Search Results - "Lehner, Martin D."

A combination of carbonates and Opuntia ficus-indica extract protects esophageal cells against simulated acidic and non-acidic reflux in vitro by Lehner, Martin D., Scheyhing, Ulrike, Elsässer, Jens

“…Buffering of stomach acid by antacids is a well-established symptomatic therapy for heartburn. In addition, preparations from prickly pear ( Opuntia…”
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EPs ® 7630 Stimulates Tissue Repair Mechanisms and Modifies Tight Junction Protein Expression in Human Airway Epithelial Cells by Fang, Lei, Zhou, Liang, Kulić, Žarko, Lehner, Martin D, Tamm, Michael, Roth, Michael

“…Airway epithelium repair after infection consists of wound repair, re-synthesis of the extracellular matrix (ECM), and tight junction proteins. In humans, EPs…”
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Anti-Neuroinflammatory Effects of Ginkgo biloba Extract EGb 761 in LPS-Activated BV2 Microglial Cells by Sun, Lu, Apweiler, Matthias, Tirkey, Ashwini, Klett, Dominik, Normann, Claus, Dietz, Gunnar P H, Lehner, Martin D, Fiebich, Bernd L

“…Inflammatory processes in the brain can exert important neuroprotective functions. However, in neurological and psychiatric disorders, it is often detrimental…”
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Ginkgo biloba leaf extract EGb 761 ® as a paragon of the product by process concept by Kulić, Žarko, Lehner, Martin D, Dietz, Gunnar P H

“…It is an often-neglected fact that extracts derived from the very same plant can differ significantly in their phytochemical composition, and thus also in…”
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Antiviral and Immunomodulatory Effects of Pelargonium sidoides DC. Root Extract EPs® 7630 in SARS-CoV-2-Infected Human Lung Cells by Papies, Jan, Emanuel, Jackson, Heinemann, Nicolas, Kulić, Žarko, Schroeder, Simon, Tenner, Beate, Lehner, Martin D, Seifert, Georg, Müller, Marcel A

“…Treatment options for COVID-19 are currently limited. Drugs reducing both viral loads and SARS-CoV-2-induced inflammatory responses would be ideal candidates…”
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Inhibition of inducible nitric oxide synthase in respiratory diseases by Hesslinger, Christian, Strub, Andreas, Boer, Rainer, Ulrich, Wolf-Rüdiger, Lehner, Martin D, Braun, Clemens

“…Nitric oxide (NO) is a key physiological mediator and disturbed regulation of NO release is associated with the pathophysiology of almost all inflammatory…”
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In vitro and in vivo effects of Pelargonium sidoides DC. root extract EPs ® 7630 and selected constituents against SARS-CoV-2 B.1, Delta AY.4/AY.117 and Omicron BA.2 by Emanuel, Jackson, Papies, Jan, Galander, Celine, Adler, Julia M, Heinemann, Nicolas, Eschke, Kathrin, Merz, Sophie, Pischon, Hannah, Rose, Ruben, Krumbholz, Andi, Kulić, Žarko, Lehner, Martin D, Trimpert, Jakob, Müller, Marcel A

“…The occurrence of immune-evasive SARS-CoV-2 strains emphasizes the importance to search for broad-acting antiviral compounds. Our previous study showed that…”
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Effects of a proprietary mixture of extracts from Sabal serrulata fruits and Urtica dioica roots (WS ®  1541) on prostate hyperplasia and inflammation in rats and human cells by Sens-Albert, Carla, Weisenburger, Sabrina, König, Beatrix C, Melcher, Silas F, Scheyhing, Ulrike A M, Rollet, Karin, Lluel, Philippe, Koch, Egon, Lehner, Martin D, Michel, Martin C

“…Phytotherapeutics, particularly extracts from (saw palmetto) fruit or (stinging nettle) root, are popular for the treatment of male lower urinary symptoms in…”
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Corrigendum: Antiviral and Immunomodulatory Effects of Pelargonium sidoides DC. Root Extract EPs ® 7630 in SARS-CoV-2-Infected Human Lung Cells by Papies, Jan, Emanuel, Jackson, Heinemann, Nicolas, Kulić, Žarko, Schroeder, Simon, Tenner, Beate, Lehner, Martin D, Seifert, Georg, Müller, Marcel A

