Search Results - "Lehrer, Douglas"

Daily oral dosing of vitamin D3 using 5000 TO 50,000 international units a day in long-term hospitalized patients: Insights from a seven year experience by McCullough, Patrick J., Lehrer, Douglas S., Amend, Jeffrey

“…•Daily dosing with vitamin D ranged from 5000 IU/day to 50,000 IU/day.•No cases of hypercalcemia observed using these doses of vitamin D for up to 7 years.•The…”
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Vitamin D, cod liver oil, sunshine, and phototherapy: Safe, effective and forgotten tools for treating and curing tuberculosis infections — A comprehensive review by McCullough, Patrick J., Lehrer, Douglas S.

“…•TB is a major public health problem, affecting one third of the world’s population.•Vitamin D deficiency is common in patients infected with TB throughout the…”
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Psychiatric Comorbidities and Schizophrenia by Buckley, Peter F., Miller, Brian J., Lehrer, Douglas S., Castle, David J.

“…Psychiatric comorbidities are common among patients with schizophrenia. Substance abuse comorbidity predominates. Anxiety and depressive symptoms are also very…”
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Normal 24-hour urine calcium concentrations after long-term daily oral intake of vitamin D in doses ranging from 5000 to 50,000 international units in 14 adult hospitalized psychiatric patients by Repas, Steven J., Schmeusser, Benjamin N., McCullough, William P., Lehrer, Douglas S., Travers, Jeffrey B., McCullough, Patrick J.

“…Many controversies exist regarding vitamin D3 supplementation. These include not only diseases that are responsive to vitamin D supplementation, but also the…”
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Comparing Global Assessment of Functioning (GAF) and World Health Organization Disability Assessment Schedule (WHODAS) 2.0 in schizophrenia by Gspandl, Scott, Peirson, Ryan P., Nahhas, Ramzi W., Skale, Tracey Goodman, Lehrer, Douglas S.

“…WHODAS-2.0 is a suggested replacement to the GAF in DSM-5. This study's purpose was to assess their comparative correlation in adults with schizophrenia…”
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Four-modality imaging of unmedicated subjects with schizophrenia: 18F-fluorodeoxyglucose and 18F-fallypride PET, diffusion tensor imaging, and MRI by Buchsbaum, Monte S., Mitelman, Serge A., Christian, Bradley T., Merrill, Brian M., Buchsbaum, Bradley R., Mitelman, Danielle, Mukherjee, Jogeshwar, Lehrer, Douglas S.

“…•Combination of functional and structural imaging modalities provides better prediction of diagnosis of schizophrenia than either of the two…”
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D2/D3 dopamine receptor binding with [F-18]fallypride correlates of executive function in medication-naïve patients with schizophrenia by Vyas, Nora S, Buchsbaum, Monte S, Lehrer, Douglas S, Merrill, Brian M, DeCastro, Alex, Doninger, Nicholas A, Christian, Bradley T, Mukherjee, Jogeshwar

“…Abstract Converging evidence indicates that the prefrontal cortex is critically involved in executive control and that executive dysfunction is implicated in…”
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Reading abilities and dopamine D 2 /D 3 receptor availability: An inverted U-shaped association in subjects with schizophrenia by Mitelman, Serge A, Buchsbaum, Monte S, Vyas, Nora S, Christian, Bradley T, Merrill, Brian M, Buchsbaum, Bradley R, Mitelman, Alexis M, Mukherjee, Jogeshwar, Lehrer, Douglas S

“…Reading impairments are prominent trait-like features of cognitive deficits in schizophrenia, predictive of overall cognitive functioning and presumably linked…”
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Reading abilities and dopamine D2/D3 receptor availability: An inverted U-shaped association in subjects with schizophrenia by Mitelman, Serge A., Buchsbaum, Monte S., Vyas, Nora S., Christian, Bradley T., Merrill, Brian M., Buchsbaum, Bradley R., Mitelman, Alexis M., Mukherjee, Jogeshwar, Lehrer, Douglas S.

“…•Higher dopamine receptor density is associated with better reading ability.•Therefore, higher dopamine receptor density is cognitively…”
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Oral and Topical Vitamin D, Sunshine, and UVB Phototherapy Safely Control Psoriasis in Patients with Normal Pretreatment Serum 25-Hydroxyvitamin D Concentrations: A Literature Review and Discussion of Health Implications by McCullough, Patrick J, McCullough, William P, Lehrer, Douglas, Travers, Jeffrey B, Repas, Steven J

“…Vitamin D, sunshine and UVB phototherapy were first reported in the early 1900s to control psoriasis, cure rickets and cure tuberculosis (TB). Vitamin D also…”
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Anosognosia in schizophrenia: hidden in plain sight by Lehrer, Douglas S, Lorenz, Jennifer

“…Poor insight is a cardinal symptom of schizophrenia that, while not universally and uniformly expressed in all patients, is among the most common of its…”
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Relationship between white matter glucose metabolism and fractional anisotropy in healthy and schizophrenia subjects by Mitelman, Serge A., Buchsbaum, Monte S., Christian, Bradley T., Merrill, Brian M., Adineh, Mehdi, DeCastro, Alex, Buchsbaum, Bradley R., Lehrer, Douglas S.

