Search Results - "Legrier, Marie‐Emmanuelle"

Targeting Protein Translation in Human Non-Small Cell Lung Cancer via Combined MEK and Mammalian Target of Rapamycin Suppression by LEGRIER, Marie-Emmanuelle, YANG, Chia-Ping Huang, YAN, Han-Guang, LOPEZ-BARCONS, Lluis, KELLER, Steven M, PEREZ-SOLER, Roman, BAND HORWITZ, Susan, MCDAID, Hayley M

“…Lung cancer is a genetically heterogeneous disease characterized by the acquisition of somatic mutations in numerous protein kinases, including components of…”
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Genetic alterations associated with acquired temozolomide resistance in SNB-19, a human glioma cell line by Auger, Nathalie, Thillet, Joëlle, Wanherdrick, Krystell, Idbaih, Ahmed, Legrier, Marie-Emmanuelle, Dutrillaux, Bernard, Sanson, Marc, Poupon, Marie-France

“…Gliomas are highly lethal neoplasms that cannot be cured by currently available therapies. Temozolomide is a recently introduced alkylating agent that has…”
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Circulating HPV DNA as a Marker for Early Detection of Relapse in Patients with Cervical Cancer by Jeannot, Emmanuelle, Latouche, Aurélien, Bonneau, Claire, Calméjane, Marie-Ange, Beaufort, Corine, Ruigrok-Ritstier, Kirsten, Bataillon, Guillaume, Larbi Chérif, Linda, Dupain, Célia, Lecerf, Charlotte, Popovic, Marina, de la Rochefordière, Anne, Lecuru, Fabrice, Fourchotte, Virginie, Jordanova, Ekaterina S, von der Leyen, Heiko, Tran-Perennou, Carine, Legrier, Marie-Emmanuelle, Dureau, Sylvain, Raizonville, Laurence, Bello Roufai, Diana, Le Tourneau, Christophe, Bièche, Ivan, Rouzier, Roman, Berns, Els M J J, Kamal, Maud, Scholl, Suzy

“…Almost all cervical cancers are caused by human papillomavirus (HPV) and patients with advanced stage are at high risk for relapse. Circulating HPV DNA (HPV…”
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Activation of IFN/STAT1 signalling predicts response to chemotherapy in oestrogen receptor-negative breast cancer by Legrier, Marie-Emmanuelle, Bièche, Ivan, Gaston, Julie, Beurdeley, Arnaud, Yvonnet, Vanessa, Déas, Olivier, Thuleau, Aurélie, Château-Joubert, Sophie, Servely, Jean-Luc, Vacher, Sophie, Lassalle, Myriam, Depil, Stéphane, C Tucker, Gordon, Fontaine, Jean-Jacques, Poupon, Marie-France, Roman-Roman, Sergio, Judde, Jean-Gabriel, Decaudin, Didier, Cairo, Stefano, Marangoni, Elisabetta

“…Background: Oestrogen receptor-negative (ER−) breast cancer is intrinsically sensitive to chemotherapy. However, tumour response is often incomplete, and…”
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Clinical and Experimental Progression of a New Model of Human Prostate Cancer and Therapeutic Approach by de Pinieux, Gonzague, Legrier, Marie-Emmanuelle, Poirson-Bichat, Florence, Courty, Yves, Bras-Gonçalves, Rui, Dutrillaux, Anne-Marie, Némati, Fariba, Oudard, Stéphane, Lidereau, Rosette, Broqua, Pierre, Junien, Jean-Louis, Dutrillaux, Bernard, Poupon, Marie-France

“…We report the clinical evolution of a prostate cancer, metastasizing to lungs and bones, recurring locally, and escaping from anti-androgen therapy. Key event…”
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Clinical relevance of human cancer xenografts as a tool for preclinical assessment: example of in-vivo evaluation of topotecan-based chemotherapy in a panel of human small-cell lung cancer xenografts by Némati, Fariba, Daniel, Catherine, Arvelo, Francisco, Legrier, Marie-Emmanuelle, Froget, Benoît, Livartowski, Alain, Assayag, Franck, Bourgeois, Yveline, Poupon, Marie-France, Decaudin, Didier

“…Prediction of human tumor response based on preclinical data could reduce the failure rates of subsequent new anticancer drugs clinical development. Human…”
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Hormone escape is associated with genomic instability in a human prostate cancer model by Legrier, Marie‐Emmanuelle, Guyader, Charlotte, Céraline, Jocelyn, Dutrillaux, Bernard, Oudard, Stéphane, Poupon, Marie‐France, Auger, Nathalie

“…Lack of hormone dependency in prostate cancers is an irreversible event that occurs through generation of genomic instability induced by androgen deprivation…”
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Activity of docetaxel with or without estramustine phosphate versus mitoxantrone in androgen dependent and independent human prostate cancer xenografts by Oudard, Stephane, Legrier, Marie-Emmanuelle, Boyé, Karine, Bras-Gonçalves, Rui, De Pinieux, Gozague, De Cremoux, Patricia, Poupon, Marie-France

“…Prostate cancer is known to be refractory to chemotherapy with only mitoxantrone showing some benefit. Recent clinical data indicate the antitumoral efficacy…”
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Region-specific expression of cell cycle inhibitors in the adult brain by Legrier, Marie-Emmanuelle, Ducray, Angélique, Propper, Alain, Kastner, Anne

