Search Results - "Leger, Thibaut"

Guanine glycation repair by DJ-1/Park7 and its bacterial homologs by Richarme, Gilbert, Liu, Cailing, Mihoub, Mouadh, Abdallah, Jad, Leger, Thibaut, Joly, Nicolas, Liebart, Jean-Claude, Jurkunas, Ula V., Nadal, Marc, Bouloc, Philippe, Dairou, Julien, Lamouri, Aazdine

“…DNA damage induced by reactive carbonyls (mainly methylglyoxal and glyoxal), called DNA glycation, is quantitatively as important as oxidative damage. DNA…”
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Metabolomic and proteomic investigations of impacts of titanium dioxide nanoparticles on Escherichia coli by Planchon, Mariane, Léger, Thibaut, Spalla, Olivier, Huber, Gaspard, Ferrari, Roselyne

“…In a previous study, it was demonstrated that the toxic impact of titanium dioxide nanoparticles on Escherichia coli starts at 10 ppm and is closely related to…”
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Fate and PPARγ and STATs-driven effects of the mitochondrial complex I inhibitor tebufenpyrad in liver cells revealed with multi-omics by Léger, Thibaut, Balaguer, Patrick, Le Hégarat, Ludovic, Fessard, Valérie

“…The biological effects of the pesticide and mitochondrial complex I inhibitor tebufenpyrad (TEBU) on liver cells were investigated by combining proteomics and…”
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Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells by Ribeiro-Parenti, Lara, Jarry, Anne-Charlotte, Cavin, Jean-Baptiste, Willemetz, Alexandra, Le Beyec, Johanne, Sannier, Aurélie, Benadda, Samira, Pelletier, Anne-Laure, Hourseau, Muriel, Léger, Thibaut, Morlet, Bastien, Couvelard, Anne, Anini, Younes, Msika, Simon, Marmuse, Jean-Pierre, Ledoux, Sévérine, Le Gall, Maude, Bado, André

“…Glucagon-Like Peptide-1 (GLP-1) undergoes rapid inactivation by dipeptidyl peptidase-4 (DPP4) suggesting that target receptors may be activated by locally…”
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Acetaminophen metabolism revisited using non-targeted analyses: Implications for human biomonitoring by David, Arthur, Chaker, Jade, Léger, Thibaut, Al-Salhi, Raghad, Dalgaard, Marlene D., Styrishave, Bjarne, Bury, Daniel, Koch, Holger M., Jégou, Bernard, Kristensen, David M.

“…•Non-targeted HRMS method identified overlooked acetaminophen metabolites in human.•Thiomethyl metabolites showed delayed appearance with peak time at 24 h in…”
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LGP2 binds to PACT to regulate RIG-I- and MDA5-mediated antiviral responses by Sanchez David, Raul Y, Combredet, Chantal, Najburg, Valérie, Millot, Gael A, Beauclair, Guillaume, Schwikowski, Benno, Léger, Thibaut, Camadro, Jean-Michel, Jacob, Yves, Bellalou, Jacques, Jouvenet, Nolwenn, Tangy, Frédéric, Komarova, Anastassia V

“…The retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) RIG-I, MDA5, and LGP2 stimulate inflammatory and antiviral responses by sensing nonself RNA…”
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A Simple Light Isotope Metabolic Labeling (SLIM-labeling) Strategy: A Powerful Tool to Address the Dynamics of Proteome Variations In Vivo by Léger, Thibaut, Garcia, Camille, Collomb, Laetitia, Camadro, Jean-Michel

“…Many quantitative proteomics strategies rely on in vivo metabolic incorporation of amino acids with modified stable isotope profiles into proteins. These…”
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Imaging mass spectrometry reveals modified forms of histone H4 as new biomarkers of microvascular invasion in hepatocellular carcinomas by Poté, Nicolas, Alexandrov, Theodore, Le Faouder, Julie, Laouirem, Samira, Léger, Thibaut, Mebarki, Mouniya, Belghiti, Jacques, Camadro, Jean‐Michel, Bedossa, Pierre, Paradis, Valérie

“…Microvascular invasion (MiVI) is a major risk factor in postoperative tumor recurrence and mortality in hepatocellular carcinoma (HCC). Unfortunately, this…”
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The Metacaspase (Mca1p) has a Dual Role in Farnesol-induced Apoptosis in Candida albicans by Léger, Thibaut, Garcia, Camille, Ounissi, Marwa, Lelandais, Gaëlle, Camadro, Jean-Michel

“…Manipulating the apoptotic response of Candida albicans may help in the control of this opportunistic pathogen. The metacaspase Mca1p has been described as a…”
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Transportin-1 binds to the HIV-1 capsid via a nuclear localization signal and triggers uncoating by Fernandez, Juliette, Machado, Anthony K., Lyonnais, Sébastien, Chamontin, Célia, Gärtner, Kathleen, Léger, Thibaut, Henriquet, Corinne, Garcia, Camille, Portilho, Débora M., Pugnière, Martine, Chaloin, Laurent, Muriaux, Delphine, Yamauchi, Yohei, Blaise, Mickaël, Nisole, Sébastien, Arhel, Nathalie J.

