Search Results - "Lehmann, Susann"

Enhancing NAD + salvage metabolism is neuroprotective in a PINK1 model of Parkinson's disease by Lehmann, Susann, Loh, Samantha H Y, Martins, L Miguel

“…Familial forms of Parkinson's disease (PD) caused by mutations in are linked to mitochondrial impairment. Defective mitochondria are also found in models of PD…”
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dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective by Celardo, Ivana, Lehmann, Susann, Costa, Ana C, Loh, Samantha HY, Miguel Martins, L

“…Neurons rely on mitochondria as their preferred source of energy. Mutations in PINK1 and PARKIN cause neuronal death in early-onset Parkinson’s disease (PD),…”
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Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease by Tufi, Roberta, Gandhi, Sonia, de Castro, Inês P., Lehmann, Susann, Angelova, Plamena R., Dinsdale, David, Deas, Emma, Plun-Favreau, Hélène, Nicotera, Pierluigi, Abramov, Andrey Y., Willis, Anne E., Mallucci, Giovanna R., Loh, Samantha H. Y., Martins, L. Miguel

“…Mutations in PINK1 cause early-onset Parkinson’s disease (PD). Studies in Drosophila melanogaster have highlighted mitochondrial dysfunction on loss of Pink1…”
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Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin by Garrido-Maraver, Juan, Celardo, Ivana, Costa, Ana C., Lehmann, Susann, Loh, Samantha H. Y., Martins, L. Miguel

“…Mutations in the mitochondrial GTPase mitofusin 2 (MFN2) cause Charcot-Marie-Tooth disease type 2 (CMT2A), a form of peripheral neuropathy that compromises…”
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Viability and Functionality of Neonatal Porcine Islet-like Cell Clusters Bioprinted in Alginate-Based Bioinks by Duin, Sarah, Bhandarkar, Shreya, Lehmann, Susann, Kemter, Elisabeth, Wolf, Eckhard, Gelinsky, Michael, Ludwig, Barbara, Lode, Anja

“…The transplantation of pancreatic islets can prevent severe long-term complications in diabetes mellitus type 1 patients. With respect to a shortage of donor…”
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Monitoring of molecular responses to tirabrutinib in a cohort of exceptional responders with relapsed/refractory mantle cell lymphoma by Alqahtani, Abdullah N. M., Jayne, Sandrine, Ahearne, Matthew J., Trethewey, Christopher S., Duraisingham, Sai S., Lehmann, Susann, Cowley, Caroline M., Dyer, Martin J. S., Walter, Harriet S.

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Transplantation of pancreatic islets to adrenal gland is promoted by agonists of growth-hormone-releasing hormone by Schubert, Undine, Schmid, Janine, Lehmann, Susann, Zhang, Xian Y., Morawietz, Henning, Block, Norman L., Kanczkowski, Waldemar, Schally, Andrew V., Bornstein, Stefan R., Ludwig, Barbara

“…Here, we evaluate an alternative approach of preconditioning pancreatic islets before transplantation using a potent agonist of growth-hormone-releasing…”
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Calpains mediate integrin attachment complex maintenance of adult muscle in Caenorhabditis elegans by Etheridge, Timothy, Oczypok, Elizabeth A, Lehmann, Susann, Fields, Brandon D, Shephard, Freya, Jacobson, Lewis A, Szewczyk, Nathaniel J

“…Two components of integrin containing attachment complexes, UNC-97/PINCH and UNC-112/MIG-2/Kindlin-2, were recently identified as negative regulators of muscle…”
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Knockdown of the C. elegans kinome identifies kinases required for normal protein homeostasis, mitochondrial network structure, and sarcomere structure in muscle by Lehmann, Susann, Bass, Joseph J, Szewczyk, Nathaniel J

“…Kinases are important signalling molecules for modulating cellular processes and major targets of drug discovery programs. However, functional information for…”
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Functional phosphatome requirement for protein homeostasis, networked mitochondria, and sarcomere structure in C. elegans muscle by Lehmann, Susann, Bass, Joseph J., Barratt, Thomas F., Ali, Mohammed Z., Szewczyk, Nathaniel J.

