Search Results - "Leggatt, G R"

Selective Expansion of High- or Low-Avidity Cytotoxic T Lymphocytes and Efficacy for Adoptive Immunotherapy by Alexander-Miller, Martha A., Leggatt, Graham R., Berzofsky, Jay A.

“…The conventional approach to cytotoxic T-lymphocyte (CTL) induction uses maximal antigen concentration with the intent of eliciting more CTL. However, the…”
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Papillomavirus Virus-like Particles for the Delivery of Multiple Cytotoxic T Cell Epitopes by Liu, Wen Jun, Liu, Xiao Song, Zhao, Kong Nan, Leggatt, Graham R., Frazer, Ian H.

“…Chimeric papillomavirus (PV) virus-like particles (VLPs) based on the bovine papillomavirus type 1 (BPV-1) L1 protein were constructed by replacing the…”
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Expression of the HPV16E7 oncoprotein by thymic epithelium is accompanied by disrupted T cell maturation and a failure of the thymus to involute with age by Malcolm, K M, Gill, J, Leggatt, G R, Boyd, R, Lambert, P, Frazer, I H

“…Transgenic mice expressing the E7 protein of HPV16 from the keratin 14 promoter demonstrate increasing thymic hypertrophy with age. This hypertrophy is…”
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Nonspecific Down-Regulation of CD8+T-Cell Responses in Mice Expressing Human Papillomavirus Type 16 E7 Oncoprotein from the Keratin-14 Promoter by Tindle, R W, Herd, K, Doan, T, Bryson, G, Leggatt, G R, Lambert, P, Frazer, I H, Street, M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Identification and diagnostic value of a major antibody epitope on the 12 kDa antigen from Echinococcus granulosus (hydatid disease) cyst fluid by Leggatt, G R, McManus, D P

“…An IgG1 monoclonal antibody (MoAb), designated C9E7H8, has been produced against an epitope on the 12 kDa antigen of Echinococcus granulosus cyst fluid,…”
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The ultrastructural localization of Echinococcus granulosus antigen 5 by Jones, M K, Zhang, L H, Leggatt, G R, Stenzel, D J, McManus, D P

“…Murine monoclonal and polyclonal antisera, raised against the 38 kDa subunit of Echinococcus granulosus antigen 5, were used to investigate the tissue…”
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Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL by Alexander-Miller, M A, Leggatt, G R, Sarin, A, Berzofsky, J A

“…Experimental data suggest that negative selection of thymocytes can occur as a result of supraoptimal antigenic stimulation. It is unknown, however, whether…”
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Impaired Antigen Presentation and Effectiveness of Combined Active/Passive Immunotherapy for Epithelial Tumors by Matsumoto, Koji, Leggatt, Graham R., Zhong, Jie, Liu, Xiaosong, de Kluyver, Rachel L., Peters, Tania, Fernando, Germain J. P., Liem, Amy, Lambert, Paul F., Frazer, Ian H.

“…Background: Although immunization with tumor antigens can eliminate many transplantable tumors in animal models, immune effector mechanisms associated with…”
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Polynucleotide viral vaccines: codon optimisation and ubiquitin conjugation enhances prophylactic and therapeutic efficacy by Liu, Wen Jun, Zhao, Kong-Nan, Gao, Feng Guang, Leggatt, Graham R, Fernando, Germain J.P, Frazer, Ian H

“…Papillomavirus infection is a major antecedent of anogenital malignancy. We have previously established that the L1 and L2 capsid genes of papillomavirus have…”
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Sequence homology between two immunodiagnostic fusion proteins from Echinococcus multilocularis by Leggatt, G R, McManus, D P

“…Serological diagnosis of alveolar hydatid disease using crude parasite antigen is problematical with the result that several groups have addressed the question…”
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Chimeric Human Papilloma Virus–Simian/Human Immunodeficiency Virus Virus-like-Particle Vaccines: Immunogenicity and Protective Efficacy in Macaques by Dale, C.Jane, Liu, Xiaosong Song, De Rose, Robert, Purcell, Damian F.J., Anderson, Jenny, Xu, Yan, Leggatt, Graham R., Frazer, Ian H., Kent, Stephen J.

“…Vaccines to efficiently block or limit sexual transmission of both HIV and human papilloma virus (HPV) are urgently needed. Chimeric virus-like-particle (VLP)…”
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Potential strategies utilised by papillomavirus to evade host immunity by Frazer, Ian H., Thomas, Ranjeny, Zhou, Jian, Leggatt, Graham R., Dunn, Linda, McMillan, Nigel, Tindle, Robert W., Filgueira, Luis, Manders, Peter, Barnard, Paula, Sharkey, Michael

“…The co‐evolution of papillomaviruses (PV) and their mammalian hosts has produced mechanisms by which PV might avoid specific and non‐specific host immune…”
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Tolerance or Immunity to a Tumor Antigen Expressed in Somatic Cells Can Be Determined by Systemic Proinflammatory Signals at the Time of First Antigen Exposure by Frazer, Ian H, Kluyver, Rachel De, Leggatt, Graham R, Yang Guo, Hua, Dunn, Linda, White, Olivia, Harris, Craig, Liem, Amy, Lambert, Paul

“…Mice transgenic for the E7 tumor Ag of human papillomavirus type 16, driven from a keratin 14 promoter, express E7 in keratinocytes but not dendritic cells…”
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Further characterization of the 38 kDa antigen from Echinococcus granulosus (hydatid disease) cyst fluid: evidence for antigenic heterogeneity and reactivity with anti-P1 antibodies by Zhang, L H, Leggatt, G R, McManus, D P

“…A panel of 5 IgM and 6 IgG1 monoclonal antibodies (MoAbs) was produced against a band, eluted from a reducing SDS-PAGE gel, containing the 38 kDa subunit of…”
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Hydatid immunoblot test and cross-reactivity with sera from patients with cysticercosis by McManus, D P, Leggatt, G R

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Prevention and treatment of papillomavirus-related cancers through immunization by Frazer, Ian H, Leggatt, Graham R, Mattarollo, Stephen R

“…Cervical and other anogenital cancers are initiated by infection with one of a small group of human papillomaviruses (HPV). Virus-like particle-based vaccines…”
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Cytotoxic T-cell adherence assay (CAA) by Leggatt, G R, Berzofsky, J A

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Changes to peptide structure, not concentration, contribute to expansion of the lowest avidity cytotoxic T lymphocytes by Leggatt, Graham R., Narayan, Sharmal, Fernando, Germain J. P., Frazer, Ian H.

“…The efficient in vitro expansion of antigen‐specific CD8+ cytotoxic T lymphocytes (CTL) for use in adoptive immunotherapy represents an important clinical…”
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Interferon-gamma enhances cytotoxic T lymphocyte recognition of endogenous peptide in keratinocytes without lowering the requirement for surface peptide by Leggatt, Graham R, Dunn, Linda A, De kluyver, Rachel L, Stewart, Trina, Frazer, Ian H

“…Keratinocytes expressing the human papillomavirus (HPV) type 16 E7 protein, as a transgene driven by the K14 promoter, form a murine model of HPV‐mediated…”
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Inactivation of human immunodeficiency virus (HIV)-1 envelope-specific CD8+ cytotoxic T lymphocytes by free antigenic peptide: a self-veto mechanism? by Takahashi, H, Nakagawa, Y, Leggatt, G R, Ishida, Y, Saito, T, Yokomuro, K, Berzofsky, J A

“…Free peptide has been found to inhibit cytotoxic T lymphocyte (CTL) activity, and veto cells bearing peptide-major histocompatibility complex (MHC) complexes…”
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