Search Results - "Leger, Andrew J"

Targeting nuclear RNA for in vivo correction of myotonic dystrophy by Wheeler, Thurman M., Leger, Andrew J., Pandey, Sanjay K., MacLeod, A. Robert, Nakamori, Masayuki, Cheng, Seng H., Wentworth, Bruce M., Bennett, C. Frank, Thornton, Charles A.

“…Nuclear-retained transcripts containing expanded repeats are shown to be sensitive to antisense silencing, and in a transgenic mouse model of myotonic…”
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Protease-activated receptors in cardiovascular diseases by LEGER, Andrew J, COVIC, Lidija, KULIOPULOS, Athan

“…Thrombosis associated with the pathophysiological activation of platelets and vascular cells has brought thrombin and its receptors to the forefront of…”
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Platelet Matrix Metalloprotease-1 Mediates Thrombogenesis by Activating PAR1 at a Cryptic Ligand Site by Trivedi, Vishal, Boire, Adrienne, Tchernychev, Boris, Kaneider, Nicole C., Leger, Andrew J., O'Callaghan, Katie, Covic, Lidija, Kuliopulos, Athan

“…Matrix metalloproteases (MMPs) play important roles in normal and pathological remodeling processes including atherothrombotic disease, inflammation,…”
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'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage by Covic, Lidija, Leger, Andrew J, Perides, George, Kuliopulos, Athan, Nguyen, Nga, Derian, Claudia, Agarwal, Anika, Kaneider, Nicole C

“…Sepsis is a deadly disease characterized by considerable derangement of the proinflammatory, anti-inflammatory and coagulation responses. Protease-activated…”
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Therapeutic targeting of molecules involved in leukocyte–endothelial cell interactions by Kaneider, Nicole C., Leger, Andrew J., Kuliopulos, Athan

“…Inflammation is traditionally viewed as a physiological reaction to tissue injury. Leukocytes contribute to the inflammatory response by the secretion of…”
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Antisense Oligonucleotide-mediated Suppression of Muscle Glycogen Synthase 1 Synthesis as an Approach for Substrate Reduction Therapy of Pompe Disease by Clayton, Nicholas P, Nelson, Carol A, Weeden, Timothy, Taylor, Kristin M, Moreland, Rodney J, Scheule, Ronald K, Phillips, Lucy, Leger, Andrew J, Cheng, Seng H, Wentworth, Bruce M

“…Pompe disease is an autosomal recessive disorder caused by a deficiency of acid α-glucosidase (GAA; EC 3.2.1.20) and the resultant progressive lysosomal…”
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Inhibition of osteoclastogenesis by prolyl hydroxylase inhibitor dimethyloxallyl glycine by Leger, Andrew J, Altobelli, Allison, Mosquea, Leocadia M, Belanger, Adam J, Song, Antonius, Cheng, Seng H, Jiang, Canwen, Yew, Nelson S

“…Studies examining the effects of hypoxia upon osteoclast biology have consistently revealed a stimulatory effect; both osteoclast differentiation and…”
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Allosteric Activation of a G Protein-coupled Receptor with Cell-penetrating Receptor Mimetics by Zhang, Ping, Leger, Andrew J., Baleja, James D., Rana, Rajashree, Corlin, Tiffany, Nguyen, Nga, Koukos, Georgios, Bohm, Andrew, Covic, Lidija, Kuliopulos, Athan

“…G protein-coupled receptors (GPCRs) are remarkably versatile signaling systems that are activated by a large number of different agonists on the outside of the…”
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Blocking the protease-activated receptor 1-4 heterodimer in platelet-mediated thrombosis by LEGER, Andrew J, JACQUES, Suzanne L, BADAR, Jehangir, KANEIDER, Nicole C, DERIAN, Claudia K, ANDRADE-GORDON, Patricia, COVIC, Lidija, KULIOPULOS, Athan