“…In the adult brain, neural proliferation is almost absent and neurons are generally not renewed. By contrast, in the olfactory organ, olfactory neurons are…”
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Abstract 2138: Functional evaluation of interferonSTAT1 pathway activation in response to genotoxic treatment by Gaston, Julie, Cheradame, Laura, Legrier, Marie-Emmanuelle, Deas, Olivier, Judde, Jean Gabriel, Goffin, Vincent, Cairo, Stefano

“…Triple negative breast cancer (TNBC) accounts for approximately 15-25 of breast cancers at diagnosis, and is one of the most aggressive subtypes, with around…”
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Abstract 2138: Functional evaluation of interferon/STAT1 pathway activation in response to genotoxic treatment by Gaston, Julie, Cheradame, Laura, Legrier, Marie-Emmanuelle, Deas, Olivier, Judde, Jean Gabriel, Goffin, Vincent, Cairo, Stefano

“…Abstract Triple negative breast cancer (TNBC) accounts for approximately 15-25% of breast cancers at diagnosis, and is one of the most aggressive subtypes,…”
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Abstract CT140: Circulating tumor cells as a tool to guide first line therapy in metastatic breast cancer: subgroup analyses of the STIC CTC Phase III utility trial by Bidard, Francois-Clement, Jacot, William, Dureau, Sylvain, Brain, Etienne, Bachelot, Thomas, Bourgeois, Hugues, Goncalves, Anthony, Ladoire, Sylvain, Naman, Herve, Dalenc, Florence, Gligorov, Joseph, Espie, Marc, Levy, Christelle, Ferrero, Jean-Marc, Loirat, Delphine, Cottu, Paul, Dieras, Veronique, Legrier, Marie-Emmanuelle, Berger, Frederique, Alix-Panabieres, Catherine, Pierga, Jean-Yves

“…Abstract Background: Endocrine therapy (ET) is the preferred 1st line therapy in ER+ HER2- metastatic breast cancer (MBC) patients, but not all benefit from…”
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HPV ctDNA detection of high-risk HPV types during chemoradiotherapy for locally advanced cervical cancer by Cabel, L., Bonneau, C., Bernard-Tessier, A., Héquet, D., Tran-Perennou, C., Bataillon, G., Rouzier, R., Féron, J.-G., Fourchotte, V., Le Brun, J.-F., Benoît, C., Rodrigues, M., Scher, N., Minsat, M., Legrier, M.-E., Bièche, I., Proudhon, C., Sastre-Garau, X., Bidard, F.-C., Jeannot, E.

“…Chemoradiotherapy (CRT) is the standard of care for patients diagnosed with locally advanced cervical cancer (LACC), a human papillomavirus (HPV)-related…”
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Abstract A103: Cell-autonomous activation of the interferon/STAT1 pathway in response to genotoxic treatment by Gaston, Julie, Cheradame, Laura, Legrier, Marie-Emmanuelle, Déas, Olivier, Lassalle, Myriam, Le Ven, Enora, Judde, Jean-Gabriel, Goffin, Vincent, Cairo, Stefano

“…Abstract Identification of the mechanisms of tumor resistance remains an unmet need in oncology. Among the reasons for this challenging issue is the lack of…”
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Abstract 5472: Loss of TSC2 function predicts optimal therapeutic response to combinations of MEK and mTOR inhibitors by Conlon, Beth A., Legrier, Marie-Emmanuelle, Rodriguez Gabin, Alicia G., Horwitz, Susan Band, McDaid, Hayley M.

“…Abstract The MAPK-RAS-PI3K signaling network is oncogenic in many human malignancies. The plasticity of cancer cell ‘circuitry’ is an important consideration…”
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Evaluation of the response to cabazitaxel of a docetaxel-responsive hormone-refractory prostate tumor xenograft model (HID28) by Bourre, Ludovic, Nicolle, Delphine, Legrier, Marie-Emmanuelle, Yvonnet, Vanessa, Charpentier, Julie, Poupon, Marie-France, Vrignaud, Patricia, Geffriaud-Ricouard, Christine, Oudard, Stephane, Judde, Jean-Gabriel

“…Abstract only e15161 Background: Docetaxel was the first cytotoxic treatment demonstrating a survival benefit in metastatic castration-resistant prostate…”
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Abstract 4423: Molecular characterization of cell foci that escape chemotherapy in relapsing models of human breast tumorgraft by Legrier, Marie-Emmanuelle, Beurdeley, Arnaud, Deas, Olivier, Lassalle, Myriam, Poupon, Marie-France, Cairo, Stefano, Judde, Jean-Gabriel

“…Abstract Despite great efforts in the field during the last decade, the genetic basis of cancer progression remains unknown. Most of treatments currently…”
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Cell cycle regulation during mouse olfactory neurogenesis by LEGRIER, Marie-Emmanuelle, DUCRAY, Angélique, PROPPER, Alain, CHAO, Moses, KASTNER, Anne

“…The development of the nervous system requires a strict control of cell cycle entry and withdrawal. The olfactory epithelium (OE) is noticeable by its ability…”
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Abstract 5273: XenTech patient-derived xenograft (PDX) panels: a clinically relevant platform for drug efficacy, target validation and predictive biomarker discovery studies by Cairo, Stefano, Déas, Olivier, Legrier-Rahali, Marie-Emmanuelle, Beurdeley, Arnaud, Stephant, Gaël, Poupon, Marie-France, Judde, Jean-Gabriel

“…Abstract Despite considerable efforts in understanding the biology and genetics of cancer, most currently available treatments fail to achieve tumor…”
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