Search Results - "Lehman, Michael N"

Minireview: Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cells of the Arcuate Nucleus: A Central Node in the Control of Gonadotropin-Releasing Hormone Secretion by Lehman, Michael N, Coolen, Lique M, Goodman, Robert L

“…Recently, a subset of neurons was identified in the arcuate nucleus of the hypothalamus that colocalize three neuropeptides, kisspeptin, neurokinin B, and…”
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In vivo imaging of the GnRH pulse generator reveals a temporal order of neuronal activation and synchronization during each pulse by Moore, Aleisha M, Coolen, Lique M, Lehman, Michael N

“…A hypothalamic pulse generator located in the arcuate nucleus controls episodic release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH)…”
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Kisspeptin/Neurokinin B/Dynorphin (KNDy) cells as integrators of diverse internal and external cues: evidence from viral-based monosynaptic tract-tracing in mice by Moore, Aleisha M., Coolen, Lique M., Lehman, Michael N.

“…Neurons in the hypothalamic arcuate nucleus (ARC) that co-express kisspeptin, neurokinin B and dynorphin (KNDy cells) are essential for mammalian reproduction…”
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Neuroendocrine control of gonadotropin‐releasing hormone: Pulsatile and surge modes of secretion by Goodman, Robert L., Herbison, Allan E., Lehman, Michael N., Navarro, Victor M.

“…The concept that different systems control episodic and surge secretion of gonadotropin‐releasing hormone (GnRH) was well established by the time that GnRH was…”
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Neuroanatomy of the kisspeptin signaling system in mammals: comparative and developmental aspects by Lehman, Michael N, Hileman, Stanley M, Goodman, Robert L

“…Our understanding of kisspeptin and its actions depends, in part, on a detailed knowledge of the neuroanatomy of the kisspeptin signaling system in the brain…”
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Kisspeptin Neurons from Mice to Men: Similarities and Differences by Goodman, Robert L, Lehman, Michael N

“…The discovery that kisspeptin was critical for normal fertility in humans ushered in a new chapter in our understanding of the control of GnRH secretion. In…”
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The Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cell Population of the Arcuate Nucleus: Sex Differences and Effects of Prenatal Testosterone in Sheep by Cheng, Guanliang, Coolen, Lique M, Padmanabhan, Vasantha, Goodman, Robert L, Lehman, Michael N

“…Recent work in sheep has identified a neuronal subpopulation in the arcuate nucleus that coexpresses kisspeptin, neurokinin B, and dynorphin (referred to here…”
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Kisspeptin, Neurokinin B, and Dynorphin Act in the Arcuate Nucleus to Control Activity of the GnRH Pulse Generator in Ewes by Goodman, Robert L, Hileman, Stanley M, Nestor, Casey C, Porter, Katrina L, Connors, John M, Hardy, Steve L, Millar, Robert P, Cernea, Maria, Coolen, Lique M, Lehman, Michael N

“…Recent work has led to the hypothesis that kisspeptin/neurokinin B/dynorphin (KNDy) neurons in the arcuate nucleus play a key role in GnRH pulse generation,…”
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Anatomy of the kisspeptin neural network in mammals by Lehman, Michael N, Merkley, Christina M, Coolen, Lique M, Goodman, Robert L

“…Abstract Kisspeptin has been recognized as a key regulator of GnRH secretion during puberty and adulthood, conveying the feedback influence of endogenous…”
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Regulation of GnRH pulsatility in ewes by Nestor, Casey C, Bedenbaugh, Michelle N, Hileman, Stanley M, Coolen, Lique M, Lehman, Michael N, Goodman, Robert L

“…Early work in ewes provided a wealth of information on the physiological regulation of pulsatile gonadotropin-releasing hormone (GnRH) secretion by internal…”
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KNDy (Kisspeptin/Neurokinin B/Dynorphin) Neurons Are Activated during Both Pulsatile and Surge Secretion of LH in the Ewe by Merkley, Christina M, Porter, Katrina L, Coolen, Lique M, Hileman, Stanley M, Billings, Heather J, Drews, Sara, Goodman, Robert L, Lehman, Michael N