“…Thrombin is the most potent agonist of platelets and plays a critical role in the development of arterial thrombosis. Human platelets express dual thrombin…”
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Reversing systemic inflammatory response syndrome with chemokine receptor pepducins by Kuliopulos, Athan, Kaneider, Nicole C, Agarwal, Anika, Leger, Andrew J

“…We describe a new therapeutic approach for the treatment of lethal sepsis using cell-penetrating lipopeptides-termed pepducins-that target either individual or…”
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Systemic delivery of a Peptide-linked morpholino oligonucleotide neutralizes mutant RNA toxicity in a mouse model of myotonic dystrophy by Leger, Andrew J, Mosquea, Leocadia M, Clayton, Nicholas P, Wu, I-Huan, Weeden, Timothy, Nelson, Carol A, Phillips, Lucy, Roberts, Errin, Piepenhagen, Peter A, Cheng, Seng H, Wentworth, Bruce M

“…Expansions of CUG trinucleotide sequences in RNA transcripts provide the basis for toxic RNA gain-of-function that leads to detrimental changes in RNA…”
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Role of the PAR1 receptor 8th helix in signaling: the 7-8-1 receptor activation mechanism by Swift, Steven, Leger, Andrew J, Talavera, Joyce, Zhang, Lei, Bohm, Andrew, Kuliopulos, Athan

“…The protease-activated receptors are tethered ligand G protein-coupled receptors that are activated by proteolytic cleavage of the extracellular domain of the…”
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Adeno-associated virus-mediated expression of acid sphingomyelinase decreases atherosclerotic lesion formation in apolipoprotein E−/− mice by Leger, Andrew J., Mosquea, Leocadia M., Li, Lingyun, Chuang, WeiLien, Pacheco, Joshua, Taylor, Kristin, Luo, Zhengyu, Piepenhagen, Peter, Ziegler, Robin, Moreland, Rod, Urabe, Akihiro, Jiang, Canwen, Cheng, Seng H., Yew, Nelson S.

“…Background The secretory form of acid sphingomyelinase (ASM) is postulated to play a key role in the retention and aggregation of lipoproteins in the…”
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Role of the PAR1 Receptor 8th Helix in Signaling by Swift, Steven, Leger, Andrew J., Talavera, Joyce, Zhang, Lei, Bohm, Andrew, Kuliopulos, Athan

“…The protease-activated receptors are tethered ligand G protein-coupled receptors that are activated by proteolytic cleavage of the extracellular domain of the…”
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Antisense oligonucleotide-mediated suppression of muscle glycogen synthase 1 synthesis as an approach for substrate reduction therapy of Pompe disease by Clayton, Nicholas P., Nelson, Carol A., Weeden, Timothy, Taylor, Kristin M., Moreland, Rodney J., Scheule, Ronald K., Leger, Andrew J., Phillips, Lucy, Cheng, Seng H., Wentworth, Bruce M.

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Targeting nuclear RNA for in vivo correction of myotonic dystrophy by Wheeler, Thurman M, Leger, Andrew J, Pandey, Sanjay K, MacLeod, A Robert, Nakamori, Masayuki, Cheng, Seng H, Wentworth, Bruce M, Bennett, C Frank, Thornton, Charles A

“…Antisense oligonucleotides (ASOs) hold promise for gene-specific knockdown in diseases that involve RNA or protein gain-of-function effects. In the hereditary…”
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Identification and Targeting of a PAR1-PAR4 Complex in Human Platelets and Thrombosis by Leger, Andrew J., Covic, Lidija, Kuliopulos, Athan

“…Thrombin is the most potent activator of platelets and plays a crucial role in the development of arterial thrombosis. Human platelets express dual thrombin…”
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MINIREVIEW: Therapeutic targeting of molecules involved in leukocyte-endothelial cell interactions by Kaneider, Nicole C, Leger, Andrew J, Kuliopulos, Athan

“…Inflammation is traditionally viewed as a physiological reaction to tissue injury. Leukocytes contribute to the inflammatory response by the secretion of…”
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