Search Results - "Lehr, H."

Long-term outcome prediction by clinicopathological risk classification algorithms in node-negative breast cancer—comparison between Adjuvant!, St Gallen, and a novel risk algorithm used in the prospective randomized Node-Negative-Breast Cancer-3 (NNBC-3) trial by Schmidt, M., Victor, A., Bratzel, D., Boehm, D., Cotarelo, C., Lebrecht, A., Siggelkow, W., Hengstler, J. G., Elsäßer, A., Gehrmann, M., Lehr, H. -A., Koelbl, H., von Minckwitz, G., Harbeck, N., Thomssen, C.

“…Background: Defining risk categories in breast cancer is of considerable clinical significance. We have developed a novel risk classification algorithm and…”
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In vivo imaging of colitis and colon cancer development in mice using high resolution chromoendoscopy by Becker, C, Fantini, M C, Wirtz, S, Nikolaev, A, Kiesslich, R, Lehr, H A, Galle, P R, Neurath, M F

“…Background: Mouse models of colitis and cancer are indispensable for our understanding of the pathogenesis of these diseases. In the past, mice had to be…”
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Acid mine drainage, rock drainage, and acid sulfate soils: causes, assessment, prediction, prevention, and remediation. by Jacobs, James A, Lehr, Jay H, Testa, Stephen M

“…Featuring contributions from leading experts in science and engineering, this book explores the complex biogeochemistry of acid mine drainage, rock drainage,…”
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MFG-E8 lactadherin regulates cyclins D1 D3 expression and enhances the tumorigenic potential of mammary epithelial cells by Carrascosa, C, Obula, R G, Missiaglia, E, Lehr, H-A, Delorenzi, M, Frattini, M, Rüegg, C, Mariotti, A

“…Milk fat globule-EGF factor 8 (MFG-E8) is a glycoprotein highly expressed in breast cancer that contributes to tumor progression through largely undefined…”
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Precision Livestock Farming: An international review of scientific and commercial aspects[dagger] by Banhazi, T M, Lehr, H, Black, J L, Crabtree, H, Schofield, P, Tscharke, M, Berckmans, D

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Transforming growth factor β induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis by Fantini, M C, Becker, C, Tubbe, I, Nikolaev, A, Lehr, H A, Galle, P, Neurath, M F

“…Background and aims: The imbalance between effector and regulatory T cells plays a central role in the pathogenesis of inflammatory bowel diseases. In addition…”
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Real-Time Detection of Nucleic Acid Interactions by Total Internal Reflection Fluorescence by Lehr, H.-P, Reimann, M, Brandenburg, A, Sulz, G, Klapproth, H

“…This paper describes the development of an optical readout system for the real-time analysis of fluorescent-labeled DNA microarrays is described. The system is…”
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Thermal Damage of the Inner Vein Wall During Endovenous Laser Treatment: Key Role of Energy Absorption by Intravascular Blood by Proebstle, T. M., Sandhofer, M., Kargl, A., Gül, D., Rother, W., Knop, J., Lehr, H. A.

“…background. Despite the clinical efficacy of endovenous laser treatment (EVLT), its mode of action is incompletely understood. objective. To evaluate the role…”
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A role for T-bet-mediated tumour immune surveillance in anti-IL-17A treatment of lung cancer by Reppert, S., Boross, I., Koslowski, M., Türeci, Ö., Koch, S., Lehr, H.A., Finotto, S.

“…Lung cancer is the leading cause of cancer deaths worldwide. The cytokine interleukin-17A supports tumour vascularization and growth, however, its role in lung…”
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Infrequent early recanalization of greater saphenous vein after endovenous laser treatment by Proebstle, T.M, Gül, D, Lehr, H.A, Kargl, A, Knop, J

“…The frequency of recanalization of the greater saphenous vein (GSV) after endovenous laser treatment (ELT) is unclear. This study was undertaken to establish…”
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Dexamethasone suppresses eNOS and CAT-1 and induces oxidative stress in mouse resistance arterioles by Schäfer, S C, Wallerath, T, Closs, E I, Schmidt, C, Schwarz, P M, Förstermann, U, Lehr, H-A

“…Long-term treatment with glucocorticoids is associated with mild to moderate hypertension. We reported previously that downregulation of endothelial NO…”
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IL-1β-Converting Enzyme (Caspase-1) in Intestinal Inflammation by Seigmund, Britta, Lehr, Hans-Anton, Fantuzzi, Giamila, Dinarello, Charles A.

