Search Results - "Legon'kova, L F"

Correction of biotransformation of xenobiotics by α-tocopherol in combination with nicotinamide and methionine in the liver damaged by ultrasound by Zverinskii, I. V., Bushma, M. I., Legon’kova, L. F., Lukienko, P. I., Eismont, K. A.

“…Six day after rat liver sonication, the content of cytochrome P-450, rate of NADPH oxidation, activity of NADPH—cytochrome P-450 reductase, and rate of aniline…”
Get full text

Dysfunction and correction of microsomal enzyme oxidation, glucuronidation and glutathione conjugation of xenobiotics in the liver of deoxycholate-intoxicated rats by Bushma, M. I., Legon'kova, L. F., Zverinskii, I. V., Vasil'ev, A. V.

“…Intoxication with deoxycholic acid is accompanied by destruction of hepatocyte plasma membrane (increased serum alanine aminotransferase activity) and…”
Get full text

Correction of dysfunction of enzyme systems of microsomal oxidation, glucuronidation, and glutathione conjugation of xenobiotics in the liver of rats with deoxycholate intoxication by Bushma, M. I., Legon'kova, L. F., Zverinskii, I. V., Vasil'ev, A. V.

“…Intoxication with deoxycholic acid disturbed the integrity of hepatocyte plasma membranes (elevation of alanine transaminase activity in the plasma) and…”
Get full text

Inhibition and regulation of antioxidant protection, microsomal oxidation, and xenobiotic glucuronidation in cholestatic rats by Bushma, M. I., Legon'kova, L. F., Zverinskii, I. V., Khomich, T. I., Karpovich, V. E., Konovalenko, O. V., Karaedova, L. M., Lashak, L. K.

“…An 8-day biliary obstruction in rats caused by ligation of the common bile duct is accompanied by an increase in bilirubin blood content and alanine…”
Get full text

Inhibition of enzymes of drug metabolism in rat liver by ultrasound and correction by heparin by Legonkova, L.F., Bushma, M.I., Zverinsky, I.V., Eismont, K.A.

“…After 6 days following the local effect (during operation) of ultrasound (2 Wt/cm 2, 1 min) the microsomal fraction showed decreased total content of…”
Get full text

Effect of nicotinamide on lipid peroxidation by Abakumov, G Z, Bushma, M I, Lukienko, P I, Legon'kova, L F, Shurinov, A S

“…Nicotinamide (10-100 mM) caused a decrease in total "fast" flash of chemoluminescence, in rates of NADPH- and ascorbate dependent lipid peroxidation in…”
Get more information

The role of liver antioxidant system in predisposition of rats to hepatotoxic effect of ethanol by Bushma, M I, Zimatkin, S M, Ambrushkevich, IuG, Legon'kova, L F, Karaedova, L M, Bushma, T V, Khomich, T I, Sheĭbak, V M

“…A new methodological approach capable of revealing factors responsible for the susceptibility of rat liver to ethanol hepatotoxicity has been developed. Using…”
Get more information

Disturbed functioning of enzyme systems of microsomal oxidation, glucuro-, and glutathione conjugation of xenobiotics in the liver of rats intoxicated by deoxycholate and their correction by Bushma, M I, Legon'kova, L F, Zverinskiĭ, I V, Vasil'ev, A V

Get more information

Disturbed functioning of enzyme systems of the microsomal oxidation, glucuro- and glutathione conjugation of xenobiotics in the liver of rats intoxicated by deoxycholate and their correction by Bushma, M I, Legon'kova, L F, Zverinskiĭ, I V, Vasil'ev, A V

Get more information

The effect of nicotinamide, methionine and alpha-tocopherol on the liver conjugating and mono-oxygenase systems and on lipid peroxidation in hepatosis-hepatitis in rats by Legon'kova, L F, Bushma, M I, Zverinskiĭ, I V, Abakumov, G Z, Zavodnik, L V

“…Four days after a single intragastric injection of CCl4 (5 mg/kg as a 50% oil solution) increased intensity of a chemoluminescence "quick flush" in the hepatic…”
Get more information

Correction with alpha-tocopherol in combination with nicotinamide and methionine of xenobiotics biotransformation during ultrasound-induced liver injury by Zverinskiĭ, I V, Bushma, M I, Legon'kova, L F, Lukienko, P I, Eĭsmont, K A

Get more information

The effect of heparin on the activity of the mono-oxygenase glucuronyl- and glutathione transferase systems in ultrasonic damage to the rat liver by Eĭsmont, K A, Bushma, M I, Mal'chik, S S, Bushma, T V, Legon'kova, L F, Zverinskiĭ, I V

“…Six days after local exposure of the rat liver (during operation) to ultrasound (2 W/cm2, 1 min), the cytochrome P-450 content in the microsomal fraction…”
Get more information

Inhibition of the antioxidant protection, microsomal oxidation, and xenobiotic glucuroconjugation in rats with cholestasis and their regulation by Bushma, M I, Legon'kova, L F, Zverinskiĭ, I V, Khomich, T I, Karpovich, V E, Konovalenko, O V, Karaedova, L M, Lashak, L K

Get more information

The action of Essentiale and its combination with cordiamine and vitamin E on the processes of xenobiotic biotransformation and lipid peroxidation and on liver structure in rats with cholestasis by Zverinskiĭ, I V, Karpovich, V E, Bushma, M I, Legon'kova, L F, Mel'nichenko, N G, Nechiporenko, L I, Nikitin, V S

“…Intensive regeneration of cholangia and cholangioles, fibrosis, microglobular cirrhosis, vacuolar and granular dystrophy, and necrosis of hepatocytes were…”
Get more information

Comparative study of the effect of nicotinamide and diethylnicotinamide on monooxygenase, and glucuronyl- and glutathione-conjugating systems of the liver by Legon'kova, L. F., Bushma, M. I., Lukienko, P. I.

Get full text

The protective action of a combination of essentiale with diethylnicotinamid on rat liver mono-oxygenases and glucuronyl- and glutathione transferases in a trichloromethane lesion by Bushma, M I, Legon'kova, L F, Zavodnik, L B, Zverinskiĭ, I V, Lukienko, P I

Get more information

A comparative study of the effects of nicotinamide and diethylnicotinamid on hepatic monooxygenase, glucuronyl and glutathione conjugating systems by Legon'kova, L F, Bushma, M I, Lukienko, P I

“…The nicotinamide administration to rats (50 mg/kg, subcutaneously, over 5 days) increased the concentration of liver cytochrome b5, the activities of cytosol…”
Get more information

The effect of folic acid and methotrexate on the activity of the glucuronyl- and glutathione-conjugating systems of the liver in rats by Legon'kova, L F, Lukienko, P I, Bushma, M I

“…Administration to intact male rats of folic acid (25 mg/kg intragastrically for 14 days) was shown to increase and that of methotrexate (0.5 mg/kg…”
Get more information

The role of lipid peroxidation in the pathogenesis of viral hepatitis by Abakumov, G Z, Novitskiĭ, G K, Legon'kova, L F

“…Content of blood bilirubin was increased 3.3-11.4-fold as well as 4-10-activation of alanine aminotransferase and glutathione S-transferase was found in…”
Get more information

Effect of nicotinic acid, nicotinamide and its combination with ziksorin and phenobarbital on the UDP glucuronyl transferase activity of the hepatic endoplasmic reticulum in the rat by Legon'kova, L F, Lukienko, P I, Bushma, M I

“…Nicotinic acid and nicotinamide (100 mg/kg) increase the activity of the rat liver microsomal uridine diphosphate-glucuronyltransferase by 55 and 73.8%…”
Get more information