Search Results - "Lehmann‐Werman, Roni"
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A universal cell‐free DNA approach for response prediction to preoperative chemoradiation in rectal cancer
Published in International journal of cancer (01-04-2023)“…The standard treatment approach for stage II/III rectal cancer is neoadjuvant chemoradiation therapy (nCRT) followed by surgery. In recent years, new treatment…”
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Identification of tissue-specific cell death using methylation patterns of circulating DNA
Published in Proceedings of the National Academy of Sciences - PNAS (29-03-2016)“…Minimally invasive detection of cell death could prove an invaluable resource in many physiologic and pathologic situations. Cell-free circulating DNA (cfDNA)…”
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Monitoring liver damage using hepatocyte-specific methylation markers in cell-free circulating DNA
Published in JCI insight (21-06-2018)“…Liver damage is typically inferred from serum measurements of cytoplasmic liver enzymes. DNA molecules released from dying hepatocytes are an alternative…”
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Protein biomarkers and alternatively methylated cell-free DNA detect early stage pancreatic cancer
Published in Gut (13-12-2023)“…Pancreatic ductal adenocarcinoma (PDAC) is commonly diagnosed at an advanced stage. Liquid biopsy approaches may facilitate detection of early stage PDAC when…”
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NCMP-24. BRAIN-DERIVED CIRCULATING DNA AS A BIOMARKER FOR RADIOTHERAPY-INDUCED BRAIN DAMAGE
Published in Neuro-oncology (Charlottesville, Va.) (05-11-2018)“…Abstract INTRODUCTION Radiotherapy is a common treatment for brain metastases. However, it is commonly associated with central nervous system (CNS) toxicity…”
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Liquid biopsy reveals collateral tissue damage in cancer
Published in JCI insight (25-01-2022)“…Cancer inflicts damage to surrounding normal tissues, which can culminate in fatal organ failure. Here, we demonstrate that cell death in organs affected by…”
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