Search Results - "Lehrbach, Nicolas J."

Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1 by Lehrbach, Nicolas J, Ruvkun, Gary

“…Proteasomes are essential for protein homeostasis in eukaryotes. To preserve cellular function, transcription of proteasome subunit genes is induced in…”
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Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression by Lehrbach, Nicolas J., Breen, Peter C., Ruvkun, Gary

“…The proteasome mediates selective protein degradation and is dynamically regulated in response to proteotoxic challenges. SKN-1A/Nrf1, an endoplasmic reticulum…”
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Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity by Lehrbach, Nicolas J, Ruvkun, Gary

“…Unfolded protein responses (UPRs) safeguard cellular function during proteotoxic stress and aging. In a previous paper (Lehrbach and Ruvkun, 2016) we showed…”
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piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans by Ashe, Alyson, Sapetschnig, Alexandra, Weick, Eva-Maria, Mitchell, Jacinth, Bagijn, Marloes P., Cording, Amy C., Doebley, Anna-Lisa, Goldstein, Leonard D., Lehrbach, Nicolas J., Le Pen, Jérémie, Pintacuda, Greta, Sakaguchi, Aisa, Sarkies, Peter, Ahmed, Shawn, Miska, Eric A.

“…Transgenerational effects have wide-ranging implications for human health, biological adaptation, and evolution; however, their mechanisms and biology remain…”
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Tertiary siRNAs mediate paramutation in C. elegans by Sapetschnig, Alexandra, Sarkies, Peter, Lehrbach, Nicolas J, Miska, Eric A

“…In the nematode Caenorhabditis elegans, different small RNA-dependent gene silencing mechanisms act in the germline to initiate transgenerational gene…”
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LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans by Lightfoot, Helen L, Murfitt, Kenneth J, Miska, Eric A, Armisen, Javier, Bugaut, Anthony, Balasubramanian, Shankar, Lehrbach, Nicolas J

“…Developmental expression of the microRNA let-7 is tightly regulated in many animals, and turnover has been linked to LIN-28 and uridylation in mammals. This…”
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Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility by Charlesworth, Amanda G, Seroussi, Uri, Lehrbach, Nicolas J, Renaud, Mathias S, Sundby, Adam E, Molnar, Ruxandra I, Lao, Robert X, Willis, Alexandra R, Woock, Jenna R, Aber, Matthew J, Diao, Annette J, Reinke, Aaron W, Ruvkun, Gary, Claycomb, Julie M

“…Abstract The Caenorhabditis elegans genome encodes nineteen functional Argonaute proteins that use 22G-RNAs, 26G-RNAs, miRNAs or piRNAs to regulate target…”
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Piwi and piRNAs Act Upstream of an Endogenous siRNA Pathway to Suppress Tc3 Transposon Mobility in the Caenorhabditis elegans Germline by Das, Partha P., Bagijn, Marloes P., Goldstein, Leonard D., Woolford, Julie R., Lehrbach, Nicolas J., Sapetschnig, Alexandra, Buhecha, Heeran R., Gilchrist, Michael J., Howe, Kevin L., Stark, Rory, Matthews, Nik, Berezikov, Eugene, Ketting, René F., Tavaré, Simon, Miska, Eric A.

“…The Piwi proteins of the Argonaute superfamily are required for normal germline development in Drosophila, zebrafish, and mice and associate with 24–30…”
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A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and antiviral immunity by Ashe, Alyson, Bélicard, Tony, Le Pen, Jérémie, Sarkies, Peter, Frézal, Lise, Lehrbach, Nicolas J, Félix, Marie-Anne, Miska, Eric A

“…RNA interference defends against viral infection in plant and animal cells. The nematode Caenorhabditis elegans and its natural pathogen, the positive-strand…”
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Post-developmental microRNA expression is required for normal physiology, and regulates aging in parallel to insulin/IGF-1 signaling in C. elegans by Lehrbach, Nicolas J, Castro, Cecilia, Murfitt, Kenneth J, Abreu-Goodger, Cei, Griffin, Julian L, Miska, Eric A

