Search Results - "Lehman, John J"

PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis by Leone, Teresa C, Lehman, John J, Finck, Brian N, Schaeffer, Paul J, Wende, Adam R, Boudina, Sihem, Courtois, Michael, Wozniak, David F, Sambandam, Nandakumar, Bernal-Mizrachi, Carlos, Chen, Zhouji, Holloszy, John O, Medeiros, Denis M, Schmidt, Robert E, Saffitz, Jeffrey E, Abel, E Dale, Semenkovich, Clay F, Kelly, Daniel P

“…The gene encoding the transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) was targeted in mice…”
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Transcriptional Activation Of Energy Metabolic Switches In The Developing And Hypertrophied Heart by Lehman, John J, Kelly, Daniel P

“…SUMMARY 1. The present review focuses on the gene regulatory mechanisms involved in the control of cardiac mitochondrial energy production in the developing…”
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Chronic caloric restriction attenuates a loss of sulfatide content in PGC-1α mouse cortex: a potential lipidomic role of PGC-1α in neurodegeneration by Kiebish, Michael A., Young, Dee M., Lehman, John J., Han, Xianlin

“…Peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), a key regulator of energy metabolism and lipid homeostasis in multiple highly…”
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PGC-1α and ERRα target gene downregulation is a signature of the failing human heart by Sihag, Smita, Cresci, Sharon, Li, Allie Y, Sucharov, Carmen C, Lehman, John J

“…Abstract Heart failure is a cause of significant morbidity and mortality in developed nations, and results from a complex interplay between genetic and…”
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A Role for the Transcriptional Coactivator PGC-1α in Muscle Refueling by Wende, Adam R., Schaeffer, Paul J., Parker, Glendon J., Zechner, Christoph, Han, Dong-Ho, Chen, May M., Hancock, Chad R., Lehman, John J., Huss, Janice M., McClain, Donald A., Holloszy, John O., Kelly, Daniel P.

“…The transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) has been identified as an inducible regulator of…”
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PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis by Leone, Teresa C, Lehman, John J, Finck, Brian N, Schaeffer, Paul J, Wende, Adam R, Boudina, Sihem, Courtois, Michael, Wozniak, David F, Sambandam, Nandakumar, Bernal-Mizrachi, Carlos, Chen, Zhouji, O. Holloszy, John, Medeiros, Denis M, Schmidt, Robert E, Saffitz, Jeffrey E, Abel, E. Dale, Semenkovich, Clay F, Kelly, Daniel P

“…The gene encoding the transcriptional coactivator peroxisome proliferator- activated receptor- coactivator-1 alpha (PGC-1 alpha ) was targeted in mice. PGC-1…”
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Cardiac-Specific Induction of the Transcriptional Coactivator Peroxisome Proliferator-Activated Receptor γ Coactivator-1α Promotes Mitochondrial Biogenesis and Reversible Cardiomyopathy in a Developmental Stage-Dependent Manner by Russell, Laurie K, Mansfield, Carolyn M, Lehman, John J, Kovacs, Attila, Courtois, Michael, Saffitz, Jeffrey E, Medeiros, Denis M, Valencik, Maria L, McDonald, John A, Kelly, Daniel P

“…ABSTRACT—Recent evidence has identified the peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) as a regulator of cardiac energy metabolism…”
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Restoration of Insulin-Sensitive Glucose Transporter (GLUT4) Gene Expression in Muscle Cells by the Transcriptional Coactivator PGC-1 by Michael, Laura F., Wu, Zhidan, Cheatham, R. Bentley, Puigserver, Pere, Adelmant, Guillaume, Lehman, John J., Kelly, Daniel P., Spiegelman, Bruce M.

“…Muscle tissue is the major site for insulin-stimulated glucose uptake in vivo, due primarily to the recruitment of the insulin-sensitive glucose transporter…”
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Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth by Lehman, John J, Kelly, Daniel P

“…Studies in a variety of mammalian species, including humans, have demonstrated a reduction in fatty acid oxidation (FAO) and increased glucose utilization in…”
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The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus by Finck, Brian N., Lehman, John J., Leone, Teresa C., Welch, Michael J., Bennett, Michael J., Kovacs, Attila, Han, Xianlin, Gross, Richard W., Kozak, Ray, Lopaschuk, Gary D., Kelly, Daniel P.