“…KNDy (kisspeptin/neurokinin B/dynorphin) neurons of the arcuate nucleus (ARC) appear to mediate the negative feedback actions of estradiol and are thought to…”
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Molecular Mapping of the Neural Pathways Linking Leptin to the Neuroendocrine Reproductive Axis by Louis, Gwendolyn W, Greenwald-Yarnell, Megan, Phillips, Rebecca, Coolen, Lique M, Lehman, Michael N, Myers, Martin G

“…Leptin communicates with the neuroendocrine reproductive axis via multiple populations of LepRb neurons that lie afferent to both Kiss1 and GnRH neurons…”
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A role for neurokinin B in pulsatile GnRH secretion in the ewe by Goodman, Robert L, Coolen, Lique M, Lehman, Michael N

“…The recent description of infertility in humans with loss-of-function mutations in genes for neurokinin B (NKB) or its receptor (NK3R) has focused attention on…”
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Variation in Kisspeptin and RFamide-Related Peptide (RFRP) Expression and Terminal Connections to Gonadotropin-Releasing Hormone Neurons in the Brain: A Novel Medium for Seasonal Breeding in the Sheep by Smith, Jeremy T, Coolen, Lique M, Kriegsfeld, Lance J, Sari, Ika P, Jaafarzadehshirazi, Mohammad R, Maltby, Matthew, Bateman, Katherine, Goodman, Robert L, Tilbrook, Alan J, Ubuka, Takayoshi, Bentley, George E, Clarke, Iain J, Lehman, Michael N

“…Reproductive activity in sheep is seasonal, being activated by short-day photoperiods and inhibited by long days. During the nonbreeding season, GnRH secretion…”
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Kisspeptin Neurons in the Arcuate Nucleus of the Ewe Express Both Dynorphin A and Neurokinin B by Goodman, Robert L, Lehman, Michael N, Smith, Jeremy T, Coolen, Lique M, de Oliveira, Cleusa V. R, Jafarzadehshirazi, Mohammad R, Pereira, Alda, Iqbal, Javed, Caraty, Alain, Ciofi, Philippe, Clarke, Iain J

“…Kisspeptin is a potent stimulator of GnRH secretion that has been implicated in the feedback actions of ovarian steroids. In ewes, the majority of hypothalamic…”
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Does the KNDy Model for the Control of Gonadotropin-Releasing Hormone Pulses Apply to Monkeys and Humans? by Lehman, Michael N, He, Wen, Coolen, Lique M, Levine, Jon E, Goodman, Robert L

“…There is now considerable evidence supporting the role of a subpopulation of neurons in the arcuate nucleus of the hypothalamus that coexpress kisspeptin,…”
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Evaluation of the effectiveness of 3D vascular stereoscopic models in anatomy instruction for first year medical students by Cui, Dongmei, Wilson, Timothy D., Rockhold, Robin W., Lehman, Michael N., Lynch, James C.

“…The head and neck region is one of the most complex areas featured in the medical gross anatomy curriculum. The effectiveness of using three‐dimensional (3D)…”
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Food Entrainment, Arousal, and Motivation in the Neonatal Rabbit Pup by Caba, Mario, Lehman, Michael N, Caba-Flores, Mario Daniel

“…In the newborn rabbit, the light entrainable circadian system is immature and once a day nursing provides the primary timing cue for entrainment. In advance of…”
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Neurokinin B Acts via the Neurokinin-3 Receptor in the Retrochiasmatic Area to Stimulate Luteinizing Hormone Secretion in Sheep by Billings, Heather J, Connors, John M, Altman, Stephanie N, Hileman, Stanley M, Holaskova, Ida, Lehman, Michael N, McManus, Christina J, Nestor, Casey C, Jacobs, Britni H, Goodman, Robert L

“…Recent data have demonstrated that mutations in the receptor for neurokinin B (NKB), the NK-3 receptor (NK3R), produce hypogonadotropic hypogonadism in humans…”
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Prenatal androgen treatment impairs the suprachiasmatic nucleus arginine-vasopressin to kisspeptin neuron circuit in female mice by Jamieson, Bradley B, Moore, Aleisha M, Lohr, Dayanara B, Thomas, Simone X, Coolen, Lique M, Lehman, Michael N, Campbell, Rebecca E, Piet, Richard

“…Polycystic ovary syndrome (PCOS) is associated with elevated androgen and luteinizing hormone (LH) secretion and with oligo/anovulation. Evidence indicates…”
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