“…Regulation of gene expression by microRNAs (miRNAs) is essential for normal development, but the roles of miRNAs in the physiology of adult animals are poorly…”
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A quantitative targeted proteomics approach to validate predicted microRNA targets in C. elegans by Aebersold, Ruedi, O Hengartner, Michael, Jovanovic, Marko, Reiter, Lukas, Picotti, Paola, Lange, Vinzenz, Bogan, Erica, A Hurschler, Benjamin, Blenkiron, Cherie, J Lehrbach, Nicolas, C Ding, Xavier, Weiss, Manuel, P Schrimpf, Sabine, A Miska, Eric, Großhans, Helge

“…MicroRNA targets predicted by a variety of computational tools can be validated using a quantitative targeted proteomics approach, using stable isotope…”
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Function, Targets, and Evolution of Caenorhabditis elegans piRNAs by Bagijn, Marloes P., Goldstein, Leonard D., Sapetschnig, Alexandra, Weick, Eva-Maria, Bouasker, Samir, Lehrbach, Nicolas J., Simard, Martin J., Miska, Eric A.

“…Piwi-interacting RNAs (piRNAs) are small RNAs required to maintain germline integrity and fertility, but their mechanism of action is poorly understood. Here…”
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Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans by Tillman, Erik J, Richardson, Claire E, Cattie, Douglas J, Reddy, Kirthi C, Lehrbach, Nicolas J, Droste, Rita, Ruvkun, Gary, Kim, Dennis H

“…Animals have evolved critical mechanisms to maintain cellular and organismal proteostasis during development, disease, and exposure to environmental stressors…”
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The conserved miR-51 microRNA family is redundantly required for embryonic development and pharynx attachment in Caenorhabditis elegans by Shaw, W Robert, Armisen, Javier, Lehrbach, Nicolas J, Miska, Eric A

“…microRNAs (miRNAs) are approximately 22-nucleotide small RNAs that act as endogenous regulators of gene expression by base-pairing with target mRNAs. Here we…”
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A LIN28-Dependent Structural Change in pre-let-7g Directly Inhibits Dicer Processing by Lightfoot, Helen L, Bugaut, Anthony, Armisen, Javier, Lehrbach, Nicolas J, Miska, Eric A, Balasubramanian, Shankar

“…Several recent studies have provided evidence that LIN28, a cytoplasmic RNA-binding protein, inhibits the biogenesis of members of the let-7 microRNA family at…”
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An antisteatosis response regulated by oleic acid through lipid droplet-mediated ERAD enhancement by Castillo-Quan, Jorge Iván, Steinbaugh, Michael J, Fernández-Cárdenas, Laura Paulette, Pohl, Nancy K, Wu, Ziyun, Zhu, Feimei, Moroz, Natalie, Teixeira, Veronica, Bland, Monet S, Lehrbach, Nicolas J, Moronetti, Lorenza, Teufl, Magdalena, Blackwell, T Keith

“…Although excessive lipid accumulation is a hallmark of obesity-related pathologies, some lipids are beneficial. Oleic acid (OA), the most abundant…”
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Next-Generation Sequencing for Identification of EMS-Induced Mutations in Caenorhabditis elegans by Lehrbach, Nicolas J, Ji, Fei, Sadreyev, Ruslan

“…Forward genetic analysis using chemical mutagenesis in model organisms is a powerful tool for investigation of molecular mechanisms in biological systems. In…”
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A study of Caenorhabditis elegans DAF-2 mutants by metabolomics and differential correlation networks by Castro, Cecilia, Krumsiek, Jan, Lehrbach, Nicolas J, Murfitt, Steven A, Miska, Eric A, Griffin, Julian L

“…daf-2 is one of the most studied mutants in C. elegans: it contains a deletion in the gene orthologue of the insulin/insulin-like growth factor (IGF) receptor…”
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Regulation of pre-miRNA processing by Lehrbach, Nicolas J, Miska, Eric A

“…microRNAs are endogenously expressed 21 nucleotide noncoding RNAs. microRNA-mediated regulation of the translation of specific mRNA is implicated in a range of…”
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Tertiary siRNAs Mediate Paramutation in C . elegans: e1005078 by Sapetschnig, Alexandra, Sarkies, Peter, Lehrbach, Nicolas J, Miska, Eric A

“…In the nematode Caenorhabditis elegans, different small RNA-dependent gene silencing mechanisms act in the germline to initiate transgenerational gene…”
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