Search Results - "Legrini, Assya"
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High-plex proteomic prognostic marker discovery for patients with pancreatic cancer adenocarcinoma using digital spatial profiling
Published in Journal of clinical oncology (01-02-2022)“…Abstract only 611 Background: The long-term outcomes following surgical resection for Pancreatic Ductal Adenocarcinoma (PDAC) remain poor, with only 20% of…”
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Effect of spatial transcriptomic-derived intrinsic epithelial signatures on immune cell recruitment and behaviour in the microenvironment of colorectal cancer
Published in Journal of clinical oncology (01-02-2023)“…251 Background: Colorectal Cancer (CRC) remains a significant healthcare problem. Interest in the role of the Tumour Microenvironment (TME) in progression and…”
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Spatially resolved transcriptomics deconvolutes histological prognostic subgroups in patients with colorectal cancer and synchronous liver metastases
Published in Journal of clinical oncology (01-02-2022)“…Abstract only 165 Background: Up to 50% of patients with Colorectal Cancer (CRC) will metastasise to the liver (CRLM). KRAS-mt liver metastases particularly…”
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Biological Misinterpretation of Transcriptional Signatures in Tumor Samples Can Unknowingly Undermine Mechanistic Understanding and Faithful Alignment with Preclinical Data
Published in Clinical cancer research (15-09-2022)“…Precise mechanism-based gene expression signatures (GES) have been developed in appropriate in vitro and in vivo model systems, to identify important…”
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Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases
Published in Cancer research (Chicago, Ill.) (14-04-2023)“…Strong immune responses in primary colorectal cancer correspond with better patient survival following surgery compared with tumors with predominantly stromal…”
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Abstract 2031: High plex proteomic prognostic marker discovery for patients with pancreatic adenocarcinoma using digital spatial profiling
Published in Cancer research (Chicago, Ill.) (15-06-2022)“…Abstract Pancreatic Ductal Adenocarcinoma (PDAC) long-term outcomes following surgical resection remain poor, with only 20% of patients surviving 5 years post…”
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Abstract A028: Multiomic modelling of pancreatic IPMN stroma reveals distinct tertiary lymphoid structure distribution: Mapping the transcriptomic landscape via regional bulk, single-cell and subcellular approaches
Published in Cancer research (Chicago, Ill.) (16-01-2024)“…Abstract Background Intraductal Papillary Mucinous Neoplasms (IPMN) remain the largest subtype of cystic pancreatic cancer precursors. Cancer risk has been…”
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Abstract 4691: Spatially resolved transcriptomics deconvolutes histological prognostic subgroups in patients with colorectal cancer and synchronous liver metastases
Published in Cancer research (Chicago, Ill.) (04-04-2023)“…Abstract Patients demonstrating strong immune responses to primary colorectal cancer (CRC) have a survival benefit following surgery, while those with…”
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Abstract 5072: Multi-omic, multi-scale characterisation of colorectal cancer defines spatiotemporal patterns of recurrence
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Abstract Aim: Patients who undergo intended curative resection of colorectal cancer (CRC) have a 20-25% chance of metachronous recurrence, the site and timing…”
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JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors
Published in Journal of experimental & clinical cancer research (01-03-2024)“…Colorectal cancer (CRC) is a heterogenous malignancy underpinned by dysregulation of cellular signaling pathways. Previous literature has implicated aberrant…”
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Vascular mechanisms of post-COVID-19 conditions: Rho-kinase is a novel target for therapy
Published in European heart journal. Cardiovascular pharmacotherapy (02-06-2023)“…Abstract Background In post-coronavirus disease-19 (post-COVID-19) conditions (long COVID), systemic vascular dysfunction is implicated, but the mechanisms are…”
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