Search Results - "Legmann, Rachel"

predictive high-throughput scale-down model of monoclonal antibody production in CHO cells by Legmann, Rachel, Schreyer, H. Brett, Combs, Rodney G, McCormick, Ellen L, Russo, A. Peter, Rodgers, Seth T

“…Multi-factorial experimentation is essential in understanding the link between mammalian cell culture conditions and the glycoprotein product of any…”
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A Strategy for clone selection under different production conditions by Legmann, Rachel, Benoit, Brian, Fedechko, Ronald W., Deppeler, Cynthia L., Srinivasan, Sriram, Robins, Russell H., McCormick, Ellen L., Ferrick, David A., Rodgers, Seth T., Russo, A. Peter

“…Top performing clones have failed at the manufacturing scale while the true best performer may have been rejected early in the screening process. Therefore,…”
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Analysis of glycolytic flux as a rapid screen to identify low lactate producing CHO cell lines with desirable monoclonal antibody yield and glycan profile by Legmann, Rachel, Melito, Julie, Belzer, Ilana, Ferrick, David

“…The lowest lactic acid and ECAR were obtained when galacose or fructose was present in the media during the glycoprotein production phase. [...] adding…”
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Antioxidant enhanced spare capacity in cardiomyocytes as a protective response to oxidative stress induced by hypoxia and redox cycling agent by Legmann, Rachel, melito, Julie, Ferrick, David

“…Increased reactive oxygen species (ROS) generation underlies many pathologies of the cardiovascular system. Strategies that enhance the cell's ability to cope…”
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Reversible Refolding of the Diphtheria Toxin T-Domain on Lipid Membranes by Ladokhin, Alexey S, Legmann, Rachel, Collier, R. John, White, Stephen H

“…The catalytic domain of diphtheria toxin (DT) is translocated across endosomal membranes by the T-domain (DTT) in response to acidification. Understanding the…”
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2001: a year of major advances in anthrax toxin research by Mourez, Michael, Lacy, D.Borden, Cunningham, Kristina, Legmann, Rachel, Sellman, Bret R, Mogridge, Jeremy, Collier, R.John

“…Anthrax is caused when spores of Bacillus anthracis enter a host and germinate. The bacteria multiply and secrete a tripartite toxin causing local edema and,…”
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Preclinical evaluation of group B streptococcal polysaccharide conjugate vaccines prepared with a modified diphtheria toxin and a recombinant duck hepatitis B core antigen by Paoletti, Lawrence C, Peterson, Darrell L, Legmann, Rachel, Collier, R.John

“…An effective vaccine against group B streptococcal (GBS) disease will undoubtedly include capsular polysaccharides (CPSs) from each of the five serotypes…”
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Petroleum bioremediation―a multiphase problem by ROSENBERG, E, LEGMANN, R, KUSHMARO, A, TAUBE, R, ADLER, E, RON, E. Z

“…Since petroleum is a complex mixture of many different classes of hydrocarbons, of which any particular microorganism has the potential to degrade only part,…”
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