“…IL-1β-converting enzyme (ICE; caspase-1) is the intracellular protease that cleaves the precursors of LI-1β and IL-18 into active cytokines. In the present…”
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Dendritic cell-based vaccination combined with gemcitabine increases survival in a murine pancreatic carcinoma model by Bauer, C, Bauernfeind, F, Sterzik, A, Orban, M, Schnurr, M, Lehr, H A, Endres, S, Eigler, A, Dauer, M

“…Background: Tumour-specific cytotoxic T lymphocytes (CTLs) can be activated in vivo by vaccination with dendritic cells (DCs). However, clinical responses to…”
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Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo by Neurath, M.F, Atreya, R, Mudter, J, Finotto, S, Müllberg, J, Jostock, T, Wirtz, S, Schütz, M, Bartsch, B, Holtmann, M, Becker, C, Strand, D, Czaja, J, Schlaak, J. F, Lehr, H.A, Autschbach, F, Schürmann, G, Nishimoto, N, Yoshizaki, K, Ito, H, Kishimoto, T, Galle, P.R, Rose-John, S

“…The pro-inflammatory cytokine interleukin (IL)-6 (refs. 1-5) can bind to cells lacking the IL-6 receptor (IL-6R) when it forms a complex with the soluble IL-6R…”
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Endovenous treatment of the greater saphenous vein with a 940-nm diode laser: Thrombotic occlusion after endoluminal thermal damage by laser-generated steam bubbles by Proebstle, T.M., Lehr, H.A., Kargl, A., Espinola-Klein, C., Rother, W., Bethge, S., Knop, J.

“…Purpose: Despite a rapid spread of the technique, very little is known about the laser-tissue interaction in endovenous laser treatment (EVLT). We evaluated…”
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Mesenteric fat—control site for bacterial translocation in colitis? by Batra, A, Heimesaat, M M, Bereswill, S, Fischer, A, Glauben, R, Kunkel, D, Scheffold, A, Erben, U, Kühl, A, Loddenkemper, C, Lehr, H-A, Schumann, M, Schulzke, J-D, Zeitz, M, Siegmund, B

“…In Crohn's disease bacteria could be detected in the adjacent mesenteric fat characterized by hypertrophy of unknown function. This study aimed to define…”
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Leptin receptor expression on T lymphocytes modulates chronic intestinal inflammation in mice by Siegmund, B, Sennello, J A, Jones-Carson, J, Gamboni-Robertson, F, Lehr, H A, Batra, A, Fedke, I, Zeitz, M, Fantuzzi, G

“…Background: Leptin regulates appetite through the long isoform of its receptor in the hypothalamus. Although leptin regulates immune responses, it is still…”
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Down-Regulation of the Expression of Endothelial NO Synthase Is Likely to Contribute to Glucocorticoid-Mediated Hypertension by Wallerath, Thomas, Witte, Klaus, Schäfer, Stephan C., Schwarz, Petra M., Prellwitz, Winfried, Wohlfart, Paulus, Kleinert, Hartmut, Lehr, Hans-Anton, Lemmer, Björn, Förstermann, Ulrich

“…Hypertension is a side effect of systemically administered glucocorticoids, but the underlying molecular mechanism remains poorly understood. Ingestion of…”
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Enhanced dendritic cell maturation by TNF-alpha or cytidine-phosphate-guanosine DNA drives T cell activation in vitro and therapeutic anti-tumor immune responses in vivo by Brunner, C, Seiderer, J, Schlamp, A, Bidlingmaier, M, Eigler, A, Haimerl, W, Lehr, H A, Krieg, A M, Hartmann, G, Endres, S

“…Dendritic cells (DC) manipulated ex vivo can induce tumor immunity in experimental murine tumor models. To improve DC-based tumor vaccination, we studied…”
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Severe hepatic injury in interleukin 18 (IL-18) transgenic mice: a key role for IL-18 in regulating hepatocyte apoptosis in vivo by Finotto, S, Siebler, J, Hausding, M, Schipp, M, Wirtz, S, Klein, S, Protschka, M, Doganci, A, Lehr, H A, Trautwein, C, Khosravi-Fahr, R, Strand, D, Lohse, A, Galle, P R, Blessing, M, Neurath, M F

“…Background: Interleukin 18 (IL-18) is a cytokine with pleiotropic activity that augments T helper 1 responses and cytotoxic activity of natural killer cells…”
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