Search Results - "Lehmann, Thomas‐Nicolas"

Early volumetric changes of hippocampus and medial prefrontal cortex following medial temporal lobe resection by Pajkert, Anna, Ploner, Christoph J., Lehmann, Thomas‐Nicolas, Witte, Veronica A., Oltmanns, Frank, Sommer, Werner, Holtkamp, Martin, Heekeren, Hauke R., Finke, Carsten

“…Previous studies have shown that cognitive demands and physical exercise stimulate adult neurogenesis in the dentate gyrus and hippocampus. Recent observations…”
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Differential effects of temporal pole resection with amygdalohippocampectomy versus selective amygdalohippocampectomy on material‐specific memory in patients with mesial temporal lobe epilepsy by Helmstaedter, Christoph, Richter, Sabine, Röske, Sandra, Oltmanns, Frank, Schramm, Johannes, Lehmann, Thomas‐Nicolas

“…Summary Purpose: In the surgical treatment of mesial temporal lobe epilepsy, there is converging evidence that individually tailored or selective approaches…”
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Delayed ischaemic neurological deficits after subarachnoid haemorrhage are associated with clusters of spreading depolarizations by Dreier, Jens P., Woitzik, Johannes, Fabricius, Martin, Bhatia, Robin, Major, Sebastian, Drenckhahn, Chistoph, Lehmann, Thomas-Nicolas, Sarrafzadeh, Asita, Willumsen, Lisette, Hartings, Jed A., Sakowitz, Oliver W., Seemann, Jörg H., Thieme, Anja, Lauritzen, Martin, Strong, Anthony J.

“…Progressive ischaemic damage in animals is associated with spreading mass depolarizations of neurons and astrocytes, detected as spreading negative slow…”
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Glycinergic tonic inhibition of hippocampal neurons with depolarizing GABAergic transmission elicits histopathological signs of temporal lobe epilepsy by Eichler, Sabrina A., Kirischuk, Sergei, Jüttner, René, Schafermeier, Philipp K., Legendre, Pascal, Lehmann, Thomas‐Nicolas, Gloveli, Tengis, Grantyn, Rosemarie, Meier, Jochen C.

“…An increasing number of epilepsy patients are afflicted with drug‐resistant temporal lobe epilepsy (TLE) and require alternative therapeutic approaches…”
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Splice-specific roles of glycine receptor α3 in the hippocampus by Eichler, Sabrina A., Förstera, Benjamin, Smolinsky, Birthe, Jüttner, René, Lehmann, Thomas-Nicolas, Fähling, Michael, Schwarz, Günter, Legendre, Pascal, Meier, Jochen C.

“…Glycine receptor (GlyR) α3 is involved in vision, and processing of acoustic and nociceptive signals, and RNA editing of GLRA3 transcripts was associated with…”
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Hyperpolarization‐activated cation currents in human epileptogenic neocortex by Wierschke, Stephan, Lehmann, Thomas‐Nicolas, Dehnicke, Christoph, Horn, Peter, Nitsch, Robert, Deisz, Rudolf A.

“…Summary Purpose:  Hyperpolarization‐activated cation currents (IH) play a pivotal role in the control of neuronal excitability. In animal models of epilepsy…”
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Nitric Oxide Modulates Spreading Depolarization Threshold in the Human and Rodent Cortex by PETZOLD, Gabor C, HAACK, Stephan, VON BOHLEN UND HALBACH, Oliver, PRILLER, Josef, LEHMANN, Thomas-Nicolas, HEINEMANN, Uwe, DIMAGL, Ulrich, DREIER, Jens P

“…Recent clinical data have suggested that prolonged cortical spreading depolarizations (CSDs) contribute to the pathogenesis of delayed ischemic neurologic…”
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Metabolic dysfunction during neuronal activation in the ex vivo hippocampus from chronic epileptic rats and humans by Kann, Oliver, Kovács, Richard, Njunting, Marleisje, Behrens, Christoph Joseph, Otáhal, Jakub, Lehmann, Thomas-Nicolas, Gabriel, Siegrun, Heinemann, Uwe

“…Metabolic dysfunction has been implicated in the pathogenesis of temporal lobe epilepsy (TLE), but its manifestation during neuronal activation in the ex vivo…”
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Impaired function of GABAB receptors in tissues from pharmacoresistant epilepsy patients by Teichgräber, Laura A., Lehmann, Thomas‐Nicolas, Meencke, Heinz‐Joachim, Weiss, Torsten, Nitsch, Robert, Deisz, Rudolf A.

“…Summary Purpose:  Effects of pre‐ and postsynaptic γ‐aminobutyric acid B (GABAB) receptor activation were characterized in human tissue from epilepsy surgery…”
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Lesions affecting the right hippocampal formation differentially impair short-term memory of spatial and nonspatial associations by Braun, Mischa, Weinrich, Christiane, Finke, Carsten, Ostendorf, Florian, Lehmann, Thomas-Nicolas, Ploner, Christoph J.

“…Converging evidence from behavioral and imaging studies suggests that within the human medial temporal lobe (MTL) the hippocampal formation may be particularly…”
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Evaluating reference genes to normalize gene expression in human epileptogenic brain tissues by Wierschke, Stephan, Gigout, Sylvain, Horn, Peter, Lehmann, Thomas-Nicolas, Dehnicke, Christoph, Bräuer, Anja U., Deisz, Rudolf A.

