Search Results - "Lehman, L D"

Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia by O'DOHERTY, R. M, LEHMAN, D. L, TELEMAQUE-POTTS, S, NEWGARD, C. B

“…Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia. R M O'Doherty , D L Lehman , S…”
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Differential Induction of Apoptosis in Lymphoid Tissues During Sepsis: Variation in Onset, Frequency, and the Nature of the Mediators by Ayala, Alfred, Herdon, Crystal D., Lehman, Donna L., Ayala, Carol A., Chaudry, Irshad H.

“…Apoptosis (Ao), is a process by which cells undergo a form of nonnecrotic cellular suicide. Although for most cells this is a constitutive process, it can be…”
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Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2/IFN-gamma release while increasing IL-4/IL-10 production by Ayala, A, Deol, Z K, Lehman, D L, Herdon, C D, Chaudry, I H

“…Although studies indicate that polymicrobial sepsis produces marked depression in lymphocyte functions, it remains unclear whether this dysfunction is due to…”
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Choline supplementation inhibits diethanolamine-induced morphological transformation in Syrian hamster embryo cells : Evidence for a carcinogenic mechanism by LEHMAN-MCKEEMAN, L. D, GAMSKY, E. A

“…DEA, an amino alcohol, and its fatty acid condensates are widely used in commerce. DEA is hepatocarcinogenic in mice, but shows no evidence of mutagenicity or…”
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Diethanolamine Induces Hepatic Choline Deficiency in Mice by Lehman-McKeeman, Lois D., Gamsky, Elizabeth A., Hicks, Sarah M., Vassallo, Jeffrey D., Mar, Mei-Heng, Zeisel, Steven H.

“…The purpose of the present experiments was to test the hypothesis that diethanolamine (DEA), an alkanolamine shown to be hepatocarcinogenic in mice, induces…”
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In vitro kinetics of coumarin 3,4-epoxidation : Application to species differences in toxicity and carcinogenicity by BORN, Stephanie L, CAUDILL, Douglas, SMITH, Bill J, LEHMAN-MCKEEMAN, Lois D

“…Coumarin, a natural product and fragrance ingredient, is a well recognized rat liver toxicant, and dietary administration at toxic dosages increased the…”
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o-Hydroxyphenylacetaldehyde Is a Hepatotoxic Metabolite of Coumarin by Born, S L, Hu, J K, Lehman-McKeeman, L D

“…o -Hydroxyphenylacetaldehyde ( o -HPA), the product of coumarin 3,4-epoxide, was synthesized and its contribution to the hepatotoxic effects of coumarin in the…”
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Dosage-dependent disposition of cadmium administered orally to rats by Lehman, L D, Klaassen, C D

“…This study was designed to determine whether the disposition of Cd is dependent on dose. Rats received a single dosage of Cd either orally (1, 10, 100, 1000,…”
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Metallothionein gene regulation in the preimplantation rabbit blastocyst by Andrews, G K, Huet, Y M, Lehman, L D, Dey, S K

“…Expression of metallothionein (MT) genes in the preimplantation rabbit blastocyst was analysed by determination of the levels of MT mRNA and relative rates of…”
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Separation and quantitation of metallothioneins by high-performance liquid chromatography coupled with atomic absorption spectrophotometry by Lehman, L D, Klaassen, C D

“…A rapid, reproducible, and sensitive high-performance liquid chromatography (HPLC) method for the determination of the concentrations of metallothionein-I…”
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Selective Clara cell injury in mouse lung following acute administration of coumarin by BORN, S. L, FIX, A. S, CAUDILL, D, LEHMAN-MCKEEMAN, L. D

“…Coumarin is a known hepatotoxicant in laboratory animals, particularly rats. However, the mouse lung was identified as a major target organ in a chronic…”
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Development of tolerance to Clara cell necrosis with repeat administration of coumarin by BORN, S. L, FIX, A. S, CAUDILL, D, LEHMAN-MCKEEMAN, L. D

“…Coumarin was identified as a mouse-lung carcinogen following oral gavage administration in a chronic bioassay, and was shown to cause the selective necrosis of…”
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The induction of accelerated thymic programmed cell death during polymicrobial sepsis: control by corticosteroids but not tumor necrosis factor by Ayala, A, Herdon, C D, Lehman, D L, DeMaso, C M, Ayala, C A, Chaudry, I H

“…Thymic programmed cell death (PCD) or apoptosis (Ao) is elevated during inflammation by a variety of stressors in vitro (i.e., glucocorticoids, tumor necrosis…”
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Differential Metabolic Effects of Adenovirus-mediated Glucokinase and Hexokinase I Overexpression in Rat Primary Hepatocytes by O'Doherty, Robert M., Lehman, Donna L., Seoane, Joan, Gómez-Foix, Anna M., Guinovart, Joan J., Newgard, Christopher B.

“…The first step of glucose metabolism is the phosphorylation of glucose, catalyzed by the hexokinase family of enzymes. To address the metabolic impact of…”
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Induction of hepatic metallothionein following administration of urethane by Brzeznicka, E A, Lehman, L D, Klaassen, C D

“…Induction of hepatic metallothionein (MT) by urethane (ethyl carbamate) was characterized. Male CF-1 mice were treated with urethane (0, 0.5, 1.0, 1.5, and 2…”
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alpha 2-Urinary globulin-associated nephropathy as a mechanism of renal tubule cell carcinogenesis in male rats by Swenberg, J A, Lehman-McKeeman, L D

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Induction of hepatic metallothioneins determined at isoprotein and messenger RNA levels in glucocorticoid-treated rats by Lehman-McKeeman, L D, Andrews, G K, Klaassen, C D

“…Induction of metallothionein-I (MT-I) and metallothionein-II (MT-II) by glucocorticoids was determined by h.p.l.c. analysis of proteins and Northern-blot…”
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Preliminary results of immunization against Schistosoma mansoni with intermediate host antigen by Lehman, D L, Ruaini, G M

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Synthesis and Reactivity of Coumarin 3,4-Epoxide by Stephanie L. Born, Pedro A. Rodriguez, Cynthia L. Eddy, Lois D. Lehman-McKeeman

“…Coumarin is used widely as a fragrance constituent and is administered clinically in the treatment of certain lymphedemas and malignancies. Although toxicity…”
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Induction of metallothionein synthesis in cultured human trophoblasts by cadmium and zinc by Lehman, L D, Poisner, A M

“…A system of primary cultures of human chorionic trophoblasts has been used for studying the effects of heavy metals on human reproductive tissue. Using this…”
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