“…[This corrects the article DOI: 10.3389/fphar.2021.757666.]…”
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Differential effects of CpG‐DNA in Toll‐like receptor‐2/‐4/‐9 tolerance and cross‐tolerance by Dalpke, Alexander H., Lehner, Martin D., Hartung, Thomas, Heeg, Klaus

“…Summary Lipopolysaccharide (LPS) tolerance is a state of refractoriness towards a second stimulation by LPS after a preceding stimulation. LPS is recognized by…”
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Induction of Cross-Tolerance by Lipopolysaccharide and Highly Purified Lipoteichoic Acid Via Different Toll-Like Receptors Independent of Paracrine Mediators by Lehner, Martin D, Morath, Siegfried, Michelsen, Kathrin S, Schumann, Ralf R, Hartung, Thomas

“…Exposure of macrophages to LPS induces a state of hyporesponsiveness to subsequent stimulation with LPS termed LPS desensitization or tolerance. To date, it is…”
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A tiered approach to investigate the mechanism of anti-inflammatory activity of an herbal medicinal product containing a fixed combination of thyme herb and primula root extracts by Seibel, Jan, Wonnemann, Meinolf, Werz, Oliver, Lehner, Martin D.

“…Background The herbal medicinal product Bronchipret® TP film-coated tablets contains a fixed combination of thyme and primula dry extracts (BRO) and has long…”
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Menthacarin treatment attenuates nociception in models of visceral hypersensitivity by Omoloye, Adesina, Weisenburger, Sabrina, Lehner, Martin D., Gronier, Benjamin

“…Background Chronic visceral hypersensitivity is closely associated with irritable bowel syndrome (IBS), a very common disorder which significantly impairs…”
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Pharmacologic treatments in preclinical tinnitus models with special focus on Ginkgo biloba leaf extract EGb 761 by Barth, Stephan W., Lehner, Martin D., Dietz, Gunnar P.H., Schulze, Holger

“…Tinnitus is defined as the perception of sound in the absence of external acoustic stimuli. Frequent comorbidities or associated factors are depression,…”
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Anti-inflammatory potential of PI3Kδ and JAK inhibitors in asthma patients by Southworth, Thomas, Plumb, Jonathan, Gupta, Vandana, Pearson, James, Ramis, Isabel, Lehner, Martin D, Miralpeix, Montserrat, Singh, Dave

“…Phosphatidylinositol 3-kinase delta (PI3Kδ) and Janus-activated kinases (JAK) are both novel anti-inflammatory targets in asthma that affect lymphocyte…”
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Mitogen-Activated Protein Kinase-Activated Protein Kinase 2-Deficient Mice Show Increased Susceptibility to Listeria monocytogenes Infection by Lehner, Martin D, Schwoebel, Frank, Kotlyarov, Alexey, Leist, Marcel, Gaestel, Matthias, Hartung, Thomas

“…Mitogen-activated protein kinase-activated protein kinase 2 (MK2) is one of several kinases activated through direct phosphorylation by p38 mitogen-activated…”
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Inhibition of Cyclooxygenase-2 by Natriuretic Peptides by Kiemer, Alexandra K, Lehner, Martin D, Hartung, Thomas, Vollmar, Angelika M

“…The atrial natriuretic peptide (ANP) has been suggested to possess immunomodulatory potential because of its property to alter macrophage functions via its…”
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Improved Innate Immunity of Endotoxin-Tolerant Mice Increases Resistance to Salmonella enterica Serovar Typhimurium Infection despite Attenuated Cytokine Response by LEHNER, Martin D, ITTNER, Josepha, BUNDSCHUH, Daniela S, VAN ROOIJEN, Nico, WENDEL, Albrecht, HARTUNG, Thomas

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Bronchipret® syrup containing thyme and ivy extracts suppresses bronchoalveolar inflammation and goblet cell hyperplasia in experimental bronchoalveolitis by Seibel, Jan, Pergola, Carlo, Werz, Oliver, Kryshen, Kirill, Wosikowski, Katja, Lehner, Martin D., Haunschild, Jutta

“…Acute bronchitis (AB) is a common lung condition characterized by inflammation of the large bronchi in response to infection. Bronchipret® syrup (BRO), a fixed…”
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PDE4 inhibitors: a review of current developments (2005 - 2009) by Pagès, Lluís, Gavaldà, Amadeu, Lehner, Martin D

“…Despite the sound preclinical database and some promising data from clinical trials, development of PDE4 inhibitors for the treatment of inflammatory or…”
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