“…► To quantify gene expression in human epilepsy tissues reliable reference genes are necessary but have not been established yet. ► geNorm analysis of our data…”
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Reorganization of associative memory in humans with long-standing hippocampal damage by Braun, Mischa, Finke, Carsten, Ostendorf, Florian, Lehmann, Thomas-Nicolas, Hoffmann, Karl-Titus, Ploner, Christoph J.

“…Conflicting theories have been advanced to explain why hippocampal lesions affect distinct memory domains and spare others. Recent findings in monkeys suggest…”
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The Subiculum: A Potential Site of Ictogenesis in Human Temporal Lobe Epilepsy by Wozny, Christian, Knopp, Andreas, Lehmann, Thomas‐Nicolas, Heinemann, Uwe, Behr, Joachim

“…Purpose: This study determines synaptic and intrinsic alterations of subicular pyramidal cells that are associated with activity recorded in patients suffering…”
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Carbamazepine-resistance in the epileptic dentate gyrus of human hippocampal slices by Jandová, Katerina, Päsler, Dennis, Antonio, Leandro Leite, Raue, Claudia, Ji, Shengbo, Njunting, Marleisje, Kann, Oliver, Kovács, Richard, Meencke, Heinz-Joachim, Cavalheiro, Esper A., Heinemann, Uwe, Gabriel, Siegrun, Lehmann, Thomas-Nicolas

“…Overexpression of drug efflux pumps at the blood brain barrier (BBB) has been suggested to be one important factor contributing to drug resistance in epilepsy…”
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Glutamine induces epileptiform discharges in superficial layers of the medial entorhinal cortex from pilocarpine‐treated chronic epileptic rats in vitro by Sandow, Nora, Zahn, Robert K., Gabriel, Siegrun, Heinemann, Uwe, Lehmann, Thomas‐Nicolas

“…Summary Purpose:  Glutamine (GLN) is a precursor for synthesis of glutamate and γ‐aminobutyric acid (GABA) and has been found in the cerebrospinal fluid (CSF)…”
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Seizure outcome 1 year after temporal lobe epilepsy: an analysis of MR volumetric and clinical parameters by Mueller, Christian-Andreas, Scorzin, Jasmin, von Lehe, Marec, Fimmers, Rolf, Helmstaedter, Christoph, Zentner, Josef, Lehmann, Thomas-Nicolas, Meencke, Heinz-Joachim, Schulze-Bonhage, Andreas, Schramm, Johannes

“…Background The aim of this work was to determine predictors that may contribute to surgical success or failure. Relevant pre- and postoperative baseline data…”
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Comparison of manual tracing versus a semiautomatic radial measurement method in temporal lobe MRI volumetry for pharmacoresistant epilepsy by MUELLER, Christian-Andreas, SCORZIN, Jasmin, KOENIG, Roy, URBACH, Horst, FIMMERS, Rolf, ZENTNER, Josef, LEHMANN, Thomas-Nicolas, SCHRAMM, Johannes

“…The aim of this study was to test a modified radial semiautomated volumetry technique (radial divider technique, RDT) versus the manual volumetry technique…”
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The human hippocampal formation mediates short-term memory of colour–location associations by Finke, Carsten, Braun, Mischa, Ostendorf, Florian, Lehmann, Thomas-Nicolas, Hoffmann, Karl-Titus, Kopp, Ute, Ploner, Christoph J.

“…The medial temporal lobe (MTL) has long been considered essential for declarative long-term memory, whereas the fronto-parietal cortex is generally seen as the…”
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Stimulus and Potassium-Induced Epileptiform Activity in the Human Dentate Gyrus from Patients with and without Hippocampal Sclerosis by Gabriel, Siegrun, Njunting, Marleisje, Pomper, Joern K, Merschhemke, Martin, Sanabria, Emilio R. G, Eilers, Alexander, Kivi, Anatol, Zeller, Melanie, Meencke, Heinz-Joachim, Cavalheiro, Esper A, Heinemann, Uwe, Lehmann, Thomas-Nicolas

“…Hippocampal specimens resected to cure medically intractable temporal lobe epilepsy (TLE) provide a unique possibility to study functional consequences of…”
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Drug resistance in cortical and hippocampal slices from resected tissue of epilepsy patients: no significant impact of p-glycoprotein and multidrug resistance-associated proteins by Sandow, Nora, Kim, Simon, Raue, Claudia, Päsler, Dennis, Klaft, Zin-Juan, Antonio, Leandro Leite, Hollnagel, Jan Oliver, Kovacs, Richard, Kann, Oliver, Horn, Peter, Vajkoczy, Peter, Holtkamp, Martin, Meencke, Heinz-Joachim, Cavalheiro, Esper A, Pragst, Fritz, Gabriel, Siegrun, Lehmann, Thomas-Nicolas, Heinemann, Uwe

“…Drug resistant patients undergoing epilepsy surgery have a good chance to become sensitive to anticonvulsant medication, suggesting that the resected brain…”
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