Search Results - "Lehner, Paul J"

Genome surveillance by HUSH-mediated silencing of intronless mobile elements by Seczynska, Marta, Bloor, Stuart, Cuesta, Sergio Martinez, Lehner, Paul J.

“…All life forms defend their genome against DNA invasion. Eukaryotic cells recognize incoming DNA and limit its transcription through repressive chromatin…”
Get full text

Neural stem cells traffic functional mitochondria via extracellular vesicles by Peruzzotti-Jametti, Luca, Bernstock, Joshua D, Willis, Cory M, Manferrari, Giulia, Rogall, Rebecca, Fernandez-Vizarra, Erika, Williamson, James C, Braga, Alice, van den Bosch, Aletta, Leonardi, Tommaso, Krzak, Grzegorz, Kittel, Ágnes, Benincá, Cristiane, Vicario, Nunzio, Tan, Sisareuth, Bastos, Carlos, Bicci, Iacopo, Iraci, Nunzio, Smith, Jayden A, Peacock, Ben, Muller, Karin H, Lehner, Paul J, Buzas, Edit Iren, Faria, Nuno, Zeviani, Massimo, Frezza, Christian, Brisson, Alain, Matheson, Nicholas J, Viscomi, Carlo, Pluchino, Stefano

“…Neural stem cell (NSC) transplantation induces recovery in animal models of central nervous system (CNS) diseases. Although the replacement of lost endogenous…”
Get full text

No evidence for basigin/CD147 as a direct SARS-CoV-2 spike binding receptor by Shilts, Jarrod, Crozier, Thomas W. M., Greenwood, Edward J. D., Lehner, Paul J., Wright, Gavin J.

“…The spike protein of SARS-CoV-2 is known to enable viral invasion into human cells through direct binding to host receptors including ACE2. An alternate entry…”
Get full text

Quantitative temporal viromics: an approach to investigate host-pathogen interaction by Weekes, Michael P, Tomasec, Peter, Huttlin, Edward L, Fielding, Ceri A, Nusinow, David, Stanton, Richard J, Wang, Eddie C Y, Aicheler, Rebecca, Murrell, Isa, Wilkinson, Gavin W G, Lehner, Paul J, Gygi, Steven P

“…A systematic quantitative analysis of temporal changes in host and viral proteins throughout the course of a productive infection could provide dynamic…”
Get full text

NOTCH1 mediates a switch between two distinct secretomes during senescence by Hoare, Matthew, Ito, Yoko, Kang, Tae-Won, Weekes, Michael P., Matheson, Nicholas J., Patten, Daniel A., Shetty, Shishir, Parry, Aled J., Menon, Suraj, Salama, Rafik, Antrobus, Robin, Tomimatsu, Kosuke, Howat, William, Lehner, Paul J., Zender, Lars, Narita, Masashi

“…Senescence, a persistent form of cell-cycle arrest, is often associated with a diverse secretome, which provides complex functionality for senescent cells…”
Get full text

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer by Burr, Marian L., Sparbier, Christina E., Chan, Kah Lok, Chan, Yih-Chih, Kersbergen, Ariena, Lam, Enid Y.N., Azidis-Yates, Elizabeth, Vassiliadis, Dane, Bell, Charles C., Gilan, Omer, Jackson, Susan, Tan, Lavinia, Wong, Stephen Q., Hollizeck, Sebastian, Michalak, Ewa M., Siddle, Hannah V., McCabe, Michael T., Prinjha, Rab K., Guerra, Glen R., Solomon, Benjamin J., Sandhu, Shahneen, Dawson, Sarah-Jane, Beavis, Paul A., Tothill, Richard W., Cullinane, Carleen, Lehner, Paul J., Sutherland, Kate D., Dawson, Mark A.

“…Loss of MHC class I (MHC-I) antigen presentation in cancer cells can elicit immunotherapy resistance. A genome-wide CRISPR/Cas9 screen identified an…”
Get full text

Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells by Tchasovnikarova, Iva A., Timms, Richard T., Matheson, Nicholas J., Wals, Kim, Antrobus, Robin, Göttgens, Berthold, Dougan, Gordon, Dawson, Mark A., Lehner, Paul J.

“…Forward genetic screens in Drosophila melanogaster for modifiers of position-effect variegation have revealed the basis of much of our understanding of…”
Get full text

Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef by Matheson, Nicholas J., Sumner, Jonathan, Wals, Kim, Rapiteanu, Radu, Weekes, Michael P., Vigan, Raphael, Weinelt, Julia, Schindler, Michael, Antrobus, Robin, Costa, Ana S.H., Frezza, Christian, Clish, Clary B., Neil, Stuart J.D., Lehner, Paul J.

“…Critical cell surface immunoreceptors downregulated during HIV infection have previously been identified using non-systematic, candidate approaches. To gain a…”
Get full text

ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex by Timms, Richard T., Tchasovnikarova, Iva A., Antrobus, Robin, Dougan, Gordon, Lehner, Paul J.