“…The initial steps of HIV replication in host cells prime the virus for passage through the nuclear pore and drive the establishment of a productive and…”
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Serum proteomic profiling reveals fragments of MYOM3 as potential biomarkers for monitoring the outcome of therapeutic interventions in muscular dystrophies by Rouillon, Jérémy, Poupiot, Jérôme, Zocevic, Aleksandar, Amor, Fatima, Léger, Thibaut, Garcia, Camille, Camadro, Jean-Michel, Wong, Brenda, Pinilla, Robin, Cosette, Jérémie, Coenen-Stass, Anna M L, Mcclorey, Graham, Roberts, Thomas C, Wood, Matthew J A, Servais, Laurent, Udd, Bjarne, Voit, Thomas, Richard, Isabelle, Svinartchouk, Fedor

“…Therapy-responsive biomarkers are an important and unmet need in the muscular dystrophy field where new treatments are currently in clinical trials. By using a…”
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Cdk1 phosphorylates SPAT-1/Bora to trigger PLK-1 activation and drive mitotic entry in C. elegans embryos by Tavernier, Nicolas, Noatynska, Anna, Panbianco, Costanza, Martino, Lisa, Van Hove, Lucie, Schwager, Françoise, Léger, Thibaut, Gotta, Monica, Pintard, Lionel

“…The molecular mechanisms governing mitotic entry during animal development are incompletely understood. Here, we show that the mitotic kinase CDK-1…”
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Central role for ferritin in the day/night regulation of iron homeostasis in marine phytoplankton by Botebol, Hugo, Lesuisse, Emmanuel, Šuták, Robert, Six, Christophe, Lozano, Jean-Claude, Schatt, Philippe, Vergé, Valérie, Kirilovsky, Amos, Morrissey, Joe, Léger, Thibaut, Camadro, Jean-Michel, Gueneugues, Audrey, Bowler, Chris, Blain, Stéphane, Bouget, François-Yves

“…In large regions of the open ocean, iron is a limiting resource for phytoplankton. The reduction of iron quota and the recycling of internal iron pools are…”
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Redox modifications of cysteine-containing proteins, cell cycle arrest and translation inhibition: Involvement in vitamin C-induced breast cancer cell death by El Banna, Nadine, Hatem, Elie, Heneman-Masurel, Amélie, Léger, Thibaut, Baïlle, Dorothée, Vernis, Laurence, Garcia, Camille, Martineau, Sylvain, Dupuy, Corinne, Vagner, Stéphan, Camadro, Jean-Michel, Huang, Meng-Er

“…Vitamin C (VitC) possesses pro-oxidant properties at high pharmacologic concentrations which favor repurposing VitC as an anti-cancer therapeutic agent…”
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Variations of secretome profiles according to conditioned medium preparation: The example of human mesenchymal stem cell-derived adipocytes by Clabaut, Aline, Grare, Céline, Léger, Thibaut, Hardouin, Pierre, Broux, Odile

“…One challenging point in analyzing cellular secretome collected as conditioned medium is cross‐contamination by cell culture media components, especially…”
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Quantitative proteomics in Friedreich's ataxia B-lymphocytes: A valuable approach to decipher the biochemical events responsible for pathogenesis by Télot, Lorène, Rousseau, Elodie, Lesuisse, Emmanuel, Garcia, Camille, Morlet, Bastien, Léger, Thibaut, Camadro, Jean-Michel, Serre, Valérie

“…Friedreich's ataxia (FRDA) represents the most frequent type of autosomal-recessively inherited ataxia and is caused by the deficiency of frataxin, a…”
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Yersinia pseudotuberculosis Effector YopJ Subverts the Nod2/RICK/TAK1 Pathway and Activates Caspase-1 to Induce Intestinal Barrier Dysfunction by Meinzer, Ulrich, Barreau, Frederick, Esmiol-Welterlin, Sophie, Jung, Camille, Villard, Claude, Léger, Thibaut, Ben-Mkaddem, Sanah, Berrebi, Dominique, Dussaillant, Monique, Alnabhani, Ziad, Roy, Maryline, Bonacorsi, Stéphane, Wolf-Watz, Hans, Perroy, Julie, Ollendorff, Vincent, Hugot, Jean-Pierre

“…Yersinia pseudotuberculosis is an enteropathogenic bacteria that disrupts the intestinal barrier and invades its host through gut-associated lymphoid tissue…”
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The Metacaspase (Mca1p) Restricts O-glycosylation During Farnesol-induced Apoptosis in Candida albicans by Léger, Thibaut, Garcia, Camille, Camadro, Jean-Michel

“…Protein glycolysation is an essential posttranslational modification in eukaryotic cells. In pathogenic yeasts, it is involved in a large number of biological…”
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Over‐expression of Dyrk1A affects bleeding by modulating plasma fibronectin and fibrinogen level in mice by Postic, Guillaume, Solarz, Jean, Loubière, Cécile, Kandiah, Janany, Sawmynaden, Jaysen, Adam, Frederic, Vilaire, Marie, Léger, Thibaut, Camadro, Jean‐Michel, Victorino, Daniella Balduino, Potier, Marie‐Claude, Bun, Eric, Moroy, Gautier, Kauskot, Alexandre, Christophe, Olivier, Janel, Nathalie

“…Down syndrome is the most common chromosomal abnormality in humans. Patients with Down syndrome have hematologic disorders, including mild to moderate…”
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Galectin-8 Favors the Presentation of Surface-Tethered Antigens by Stabilizing the B Cell Immune Synapse by Obino, Dorian, Fetler, Luc, Soza, Andrea, Malbec, Odile, Saez, Juan José, Labarca, Mariana, Oyanadel, Claudia, Del Valle Batalla, Felipe, Goles, Nicolas, Chikina, Aleksandra, Lankar, Danielle, Segovia-Miranda, Fabián, Garcia, Camille, Léger, Thibaut, Gonzalez, Alfonso, Espéli, Marion, Lennon-Duménil, Ana-Maria, Yuseff, Maria-Isabel

“…Complete activation of B cells relies on their capacity to extract tethered antigens from immune synapses by either exerting mechanical forces or promoting…”
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