Search Results - "Lehenkari, Petri"

Automatic Knee Osteoarthritis Diagnosis from Plain Radiographs: A Deep Learning-Based Approach by Tiulpin, Aleksei, Thevenot, Jérôme, Rahtu, Esa, Lehenkari, Petri, Saarakkala, Simo

“…Knee osteoarthritis (OA) is the most common musculoskeletal disorder. OA diagnosis is currently conducted by assessing symptoms and evaluating plain…”
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Effect of bioactive extruded PLA/HA composite films on focal adhesion formation of preosteoblastic cells by Persson, Maria, Lorite, Gabriela S., Kokkonen, Hanna E., Cho, Sung-Woo, Lehenkari, Petri P., Skrifvars, Mikael, Tuukkanen, Juha

“…•Bioactive PLA/HA composite films were done via melt extrusion.•HA particles enhanced protein adsorption as well as attachment of MC3T3-cells.•HA particles…”
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Osteogenic Differentiation of Human Mesenchymal Stem cells in a 3D Woven Scaffold by Persson, Maria, Lehenkari, Petri P., Berglin, Lena, Turunen, Sanna, Finnilä, Mikko A. J., Risteli, Juha, Skrifvars, Mikael, Tuukkanen, Juha

“…Fiber-based scaffolds produced by textile manufacturing technology offer versatile materials for tissue engineering applications since a wide range of crucial…”
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Subchondral bone histology and grading in osteoarthritis by Aho, Olli-Matti, Finnilä, Mikko, Thevenot, Jerome, Saarakkala, Simo, Lehenkari, Petri

“…Osteoarthritis (OA) has often regarded as a disease of articular cartilage only. New evidence has shifted the paradigm towards a system biology approach, where…”
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A single intra-articular dose of vitamin D analog calcipotriol alleviates synovitis without adverse effects in rats by Huhtakangas, Johanna A, Huovinen, Jere, Laaksonen, Sakari, Voipio, Hanna-Marja, Vuolteenaho, Olli, Finnilä, Mikko A J, Thevenot, Jérôme, Lehenkari, Petri P

“…1,25-dihydroxyvitamin-D3 and its derivatives have shown anti-arthritic and chondroprotective effects in experimental animal models with prophylactic dosing…”
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Osteoclastogenesis of human peripheral blood, bone marrow, and cord blood monocytes by Vuoti, Ella, Lehenkari, Petri, Tuukkanen, Juha, Glumoff, Virpi, Kylmäoja, Elina

“…Osteoclasts are multinucleated bone resorbing cells that can be differentiated from human monocytes in vitro. There are few studies comparing…”
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Histochemical quantification of collagen content in articular cartilage by Rieppo, Lassi, Janssen, Lauriane, Rahunen, Krista, Lehenkari, Petri, Finnilä, Mikko A J, Saarakkala, Simo

“…Articular cartilage (AC) is mainly composed of water, type II collagen, proteoglycans (PGs) and chondrocytes. The amount of PGs in AC is routinely quantified…”
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Association between subchondral bone structure and osteoarthritis histopathological grade by Finnilä, Mikko A. J., Thevenot, Jérôme, Aho, Olli‐Matti, Tiitu, Virpi, Rautiainen, Jari, Kauppinen, Sami, Nieminen, Miika T., Pritzker, Kenneth, Valkealahti, Maarit, Lehenkari, Petri, Saarakkala, Simo

“…ABSTRACT Despite increasing evidence that subchondral bone contributes to osteoarthritis (OA) pathogenesis, little is known about local changes in bone…”
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Mesenchymal Stromal Cells and Their Extracellular Vesicles Enhance the Anti-Inflammatory Phenotype of Regulatory Macrophages by Downregulating the Production of Interleukin (IL)-23 and IL-22 by Hyvärinen, Kati, Holopainen, Minna, Skirdenko, Vita, Ruhanen, Hanna, Lehenkari, Petri, Korhonen, Matti, Käkelä, Reijo, Laitinen, Saara, Kerkelä, Erja

“…Resolution-phase macrophage population orchestrates active dampening of the inflammation by secreting anti-inflammatory and proresolving products including…”
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Distinct fatty acid signatures in infrapatellar fat pad and synovial fluid of patients with osteoarthritis versus rheumatoid arthritis by Mustonen, Anne-Mari, Käkelä, Reijo, Lehenkari, Petri, Huhtakangas, Johanna, Turunen, Sanna, Joukainen, Antti, Kääriäinen, Tommi, Paakkonen, Tommi, Kröger, Heikki, Nieminen, Petteri

“…Infrapatellar fat pad (IFP) has recently emerged as a potential source of inflammation in knee arthropathies. It has been proposed to be one source of…”
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Cigarette smoke and nicotine effect on human mesenchymal stromal cell wound healing and osteogenic differentiation capacity by Heikkinen, Janne, Tanner, Tarja, Bergmann, Ulrich, Palosaari, Sanna, Lehenkari, Petri