“…Recent evidence has defined an important role for PPAR alpha in the transcriptional control of cardiac energy metabolism. To investigate the role of PPAR alpha…”
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Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis by Lehman, J J, Barger, P M, Kovacs, A, Saffitz, J E, Medeiros, D M, Kelly, D P

“…Cardiac mitochondrial function is altered in a variety of inherited and acquired cardiovascular diseases. Recent studies have identified the transcriptional…”
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The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis by Lehman, John J, Boudina, Sihem, Banke, Natasha Hausler, Sambandam, Nandakumar, Han, Xianlin, Young, Deanna M, Leone, Teresa C, Gross, Richard W, Lewandowski, E Douglas, Abel, E Dale, Kelly, Daniel P

“…High-capacity mitochondrial ATP production is essential for normal function of the adult heart, and evidence is emerging that mitochondrial derangements occur…”
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A Role for the Transcriptional Coactivator PGC-1α in Muscle Refueling by Adam R. Wende, Paul J. Schaeffer, Glendon J. Parker, Christoph Zechner, Dong-Ho Han, May M. Chen, Chad R. Hancock, John J. Lehman, Janice M. Huss, Donald A. McClain, John O. Holloszy, Daniel P. Kelly

“…The transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) has been identified as an inducible regulator of…”
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A role for the transcriptional coactivator PGC-1alpha in muscle refueling by Wende, Adam R, Schaeffer, Paul J, Parker, Glendon J, Zechner, Christoph, Han, Dong-Ho, Chen, May M, Hancock, Chad R, Lehman, John J, Huss, Janice M, McClain, Donald A, Holloszy, John O, Kelly, Daniel P

“…The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) has been identified as an inducible regulator…”
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Dramatic Accumulation of Triglycerides and Precipitation of Cardiac Hemodynamic Dysfunction during Brief Caloric Restriction in Transgenic Myocardium Expressing Human Calcium-independent Phospholipase A2γ by Mancuso, David J., Han, Xianlin, Jenkins, Christopher M., Lehman, John J., Sambandam, Nandakumar, Sims, Harold F., Yang, Jingyue, Yan, Wei, Yang, Kui, Green, Karen, Abendschein, Dana R., Saffitz, Jeffrey E., Gross, Richard W.

“…Previously, we identified calcium-independent phospholipase A2γ (iPLA2γ) with multiple translation initiation sites and dual mitochondrial and peroxisomal…”
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Dramatic Accumulation of Triglycerides and Precipitation of Cardiac Hemodynamic Dysfunction during Brief Caloric Restriction in Transgenic Myocardium Expressing Human Calcium-independent Phospholipase A2Î by David J. Mancuso, Xianlin Han, Christopher M. Jenkins, John J. Lehman, Nandakumar Sambandam, Harold F. Sims, Jingyue Yang, Wei Yan, Kui Yang, Karen Green, Dana R. Abendschein, Jeffrey E. Saffitz, Richard W. Gross

“…Previously, we identified calcium-independent phospholipase A 2 γ (iPLA 2 γ) with multiple translation initiation sites and dual mitochondrial and…”
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Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma by Mancuso, David J, Han, Xianlin, Jenkins, Christopher M, Lehman, John J, Sambandam, Nandakumar, Sims, Harold F, Yang, Jingyue, Yan, Wei, Yang, Kui, Green, Karen, Abendschein, Dana R, Saffitz, Jeffrey E, Gross, Richard W

“…Previously, we identified calcium-independent phospholipase A2gamma (iPLA2gamma) with multiple translation initiation sites and dual mitochondrial and…”
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Dramatic Accumulation of Triglycerides and Precipitation of Cardiac Hemodynamic Dysfunction during Brief Caloric Restriction in Transgenic Myocardium Expressing Human Calcium-independent Phospholipase A sub(2) gamma by Mancuso, David J, Han, Xianlin, Jenkins, Christopher M, Lehman, John J, Sambandam, Nandakumar, Sims, Harold F, Yang, Jingyue, Yan, Wei, Yang, Kui, Green, Karen, Abendschein, Dana R, Saffitz, Jeffrey E, Gross, Richard W

“…Previously, we identified calcium-independent phospholipase A sub(2) gamma (iPLA sub(2) gamma ) with multiple translation initiation sites and dual…”
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Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth : Myocardial energy metabolism in heart failure by LEHMAN, John J, KELLY, Daniel P

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PGC-1alpha and ERRalpha target gene downregulation is a signature of the failing human heart by Sihag, Smita, Cresci, Sharon, Li, Allie Y, Sucharov, Carmen C, Lehman, John J

“…Heart failure is a cause of significant morbidity and mortality in developed nations, and results from a complex interplay between genetic and environmental…”
Get full text