templates for designing novel antibiotics. Protegrin, an…”
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Effects of Guanidinium-Phosphate Hydrogen Bonding on the Membrane-Bound Structure and Activity of an Arginine-Rich Membrane Peptide from Solid-State NMR Spectroscopy by Tang, Ming, Waring, Alan J, Lehrer, Robert I, Hong, Mei

“…Barreling through: Guanidinium–phosphate hydrogen bonding significantly affects the structure and activity of the antimicrobial peptide PG‐1. Solid‐state NMR…”
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Carbohydrate-binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteins by Chernomordik, Leonid V, Leikina, Eugenia, Delanoe-Ayari, Helene, Melikov, Kamran, Cho, Myoung-Soon, Chen, Andrew, Waring, Alan J, Wang, Wei, Xie, Yongming, Loo, Joseph A, Lehrer, Robert I

“…Defensins are peptides that protect the host against microorganisms. Here we show that the theta-defensin retrocyclin 2 (RC2) inhibited influenza virus…”
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Reawakening retrocyclins: ancestral human defensins active against HIV-1 by Venkataraman, Nitya, Cole, Amy L, Ruchala, Piotr, Waring, Alan J, Lehrer, Robert I, Stuchlik, Olga, Pohl, Jan, Cole, Alexander M

“…Human alpha and beta defensins contribute substantially to innate immune defenses against microbial and viral infections. Certain nonhuman primates also…”
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Cathelicidins: a family of endogenous antimicrobial peptides by Lehrer, Robert I, Ganz, Tomas

“…The cytoplasmic granules of mammalian neutrophils contain several antimicrobial peptides. Some, like defensins, are fully processed before storage, whereas…”
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θ Defensins Protect Cells from Infection by Herpes Simplex Virus by Inhibiting Viral Adhesion and Entry by Yasin, Bushra, Wang, Wei, Pang, Mabel, Cheshenko, Natalia, Hong, Teresa, Waring, Alan J, Herold, Betsy C, Wagar, Elizabeth A, Lehrer, Robert I

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Crystallization of Antimicrobial Pores in Membranes: Magainin and Protegrin by Yang, Lin, Weiss, Thomas M., Lehrer, Robert I., Huang, Huey W.

“…Membrane pores spontaneously formed by antimicrobial peptides in membranes were crystallized for the first time by manipulating the sample hydration and…”
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A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids by Navab, Mohamad, Ruchala, Piotr, Waring, Alan J., Lehrer, Robert I., Hama, Susan, Hough, Greg, Palgunachari, Mayakonda N., Anantharamaiah, G.M., Fogelman, Alan M.

“…Administered subcutaneously, D-4F or L-4F are equally efficacious, but only D-4F is orally efficacious because of digestion of L-4F by gut proteases. Orally…”
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Activities of LL-37, a Cathelin-Associated Antimicrobial Peptide of Human Neutrophils by Turner, J, Cho, Y, Dinh, N N, Waring, A J, Lehrer, R I

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Retrocyclin: A Primate Peptide That Protects Cells from Infection by T- and M-Tropic Strains of HIV-1 by Cole, Alexander M., Hong, Teresa, Boo, Lee Ming, Nguyen, Tung, Zhao, Chengquan, Bristol, Greg, Zack, Jerome A., Waring, Alan J., Yang, Otto O., Lehrer, Robert I.

“…Human bone marrow expresses a pseudogene that encodes an antimicrobial peptide homologous to rhesus monkey circular minidefensins (θ-defensins). We prepared…”
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Interaction of Antimicrobial Peptide Protegrin with Biomembranes by Gidalevitz, David, Ishitsuka, Yuji, Muresan, Adrian S., Konovalov, Oleg, Waring, Alan J., Lehrer, Robert I., Ka Yee C. Lee

“…The antimicrobial peptide protegrin-1 (PG-1) interacts with membranes in a manner that strongly depends on membrane lipid composition. In this research we use…”
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Retrocyclins Kill Bacilli and Germinating Spores of Bacillus anthracis and Inactivate Anthrax Lethal Toxin by Wang, Wei, Mulakala, Chandrika, Ward, Sabrina C., Jung, Grace, Luong, Hai, Pham, Duy, Waring, Alan J., Kaznessis, Yiannis, Lu, Wuyuan, Bradley, Kenneth A., Lehrer, Robert I.

“…θ-defensins are cyclic octadecapeptides encoded by the modified α-defensin genes of certain nonhuman primates. The recent demonstration that human α-defensins…”
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