Search Results - "Lehr, Thorsten"

First-in-human application of the novel hepatitis B and hepatitis D virus entry inhibitor myrcludex B by Blank, Antje, Markert, Christoph, Hohmann, Nicolas, Carls, Alexandra, Mikus, Gerd, Lehr, Thorsten, Alexandrov, Alexander, Haag, Mathias, Schwab, Matthias, Urban, Stephan, Haefeli, Walter E

“…Background & Aims Myrcludex B is a first-in-class compound, which blocks entry of hepatitis B and D virus into hepatocytes in vitro and in animal models. Based…”
Get full text

PBPK Models for CYP3A4 and P‐gp DDI Prediction: A Modeling Network of Rifampicin, Itraconazole, Clarithromycin, Midazolam, Alfentanil, and Digoxin by Hanke, Nina, Frechen, Sebastian, Moj, Daniel, Britz, Hannah, Eissing, Thomas, Wendl, Thomas, Lehr, Thorsten

“…According to current US Food and Drug Administration (FDA) and European Medicines Agency (EMA) guidance documents, physiologically based pharmacokinetic (PBPK)…”
Get full text

Physiologically Based Pharmacokinetic Models of Probenecid and Furosemide to Predict Transporter Mediated Drug-Drug Interactions by Britz, Hannah, Hanke, Nina, Taub, Mitchell E., Wang, Ting, Prasad, Bhagwat, Fernandez, Éric, Stopfer, Peter, Nock, Valerie, Lehr, Thorsten

“…Purpose To provide whole-body physiologically based pharmacokinetic (PBPK) models of the potent clinical organic anion transporter (OAT) inhibitor probenecid…”
Get full text

Data Digitizing: Accurate and Precise Data Extraction for Quantitative Systems Pharmacology and Physiologically‐Based Pharmacokinetic Modeling by Wojtyniak, Jan‐Georg, Britz, Hannah, Selzer, Dominik, Schwab, Matthias, Lehr, Thorsten

“…In quantitative systems pharmacology (QSP) and physiologically‐based pharmacokinetic (PBPK) modeling, data digitizing is a valuable tool to extract numerical…”
Get full text

Physiologically Based Pharmacokinetic Models for Prediction of Complex CYP2C8 and OATP1B1 (SLCO1B1) Drug–Drug–Gene Interactions: A Modeling Network of Gemfibrozil, Repaglinide, Pioglitazone, Rifampicin, Clarithromycin and Itraconazole by Türk, Denise, Hanke, Nina, Wolf, Sarah, Frechen, Sebastian, Eissing, Thomas, Wendl, Thomas, Schwab, Matthias, Lehr, Thorsten

“…Background Drug–drug interactions (DDIs) and drug–gene interactions (DGIs) pose a serious health risk that can be avoided by dose adaptation. These…”
Get full text

A Physiologically Based Pharmacokinetic Model of Voriconazole Integrating Time-Dependent Inhibition of CYP3A4, Genetic Polymorphisms of CYP2C19 and Predictions of Drug–Drug Interactions by Li, Xia, Frechen, Sebastian, Moj, Daniel, Lehr, Thorsten, Taubert, Max, Hsin, Chih-hsuan, Mikus, Gerd, Neuvonen, Pertti J., Olkkola, Klaus T., Saari, Teijo I., Fuhr, Uwe

“…Background Voriconazole, a first-line antifungal drug, exhibits nonlinear pharmacokinetics (PK), together with large interindividual variability but a narrow…”
Get full text

Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug-Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach by Fuhr, Laura Maria, Marok, Fatima Zahra, Hanke, Nina, Selzer, Dominik, Lehr, Thorsten

“…The anticonvulsant carbamazepine is frequently used in the long-term therapy of epilepsy and is a known substrate and inducer of cytochrome P450 (CYP) 3A4 and…”
Get full text

A Physiologically-Based Pharmacokinetic Model of Trimethoprim for MATE1, OCT1, OCT2, and CYP2C8 Drug–Drug–Gene Interaction Predictions by Türk, Denise, Hanke, Nina, Lehr, Thorsten

“…Trimethoprim is a frequently-prescribed antibiotic and therefore likely to be co-administered with other medications, but it is also a potent inhibitor of…”
Get full text

Vacuolar-ATPase Inhibition Blocks Iron Metabolism to Mediate Therapeutic Effects in Breast Cancer by Schneider, Lina S, von Schwarzenberg, Karin, Lehr, Thorsten, Ulrich, Melanie, Kubisch-Dohmen, Rebekka, Liebl, Johanna, Trauner, Dirk, Menche, Dirk, Vollmar, Angelika M

“…Generalized strategies to improve breast cancer treatment remain of interest to develop. In this study, we offer preclinical evidence of an important metabolic…”
Get full text

Physiologically‐based pharmacokinetic modeling of dextromethorphan to investigate interindividual variability within CYP2D6 activity score groups by Rüdesheim, Simeon, Selzer, Dominik, Fuhr, Uwe, Schwab, Matthias, Lehr, Thorsten

“…This study provides a whole‐body physiologically‐based pharmacokinetic (PBPK) model of dextromethorphan and its metabolites dextrorphan and dextrorphan…”
Get full text