“…The histone methyltransferase SETDB1 plays a central role in repressive chromatin processes, but the functional requirement for its binding partner ATF7IP has…”
Get full text

Hyperactivation of HUSH complex function by Charcot–Marie–Tooth disease mutation in MORC2 by Tchasovnikarova, Iva A, Timms, Richard T, Douse, Christopher H, Roberts, Rhys C, Dougan, Gordon, Kingston, Robert E, Modis, Yorgo, Lehner, Paul J

“…Paul Lehner and colleagues identify an essential role for MORC2 in HUSH complex–mediated epigenetic silencing. They show that loss of MORC2 causes chromatin…”
Get full text

Ubiquitin-mediated regulation of sterol homeostasis by van den Boomen, Dick J.H., Volkmar, Norbert, Lehner, Paul J.

“…Cholesterol is an essential component of mammalian membranes, and its homeostasis is strictly regulated, with imbalances causing atherosclerosis, Niemann Pick…”
Get full text

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions by Burr, Stephen P., Costa, Ana S.H., Grice, Guinevere L., Timms, Richard T., Lobb, Ian T., Freisinger, Peter, Dodd, Roger B., Dougan, Gordon, Lehner, Paul J., Frezza, Christian, Nathan, James A.

“…Hypoxia-inducible transcription factors (HIFs) control adaptation to low oxygen environments by activating genes involved in metabolism, angiogenesis, and…”
Get full text

Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms by Douse, Christopher H., Bloor, Stuart, Liu, Yangci, Shamin, Maria, Tchasovnikarova, Iva A., Timms, Richard T., Lehner, Paul J., Modis, Yorgo

“…Missense mutations in MORC2 cause neuropathies including spinal muscular atrophy and Charcot–Marie–Tooth disease. We recently identified MORC2 as an effector…”
Get full text

Promiscuous Targeting of Cellular Proteins by Vpr Drives Systems-Level Proteomic Remodeling in HIV-1 Infection by Greenwood, Edward J.D., Williamson, James C., Sienkiewicz, Agata, Naamati, Adi, Matheson, Nicholas J., Lehner, Paul J.

“…HIV-1 encodes four “accessory proteins” (Vif, Vpr, Vpu, and Nef), dispensable for viral replication in vitro but essential for viral pathogenesis in vivo. Well…”
Get full text

TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control by Douse, Christopher H., Tchasovnikarova, Iva A., Timms, Richard T., Protasio, Anna V., Seczynska, Marta, Prigozhin, Daniil M., Albecka, Anna, Wagstaff, Jane, Williamson, James C., Freund, Stefan M. V., Lehner, Paul J., Modis, Yorgo

“…The HUSH complex represses retroviruses, transposons and genes to maintain the integrity of vertebrate genomes. HUSH regulates deposition of the epigenetic…”
Get full text

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export by van den Boomen, Dick J. H., Sienkiewicz, Agata, Berlin, Ilana, Jongsma, Marlieke L. M., van Elsland, Daphne M., Luzio, J. Paul, Neefjes, Jacques J. C., Lehner, Paul J.

“…Cholesterol import in mammalian cells is mediated by the LDL receptor pathway. Here, we perform a genome-wide CRISPR screen using an endogenous cholesterol…”
Get full text

Integrative functional genomics decodes herpes simplex virus 1 by Whisnant, Adam W., Jürges, Christopher S., Hennig, Thomas, Wyler, Emanuel, Prusty, Bhupesh, Rutkowski, Andrzej J., L’hernault, Anne, Djakovic, Lara, Göbel, Margarete, Döring, Kristina, Menegatti, Jennifer, Antrobus, Robin, Matheson, Nicholas J., Künzig, Florian W. H., Mastrobuoni, Guido, Bielow, Chris, Kempa, Stefan, Liang, Chunguang, Dandekar, Thomas, Zimmer, Ralf, Landthaler, Markus, Grässer, Friedrich, Lehner, Paul J., Friedel, Caroline C., Erhard, Florian, Dölken, Lars

“…The predicted 80 open reading frames (ORFs) of herpes simplex virus 1 (HSV-1) have been intensively studied for decades. Here, we unravel the complete viral…”
Get full text

The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1 by Menzies, Sam A, Volkmar, Norbert, van den Boomen, Dick Jh, Timms, Richard T, Dickson, Anna S, Nathan, James A, Lehner, Paul J

“…Mammalian HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the cholesterol biosynthetic pathway and the therapeutic target of statins, is…”
Get full text

Position-effect variegation revisited: HUSHing up heterochromatin in human cells by Timms, Richard T., Tchasovnikarova, Iva A., Lehner, Paul J.

“…Much of what we understand about heterochromatin formation in mammals has been extrapolated from forward genetic screens for modifiers of position‐effect…”
Get full text

UBE2L3 Polymorphism Amplifies NF-κB Activation and Promotes Plasma Cell Development, Linking Linear Ubiquitination to Multiple Autoimmune Diseases by Lewis, Myles J., Vyse, Simon, Shields, Adrian M., Boeltz, Sebastian, Gordon, Patrick A., Spector, Timothy D., Lehner, Paul J., Walczak, Henning, Vyse, Timothy J.

“…UBE2L3 is associated with increased susceptibility to numerous autoimmune diseases, but the underlying mechanism is unexplained. By using data from a…”
Get full text