“…Background Skeletal muscle is central to locomotion and metabolic homeostasis. The laboratory worm Caenorhabditis elegans has been developed into a genomic…”
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3D Bioprinting of Functional Islets of Langerhans in an Alginate/Methylcellulose Hydrogel Blend by Duin, Sarah, Schütz, Kathleen, Ahlfeld, Tilman, Lehmann, Susann, Lode, Anja, Ludwig, Barbara, Gelinsky, Michael

“…Transplantation of pancreatic islets is a promising strategy to alleviate the unstable blood‐glucose control that some patients with diabetes type 1 exhibit…”
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Integrated control of protein degradation in C. elegans muscle by Lehmann, Susann, Shephard, Freya, Jacobson, Lewis A., Szewczyk, Nathaniel J.

“…Protein degradation is a fundamental cellular process, the genomic control of which is incompletely understood. The advent of transgene-coded reporter proteins…”
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The Adrenal Gland and Pancreatic Islets - A Beneficial Endocrine Alliance by Schubert, Undine, Lehmann, Susann, Schmid, Janine, Morawietz, Henning, Bornstein, Stefan R, Ludwig, Barbara

“…Intraportal islet transplantation in patients with type 1 diabetes enables restoration of glucose-regulated insulin secretion. However, several factors hamper…”
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Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes by Ludwig, Barbara, Ludwig, Stefan, Steffen, Anja, Knauf, Yvonne, Zimerman, Baruch, Heinke, Sophie, Lehmann, Susann, Schubert, Undine, Schmid, Janine, Bleyer, Martina, Schönmann, Uwe, Colton, Clark K., Bonifacio, Ezio, Solimena, Michele, Reichel, Andreas, Schally, Andrew V., Rotem, Avi, Barkai, Uriel, Grinberg-Rashi, Helena, Kaup, Franz-Josef, Avni, Yuval, Jones, Peter, Bornstein, Stefan R.

“…Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for…”
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203.4: Generation and Characterization of Porcine derived Pseudo-Islets for Islet-cell Replacement by Abdelgawad, Hany, Schubert, Undine, Chawla, Prateek, Kraetzl, Martin, Schmid, Janine, Lehmann, Susann, Cohrs, Christian, Ninov, Nikolay, Alves, Tiago, Bornstein, Stefan, Kemter, Elisabeth, Ludwig, Barbara

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Mechanistic Insights into Ferroptotic Cell Death in Pancreatic Islets by Schepp, Florian, Schubert, Undine, Schmid, Janine, Lehmann, Susann, Latunde-Dada, Gladys Oluyemisi, Kose, Tugba, Steenblock, Charlotte, Bornstein, Stefan R, Linkermann, Andreas, Ludwig, Barbara

“…Ferroptosis was recently identified as a non-apoptotic, iron-dependent cell death mechanism that is involved in various pathologic conditions. There is first…”
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Abstract 4143744: Cross-talk between oxidized LDL, oxidative stress and renin-angiotensin-aldosterone system: Impact on endothelial function and atherosclerosis by Catar, Rusan, Kamhieh-Milz, Julian, Goettsch, Claudia, Chen, Lei, Zickler, Daniel, Taye, Ashraf, Hofmann, Anja, Brunssen, Coy, Muller, Gregor, Cybularz, Maria, Hengst, Clara, Villar Ballesteros, Maria de Leyre, Lehmann, Susann, Schubert, Undine, Ludwig, Barbara, Ziegler, Christian, Bornstein, Stefan, Krug, Alexander, Walther, Thomas, Moll, Guido, Morawietz, Henning

“…Abstract only Introduction/Background: Hypertension and hypercholesterolemia are important risk factors of endothelial dysfunction and atherosclerosis…”
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Transplantation of porcine adrenal spheroids for the treatment of adrenal insufficiency by Malyukov, Maria, Gelfgat, Evgeny, Ruiz-Babot, Gerard, Schmid, Janine, Lehmann, Susann, Spinas, Giatgen, Beuschlein, Felix, Hantel, Constanze, Reisch, Nicole, Nawroth, Peter P, Bornstein, Stefan R, Steenblock, Charlotte, Ludwig, Barbara

“…Primary adrenal insufficiency is a life-threatening disorder, which requires lifelong hormone replacement therapy. Transplantation of xenogeneic adrenal cells…”
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Insights into mitochondrial quality control pathways and Parkinson’s disease by Lehmann, Susann, Martins, L. Miguel

“…The brain uses more energy than any other human organ, accounting for 20 % of the body’s total demand. Mitochondria are energy-converting organelles with a…”
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Author Correction: ATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective by Celardo, Ivana, Lehmann, Susann, Costa, Ana C., Loh, Samantha H. Y., Martins, L. Miguel

“…Following publication of the article, Dr. Roberta Tufi of the Mitochondrial Biology Unit at the University of Cambridge was concerned to note that her own…”
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