Population pharmacokinetic modeling of multiple-dose intravenous fosfomycin in critically ill patients during continuous venovenous hemodialysis by Hüppe, Tobias, Götz, Katharina M., Meiser, Andreas, de Faria Fernandes, Andrea, Maurer, Felix, Groesdonk, Heinrich V., Volk, Thomas, Lehr, Thorsten, Kreuer, Sascha

“…The aim of this study was to investigate the pharmacokinetics of multiple-dose intravenous (i.v.) fosfomycin in critically ill patients during continuous…”
Get full text

Open Systems Pharmacology Community—An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences by Lippert, Jörg, Burghaus, Rolf, Edginton, Andrea, Frechen, Sebastian, Karlsson, Mats, Kovar, Andreas, Lehr, Thorsten, Milligan, Peter, Nock, Valerie, Ramusovic, Sergej, Riggs, Matthew, Schaller, Stephan, Schlender, Jan, Schmidt, Stephan, Sevestre, Michaël, Sjögren, Erik, Solodenko, Juri, Staab, Alexander, Teutonico, Donato

“…Open Systems Pharmacology is a community that develops, qualifies, and shares professional open source software tools and models in a collaborative…”
Get full text

Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates by Kovar, Lukas, Schräpel, Christina, Selzer, Dominik, Kohl, Yvonne, Bals, Robert, Schwab, Matthias, Lehr, Thorsten

“…Buprenorphine plays a crucial role in the therapeutic management of pain in adults, adolescents and pediatric subpopulations. However, only few pharmacokinetic…”
Get full text

A comparison of dabigatran etexilate with warfarin in patients with mechanical heart valves: The Randomized, phase II study to Evaluate the sAfety and pharmacokinetics of oraL dabIGatran etexilate in patients after heart valve replacemeNt (RE-ALIGN) by Van de Werf, Frans, MD, Brueckmann, Martina, MD, Connolly, Stuart J., MD, Friedman, Jeffrey, MD, Granger, Christopher B., MD, Härtter, Sebastian, PhD, Harper, Ruth, MD, Kappetein, Arie Pieter, MD, Lehr, Thorsten, PhD, Mack, Michael J., MD, Noack, Herbert, PhD, Eikelboom, John W., MD

“…Background Vitamin K antagonists are the only oral anticoagulants approved for long-term treatment of patients with a cardiac valve replacement. Objective This…”
Get full text

A Physiologically Based Pharmacokinetic and Pharmacodynamic Model of the CYP3A4 Substrate Felodipine for Drug–Drug Interaction Modeling by Fuhr, Laura Maria, Marok, Fatima Zahra, Mees, Maximilian, Mahfoud, Felix, Selzer, Dominik, Lehr, Thorsten

“…The antihypertensive felodipine is a calcium channel blocker of the dihydropyridine type, and its pharmacodynamic effect directly correlates with its plasma…”
Get full text

Target-Mediated Drug Disposition Pharmacokinetic–Pharmacodynamic Model of Bosentan and Endothelin-1 by Volz, Anke-Katrin, Krause, Andreas, Haefeli, Walter Emil, Dingemanse, Jasper, Lehr, Thorsten

“…Background and Objectives Bosentan is a competitive antagonist on endothelin receptor A and B (ET A and ET B ), displacing the endogenous binding partner…”
Get full text

In Vitro-In Silico Modeling of Caffeine and Diclofenac Permeation in Static and Fluidic Systems with a 16HBE Lung Cell Barrier by Kovar, Lukas, Wien, Lena, Selzer, Dominik, Kohl, Yvonne, Bals, Robert, Lehr, Thorsten

“…Static in vitro permeation experiments are commonly used to gain insights into the permeation properties of drug substances but exhibit limitations due to…”
Get full text

A physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model of the histone deacetylase (HDAC) inhibitor vorinostat for pediatric and adult patients and its application for dose specification by Moj, Daniel, Britz, Hannah, Burhenne, Jürgen, Stewart, Clinton F., Egerer, Gerlinde, Haefeli, Walter E., Lehr, Thorsten

“…Purpose This study aimed at recommending pediatric dosages of the histone deacetylase (HDAC) inhibitor vorinostat and potentially more effective adult dosing…”
Get full text

A Physiologically‐Based Quantitative Systems Pharmacology Model of the Incretin Hormones GLP‐1 and GIP and the DPP4 Inhibitor Sitagliptin by Balazki, Pavel, Schaller, Stephan, Eissing, Thomas, Lehr, Thorsten

“…Incretin hormones glucagon‐like peptide‐1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP) play a major role in regulation of postprandial…”
Get full text

Translational PBPK Modeling of the Protein Therapeutic and CD95L Inhibitor Asunercept to Develop Dose Recommendations for Its First Use in Pediatric Glioblastoma Patients by Hanke, Nina, Kunz, Claudia, Thiemann, Meinolf, Fricke, Harald, Lehr, Thorsten

“…The protein therapeutic and CD95L inhibitor asunercept is currently under clinical investigation for the treatment of glioblastoma and myelodysplastic…”
Get full text