Search Results - "Lehr, C.M."

Preparation and characterization of cationic PLGA nanospheres as DNA carriers by Ravi Kumar, M.N.V., Bakowsky, U., Lehr, C.M.

“…Nanoparticles formulated from biodegradable polymers such as poly(lactic acid) (PLA) and poly(lactide-co-glycolide) (PLGA) are being extensively investigated…”
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Finite dose skin mass balance including the lateral part: Comparison between experiment, pharmacokinetic modeling and diffusion models by Selzer, D., Hahn, T., Naegel, A., Heisig, M., Kostka, K.H., Lehr, C.M., Neumann, D., Schaefer, U.F., Wittum, G.

“…This work investigates in vitro finite dose skin absorption of the model compounds flufenamic acid and caffeine experimentally and mathematically. The mass…”
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1224 POSTER Docetaxel Delivery Mediated by Nanoparticles of Novel Hydrophobic Starch by Dandekar, P, Jain, R, Stauner, T, Loretz, B, Koch, M, Wenz, G, Lehr, C.M

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1223 POSTER Enhanced Cellular Delivery of Idarubicin by Surface Modification of Propyl Starch Nanoparticles Employing Pteroic Acid Conjugated Polyvinyl Alcohol by Ratnesh, J, Dandekar, P, Loretz, B, Melero, A, Stauner, T, Wenz, G, Koch, M, Lehr, C.M

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Process optimization and biocompatibility of cell carriers suitable for automated magnetic manipulation by Krejci, I., Piana, C., Howitz, S., Wegener, T., Fiedler, S., Zwanzig, M., Schmitt, D., Daum, N., Meier, K., Lehr, C.M., Batista, U., Zemljic, S., Messerschmidt, J., Franzke, J., Wirth, M., Gabor, F.

“…There is increasing demand for automated cell reprogramming in the fields of cell biology, biotechnology and the biomedical sciences. Microfluidic-based…”
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Nanoparticles made from novel starch derivatives for transdermal drug delivery by Santander-Ortega, M.J., Stauner, T., Loretz, B., Ortega-Vinuesa, J.L., Bastos-González, D., Wenz, G., Schaefer, U.F., Lehr, C.M.

“…The goal of this paper was aimed to the formulation of nanoparticles by using two different propyl-starch derivatives – referred to as PS-1 and PS-1.45 – with…”
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Nanocarriers for optimizing the balance between interfollicular permeation and follicular uptake of topically applied clobetasol to minimize adverse effects by Mathes, C., Melero, A., Conrad, P., Vogt, T., Rigo, L., Selzer, D., Prado, W.A., De Rossi, C., Garrigues, T.M., Hansen, S., Guterres, S.S., Pohlmann, A.R., Beck, R.C.R., Lehr, C.-M., Schaefer, U.F.

“…The treatment of various hair disorders has become a central focus of good dermatologic patient care as it affects men and women all over the world. For many…”
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The effect of polymer size and charge of molecules on permeation through synovial membrane and accumulation in hyaline articular cartilage by Sterner, B., Harms, M., Wöll, S., Weigandt, M., Windbergs, M., Lehr, C.M.

“…[Display omitted] The treatment of joint related diseases often involves direct intra-articular injections. For rational development of novel delivery systems…”
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Telomerase as an emerging target to fight cancer — Opportunities and challenges for nanomedicine by Philippi, C., Loretz, B., Schaefer, U.F., Lehr, C.M.

“…Telomerase as an enzyme is responsible for the renewal of the chromosomal ends, the so-called telomeres. By preventing them from shortening with each cell…”
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Crystal suspensions of poorly soluble peptides for intra-articular application: A novel approach for biorelevant assessment of their in vitro release by Sterner, B., Harms, M., Weigandt, M., Windbergs, M., Lehr, C.M.

“…Crystal suspensions of 3 poorly soluble peptides (MSC1, 2 and 3), intended for intra-articular administration were prepared and in vitro release was tested by…”
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Nortriptyline hydrochloride skin absorption: Development of a transdermal patch by Melero, Ana, Garrigues, T.M., Almudever, P., Villodre, A. Martı´n, Lehr, C.M., Schäfer, U.

“…The influence of propylen glycol (PG), ethanol, and oleic acid (OA) on nortriptyline hydrochloride (NTH) penetration through human epidermis was studied in…”
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Dexamethasone-loaded nanoparticle-coated microparticles: Correlation between in vitro drug release and drug transport across Caco-2 cell monolayers by Beck, R.C.R., Pohlmann, A.R., Hoffmeister, C., Gallas, M.R., Collnot, E., Schaefer, U.F., Guterres, S.S., Lehr, C.M.

“…This work reports the preparation of dexamethasone in nanoparticle-coated microparticles and the study of the influence of such microencapsulation on drug…”
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Self-Assembly of β-Lactoglobulin and Acacia Gum in Aqueous Solvent:  Structure and Phase-Ordering Kinetics by Sanchez, C, Mekhloufi, G, Schmitt, C, Renard, D, Robert, P, Lehr, C.-M, Lamprecht, A, Hardy, J

“…Complex coacervation in β-lactoglobulin (BLG)/acacia gum (AG) dispersions has been studied at pH 4.2 using time-resolved confocal scanning laser microscopy…”
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Nortriptyline for smoking cessation: Release and human skin diffusion from patches by Melero, A., Garrigues, T.M., Alós, M., Kostka, K.H., Lehr, C.M., Schaefer, U.F.

“…The objective of this work was to develop a simple and inexpensive transdermal formulation containing Nortriptyline Hydrochloride (NTH) for smoking cessation…”
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Comparative Evaluation of Corneal Epithelial Cell Cultures for Assessing Ocular Permeability by Becker, U, Ehrhardt, C, Schneider, M, Muys, L, Gross, D, Eschmann, K, Schaefer, U.F, Lehr, C.M

“…The purpose of this study was to evaluate the potential value of different epithelial cell culture systems as in vitro models for studying corneal…”
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GALENOS Euro-PhD in Advanced Drug Delivery: an innovative European Postgraduate Certificate for young pharmaceutical scientists, funded by the EU Marie Curie EST programme by Lehr, C.M.

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Study of β-lactoglobulin/acacia gum complex coacervation by diffusing-wave spectroscopy and confocal scanning laser microscopy by Schmitt, Christophe, Sanchez, Christian, Lamprecht, Alf, Renard, Denis, Lehr, Claus-Michael, de Kruif, Cees G, Hardy, Joël

“…Complex coacervation has been investigated on mixtures of β-lactoglobulin (β-lg) and acacia gum (AG) at pH 4.2 where these two macromolecules interact…”
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Cell culture models and nanobiotechnology—contemporary topics in advanced drug delivery research by Lehr, C.M.

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Lectin-mediated Drug Delivery: Discrimination Between Cytoadhesion and Cytoinvasion and Evidence for Lysosomal Accumulation of Wheat Germ Agglutinin in the Caco-2 Model by Wirth, M., Kneuer, C., Lehr, C.M., Gabor, F.

“…Lectin-mediated drug delivery may become a promising strategy to improve the efficacy of poorly permeable drugs by utilising active high-capacity transport…”
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P 4 The xenopus lung as a model for alveolar drug transport: Assessment of bioelectrical parameters by Bartels, M., Lehr, C.M.

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