Search Results - "Leggio, L"

Advances in the science and treatment of alcohol use disorder by Witkiewitz, K, Litten, R Z, Leggio, L

“…Alcohol is a major contributor to global disease and a leading cause of preventable death, causing approximately 88,000 deaths annually in the United States…”
Get full text

Oxytocin by intranasal and intravenous routes reaches the cerebrospinal fluid in rhesus macaques: determination using a novel oxytocin assay by Lee, M R, Scheidweiler, K B, Diao, X X, Akhlaghi, F, Cummins, A, Huestis, M A, Leggio, L, Averbeck, B B

“…Oxytocin (OT) is a potential treatment for multiple neuropsychiatric disorders. As OT is a peptide, delivery by the intranasal (IN) route is the preferred…”
Get full text

Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques by Lee, M. R., Shnitko, T. A., Blue, S. W., Kaucher, A. V., Winchell, A. J., Erikson, D. W., Grant, K. A., Leggio, L.

“…Oxytocin may have promise as a treatment for neuropsychiatric disorders. Its therapeutic effect may depend on its ability to enter the brain and bind to the…”
Get full text

Structural and electronic determinants of lytic polysaccharide monooxygenase reactivity on polysaccharide substrates by Simmons, T. J., Frandsen, K. E. H., Ciano, L., Tryfona, T., Lenfant, N., Poulsen, J. C., Wilson, L. F. L., Tandrup, T., Tovborg, M., Schnorr, K., Johansen, K. S., Henrissat, B., Walton, P. H., Lo Leggio, L, Dupree, P.

“…Lytic polysaccharide monooxygenases (LPMOs) are industrially important copper-dependent enzymes that oxidatively cleave polysaccharides. Here we present a…”
Get full text

Development and initial characterization of a novel ghrelin receptor CRISPR/Cas9 knockout wistar rat model by Zallar, L. J., Tunstall, B. J., Richie, C. T., Zhang, Y. J., You, Z. B., Gardner, E. L., Heilig, M., Pickel, J., Koob, G. F., Vendruscolo, L. F., Harvey, B. K., Leggio, L.

“…Background/objectives Ghrelin, a stomach-derived hormone implicated in numerous behaviors including feeding, reward, stress, and addictive behaviors, acts by…”
Get full text

Exogenous ghrelin administration increases alcohol self-administration and modulates brain functional activity in heavy-drinking alcohol-dependent individuals by Farokhnia, M, Grodin, E N, Lee, M R, Oot, E N, Blackburn, A N, Stangl, B L, Schwandt, M L, Farinelli, L A, Momenan, R, Ramchandani, V A, Leggio, L

“…Preclinical evidence suggests that ghrelin, a peptide synthesized by endocrine cells of the stomach and a key component of the gut–brain axis, is involved in…”
Get full text

Oxytocin receptor mRNA expression in dorsolateral prefrontal cortex in major psychiatric disorders: A human post-mortem study by Lee, M.R., Sheskier, M.B., Farokhnia, M., Feng, N., Marenco, S., Lipska, B.K., Leggio, L.

“…•Brain expression of oxytocin and its receptor genes in patients with major psychiatric disorders has not been well studied outside the hypothalamus.•We…”
Get full text

Understanding plasma treatment effect on human acyl-ghrelin concentrations by Deschaine, S L, Leggio, L

“…We evaluated the effect of different concentrations of the esterase inhibitor, AEBSF, and acid treatment on acyl-ghrelin stability in human plasma samples…”
Get more information

S.15.04 Role of baclofen and modulation at GABAB receptor in treating addiction: a clinical prospective by Leggio, L

Get full text

Baclofen for the Treatment of Alcohol Dependence and Possible Role of Comorbid Anxiety by MORLEY, K. C, BAILLIE, A, LEUNG, S, ADDOLORATO, G, LEGGIO, L, HABER, P. S

“…To conduct a double-blind, placebo-controlled randomized clinical trial of baclofen in the treatment of alcohol dependence. Out of 69 participants…”
Get full text

Spironolactone in Alcohol Use Disorder (SAUD): Introduction to an ongoing double-blind, placebo-controlled, ascending dose, Phase 1b study by Leko, A, Farokhnia, M, Weiss, S T, Blake, C A, Farinelli, L A, Leggio, L