“…Mesenchymal stromal cells (MSCs) play a crucial role in promoting tissue regeneration and healing, particularly in bone tissue. Both smoking and nicotine use…”
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Toll-like receptors 1, 2, 4 and 6 in esophageal epithelium, Barrett's esophagus, dysplasia and adenocarcinoma by Huhta, Heikki, Helminen, Olli, Lehenkari, Petri P, Saarnio, Juha, Karttunen, Tuomo J, Kauppila, Joonas H

“…Toll-like receptors (TLRs) recognize microbial and endogenous ligands and have already shown to play a role in esophageal cancer. In this study, we evaluated…”
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Tenascin C, Fibronectin, and Tumor-Stroma Ratio in Pancreatic Ductal Adenocarcinoma by Leppänen, Joni, Lindholm, Ville, Isohookana, Joel, Haapasaari, Kirsi-Maria, Karihtala, Peeter, Lehenkari, Petri P, Saarnio, Juha, Kauppila, Joonas H, Karttunen, Tuomo J, Helminen, Olli, Huhta, Heikki

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma with increased expression of tenascin C and fibronectin. Their role and…”
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Preliminary Report: Osteoarthritis and Rheumatoid Arthritis Synovial Fluid Increased Osteoclastogenesis In Vitro by Monocyte Differentiation Pathway Regulating Cytokines by Luukkonen, Jani, Huhtakangas, Johanna, Palosaari, Sanna, Tuukkanen, Juha, Vuolteenaho, Olli, Lehenkari, Petri

“…Background. Rheumatoid arthritis (RA) and osteoarthritis (OA) are common joint diseases associated with changes in local, as well as systemic bone structure…”
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The Expression of Toll-like Receptors in Normal Human and Murine Gastrointestinal Organs and the Effect of Microbiome and Cancer by Huhta, Heikki, Helminen, Olli, Kauppila, Joonas H., Salo, Tuula, Porvari, Katja, Saarnio, Juha, Lehenkari, Petri P., Karttunen, Tuomo J.

“…Toll-like receptors (TLRs) are innate immune receptors expressed in all parts of the alimentary tract. However, analyses comparing expression in different…”
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Cell Surface Structures Influence Lung Clearance Rate of Systemically Infused Mesenchymal Stromal Cells by Nystedt, Johanna, Anderson, Heidi, Tikkanen, Jonne, Pietilä, Mika, Hirvonen, Tia, Takalo, Reijo, Heiskanen, Annamari, Satomaa, Tero, Natunen, Suvi, Lehtonen, Siri, Hakkarainen, Tanja, Korhonen, Matti, Laitinen, Saara, Valmu, Leena, Lehenkari, Petri

“…The promising clinical effects of mesenchymal stromal/stem cells (MSCs) rely especially on paracrine and nonimmunogenic mechanisms. Delivery routes are…”
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Gravidity, parity and knee breadth at midlife: a population-based cohort study by Junno, Juho-Antti, Keisu, Asla, Niinimäki, Maarit, Niinimäki, Jaakko, Lehenkari, Petri, Oura, Petteri

“…Gestation increases the biomechanical loading of lower extremities. Gestational loading may influence anthropometrics of articular surfaces in similar means as…”
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Metabolism and phospholipid assembly of polyunsaturated fatty acids in human bone marrow mesenchymal stromal cells1 by Tigistu-Sahle, Feven, Lampinen, Milla, Kilpinen, Lotta, Holopainen, Minna, Lehenkari, Petri, Laitinen, Saara, Käkelä, Reijo

“…High arachidonic acid (20:4n-6) and low n-3 PUFA levels impair the capacity of cultured human bone marrow mesenchymal stromal cells (hBMSCs) to modulate immune…”
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Intratumoral lactate metabolism in Barrett's esophagus and adenocarcinoma by Huhta, Heikki, Helminen, Olli, Palomäki, Sami, Kauppila, Joonas H, Saarnio, Juha, Lehenkari, Petri P, Karttunen, Tuomo J

“…Monocarboxylate transporters (MCTs) are cell membrane proteins which transport pyruvate, lactate and ketone bodies across the plasma membrane. MCTs are…”
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Characterization of hyaluronan-coated extracellular vesicles in synovial fluid of patients with osteoarthritis and rheumatoid arthritis by Mustonen, Anne-Mari, Capra, Janne, Rilla, Kirsi, Lehenkari, Petri, Oikari, Sanna, Kääriäinen, Tommi, Joukainen, Antti, Kröger, Heikki, Paakkonen, Tommi, Matilainen, Johanna, Nieminen, Petteri

“…Hyaluronic acid (HA) is the major extracellular matrix glycosaminoglycan with a reduced synovial fluid (SF) concentration in arthropathies. Cell-derived…”
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