Search Results - "Leguto, Alcides J."

Electrochemical characterization of an engineered red copper protein featuring an unprecedented entropic control of the reduction potential by Szuster, Jonathan, Leguto, Alcides J., Zitare, Ulises A., Rebechi, Juan P., Vila, Alejandro J., Murgida, Daniel H.

“…•Ligand loop replacement of a CuA site leads to a T2-like mononuclear copper protein.•The T2 chimera is the first Cu site with entropically controlled redox…”
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CuA-based chimeric T1 copper sites allow for independent modulation of reorganization energy and reduction potential by Szuster, Jonathan, Zitare, Ulises A, Castro, María A, Leguto, Alcides J, Morgada, Marcos N, Vila, Alejandro J, Murgida, Daniel H

“…Attaining rational modulation of thermodynamic and kinetic redox parameters of metalloproteins is a key milestone towards the (re)design of proteins with new…”
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The role of molecular crowding in long-range metalloprotein electron transfer: Dissection into site- and scaffold-specific contributions by Zitare, Ulises A., Szuster, Jonathan, Scocozza, Magali F., Espinoza-Cara, Andrés, Leguto, Alcides J., Morgada, Marcos N., Vila, Alejandro J., Murgida, Daniel H.

“…Here we report the effect of molecular crowding on long-range protein electron transfer (ET) and disentangle the specific responses of the redox site and the…”
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Dramatic Electronic Perturbations of Cu A Centers via Subtle Geometric Changes by Leguto, Alcides J, Smith, Meghan A, Morgada, Marcos N, Zitare, Ulises A, Murgida, Daniel H, Lancaster, Kyle M, Vila, Alejandro J

“…Cu is a binuclear copper site acting as electron entry port in terminal heme-copper oxidases. In the oxidized form, Cu is a mixed valence pair whose electronic…”
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Tuning of Enthalpic/Entropic Parameters of a Protein Redox Center through Manipulation of the Electronic Partition Function by Alvarez-Paggi, Damian, Zitare, Ulises A, Szuster, Jonathan, Morgada, Marcos N, Leguto, Alcides J, Vila, Alejandro J, Murgida, Daniel H

“…Manipulation of the partition function (Q) of the redox center CuA from cytochrome c oxidase is attained by tuning the accessibility of a low lying alternative…”
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Dramatic Electronic Perturbations of CuA Centers via Subtle Geometric Changes by Leguto, Alcides J, Smith, Meghan A, Morgada, Marcos N, Zitare, Ulises A, Murgida, Daniel H, Lancaster, Kyle M, Vila, Alejandro J

“…CuA is a binuclear copper site acting as electron entry port in terminal heme-copper oxidases. In the oxidized form, CuA is a mixed valence pair whose…”
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Cu-based chimeric T1 copper sites allow for independent modulation of reorganization energy and reduction potential by Szuster, Jonathan, Zitare, Ulises A, Castro, María A, Leguto, Alcides J, Morgada, Marcos N, Vila, Alejandro J, Murgida, Daniel H

“…Attaining rational modulation of thermodynamic and kinetic redox parameters of metalloproteins is a key milestone towards the (re)design of proteins with new…”
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Evolution of erythrocytes aggregation: A fractal approach when incubated with Trichinella spiralis and Ascaris lumbricoides by Maela Lupo, Alcides J. Leguto, Santiago A. Bortolato, Ana M. Korol

“…Fractal geometry has provided a new range of concepts that could explain the non-linear behaviour of seemingly unpredictable natural systems. The aim of this…”
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CuA-based chimeric T1 copper sites allow for independent modulation of reorganization energy and reduction potential† †Electronic supplementary information (ESI) available: Resonance Raman spectra, electrochemical data and computational (MDS and QM/MM) results. See DOI: 10.1039/d0sc01620a by Szuster, Jonathan, Zitare, Ulises A., Castro, María A., Leguto, Alcides J., Morgada, Marcos N., Vila, Alejandro J., Murgida, Daniel H.

“…Attaining rational modulation of thermodynamic and kinetic redox parameters of metalloproteins is a key milestone towards the (re)design of proteins with new…”
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New insights into the analysis of red blood cells from leukemia and anemia patients: Nonlinear quantifiers, fractal mathematics, and Wavelet Transform by Bortolato, Santiago A., Mancilla Canales, Manuel A., Riquelme, Bibiana D., Raviola, Mariana, Leguto, Alcides J., Rebechi, Juan P., Ponce de León, Patricia, Korol, Ana M.

“…The alterations of red blood cells (RBCs) membrane in many hematological diseases prevent blood to accomplish its functions, but how these alterations occur is…”
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Study of the erythrocyte aggregation produced by Ascaris lumbricoides using the May-Sugihara method by Mancilla Canales, Manuel A., Riquelme, Bibiana D., Korol, Ana M., de Leon, Patricia Ponce, Leguto, Alcides J., Bortolato, Santiago A.

“…Natural systems are characterized by seemingly unpredictable behaviors. For their study, new mathematical tools are required to adequately measure the…”
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