“…IntroductionEfforts are critically needed to increase the armamentarium of options that clinicians can use to treat patients with alcohol use disorder (AUD)…”
Get full text

Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study by Addolorato, Giovanni, Dr, Leggio, Lorenzo, MD, Ferrulli, Anna, MD, Cardone, Silvia, MD, Vonghia, Luisa, MD, Mirijello, Antonio, MD, Abenavoli, Ludovico, MD, D'Angelo, Cristina, MD, Caputo, Fabio, MD, Zambon, Antonella, PhD, Haber, Paul S, Prof, Gasbarrini, Giovanni, Prof

“…Summary Background Intervention to achieve alcohol abstinence represents the most effective treatment for alcohol-dependent patients with liver cirrhosis;…”
Get full text

S.08.04 Relationship between ghrelin and alcohol craving and intake: recent clinical findings by Leggio, L

Get full text

A relationship between the aldosterone–mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans by Aoun, E G, Jimenez, V A, Vendruscolo, L F, Walter, N A R, Barbier, E, Ferrulli, A, Haass-Koffler, C L, Darakjian, P, Lee, M R, Addolorato, G, Heilig, M, Hitzemann, R, Koob, G F, Grant, K A, Leggio, L

“…Aldosterone regulates electrolyte and fluid homeostasis through binding to the mineralocorticoid receptors (MRs). Previous work provides evidence for a role of…”
Get full text

Understanding and Treating Alcohol Craving and Dependence: Recent Pharmacological and Neuroendocrinological Findings by Leggio, Lorenzo

“…There is a substantial need for discovering innovative ways to provide more information on the neurobiology of alcohol dependence as well as to discover more…”
Get full text

Biobehavioral effects of baclofen in anxious alcohol-dependent individuals: a randomized, double-blind, placebo-controlled, laboratory study by Farokhnia, M, Schwandt, M L, Lee, M R, Bollinger, J W, Farinelli, L A, Amodio, J P, Sewell, L, Lionetti, T A, Spero, D E, Leggio, L

“…Baclofen has been suggested as a potential pharmacotherapy for alcohol use disorder, but the clinical data are conflicting. Here we investigated the…”
Get full text

The glucagon-like peptide-1 receptor as a potential treatment target in alcohol use disorder: evidence from human genetic association studies and a mouse model of alcohol dependence by Suchankova, P, Yan, J, Schwandt, M L, Stangl, B L, Caparelli, E C, Momenan, R, Jerlhag, E, Engel, J A, Hodgkinson, C A, Egli, M, Lopez, M F, Becker, H C, Goldman, D, Heilig, M, Ramchandani, V A, Leggio, L

“…The hormone glucagon-like peptide-1 (GLP-1) regulates appetite and food intake. GLP-1 receptor (GLP-1R) activation also attenuates the reinforcing properties…”
Get full text

Mechanism of translation control of the alternative Drosophila melanogaster Voltage Dependent Anion-selective Channel 1 mRNAs by Leggio, L., Guarino, F., Magrì, A., Accardi-Gheit, R., Reina, S., Specchia, V., Damiano, F., Tomasello, M. F., Tommasino, M., Messina, A.

“…The eukaryotic porin, also called the Voltage Dependent Anion-selective Channel (VDAC), is the main pore-forming protein of the outer mitochondrial membrane…”
Get full text

Leptin levels are reduced by intravenous ghrelin administration and correlated with cue-induced alcohol craving by Haass-Koffler, C L, Aoun, E G, Swift, R M, de la Monte, S M, Kenna, G A, Leggio, L

“…Increasing evidence supports the role of appetite-regulating pathways, including ghrelin and leptin, in alcoholism. This study tested the hypothesis that…”
Get full text

Beam-shaping design for multi-wavelength diode laser stack system coupled into optical fiber for biomedical applications by Leggio, L., Gallego, D., Gawali, S.B., Wiśniowski, B., de Varona, O.

“…Multispectral diode laser sources are extensively used for a variety of applications involving the identification of small objects based on their spectral…”
Get full text