“…Decreased fractional anisotropy and increased glucose utilization in the white matter have been reported in schizophrenia. These findings may be indicative of…”
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Positive association between cerebral grey matter metabolism and dopamine D 2 /D 3 receptor availability in healthy and schizophrenia subjects: An 18 F-fluorodeoxyglucose and 18 F-fallypride positron emission tomography study by Mitelman, Serge A, Buchsbaum, Monte S, Christian, Bradley T, Merrill, Brian M, Buchsbaum, Bradley R, Mukherjee, Jogeshwar, Lehrer, Douglas S

“…Overlapping decreases in extrastriatal dopamine D /D -receptor availability and glucose metabolism have been reported in subjects with schizophrenia. It…”
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Positive association between cerebral grey matter metabolism and dopamine D2/D3 receptor availability in healthy and schizophrenia subjects: An 18F-fluorodeoxyglucose and 18F-fallypride positron emission tomography study by Mitelman, Serge A., Buchsbaum, Monte S., Christian, Bradley T., Merrill, Brian M., Buchsbaum, Bradley R., Mukherjee, Jogeshwar, Lehrer, Douglas S.

“…Objectives: Overlapping decreases in extrastriatal dopamine D 2 /D 3 -receptor availability and glucose metabolism have been reported in subjects with…”
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Dopamine receptor density and white mater integrity: 18F-fallypride positron emission tomography and diffusion tensor imaging study in healthy and schizophrenia subjects by Mitelman, Serge A., Buchsbaum, Monte S., Christian, Bradley T., Merrill, Brian M., Buchsbaum, Bradley R., Mukherjee, Jogeshwar, Lehrer, Douglas S.

“…Dopaminergic dysfunction and changes in white matter integrity are among the most replicated findings in schizophrenia. A modulating role of dopamine in myelin…”
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The genomic psychiatry cohort: Partners in discovery by Pato, Michele T., Sobell, Janet L., Medeiros, Helena, Abbott, Colony, Sklar, Brooke M., Buckley, Peter F., Bromet, Evelyn J., Escamilla, Michael A., Fanous, Ayman H., Lehrer, Douglas S., Macciardi, Fabio, Malaspina, Dolores, McCarroll, Steve A., Marder, Stephen R., Moran, Jennifer, Morley, Christopher P., Nicolini, Humberto, Perkins, Diana O., Purcell, Shaun M., Rapaport, Mark H., Sklar, Pamela, Smoller, Jordan W., Knowles, James A., Pato, Carlos N.

“…The Genomic Psychiatry Cohort (GPC) is a longitudinal resource designed to provide the necessary population‐based sample for large‐scale genomic studies,…”
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Parental age effects on odor sensitivity in healthy subjects and schizophrenia patients by Malaspina, Dolores, Walsh-Messinger, Julie, Antonius, Daniel, Dracxler, Roberta, Rothman, Karen, Puthota, Jennifer, Gilman, Caitlin, Feuerstein, Jessica L., Keefe, David, Goetz, Deborah, Goetz, Raymond R., Buckley, Peter, Lehrer, Douglas S., Pato, Michele, Pato, Carlos

“…A schizophrenia phenotype for paternal and maternal age effects on illness risk could benefit etiological research. As odor sensitivity is associated with…”
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D2/D3 dopamine receptor binding with [F-18]fallypride in thalamus and cortex of patients with schizophrenia by Buchsbaum, Monte S., Christian, Bradley T., Lehrer, Douglas S., Narayanan, Tanjore K., Shi, Bingzhi, Mantil, Joseph, Kemether, Eileen, Oakes, Terrence R., Mukherjee, Jogeshwar

“…Abnormalities in the dopaminergic system are implicated in schizophrenia. [F-18]fallypride is a highly selective, high affinity PET ligand well suited for…”
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Paternal age effect: Replication in schizophrenia with intriguing dissociation between bipolar with and without psychosis by Lehrer, Douglas S., Pato, Michele T., Nahhas, Ramzi W., Miller, Brian R., Malaspina, Dolores, Buckley, Peter F., Sobell, Janet L., Walsh-Messinger, Julie, Pato, Carlos N.

“…Advanced paternal age (APA) is a risk factor for schizophrenia (Sz) and bipolar disorder (BP). Putative mechanisms include heritable genetic factors, de novo…”
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Measuring dopamine neuromodulation in the thalamus: Using [F-18]fallypride PET to study dopamine release during a spatial attention task by Christian, Bradley T., Lehrer, Douglas S., Shi, Bingzhi, Narayanan, Tanjore K., Strohmeyer, Pamela S., Buchsbaum, Monte S., Mantil, Joseph C.

“…We used the highly selective D2/D3 dopamine PET radioligand [F-18]fallypride to demonstrate that cognitive task induced dopamine release can be measured in the…”
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