Search Results - "Lega, J. C."

Survival and prognosis factors in systemic sclerosis: data of a French multicenter cohort, systematic review, and meta-analysis of the literature by Pokeerbux, M R, Giovannelli, J, Dauchet, L, Mouthon, L, Agard, C, Lega, J C, Allanore, Y, Jego, P, Bienvenu, B, Berthier, S, Mekinian, A, Hachulla, E, Launay, D

“…Data on survival and prognosis factors in incident cohorts are scarce in systemic sclerosis (SStc). To describe survival, standardized mortality ratio (SMR),…”
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Publication bias in pharmacogenetics of adverse reaction to antiseizure drugs: An umbrella review and a meta-epidemiological study by Bally, S, Cottin, J, Gagnieu, M C, Lega, J C, Verstuyft, C, Rheims, S, Lesca, G, Cucherat, M, Grenet, Guillaume

“…Publication bias may lead to a misestimation in the association between pharmacogenetic biomarkers (PGx) and antiseizure drug's adverse effects (AEs). We aimed…”
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Twice- or Once-Daily Dosing of Direct Oral Anticoagulants, a systematic review and meta-analysis by Mainbourg, S., Cucherat, M., Provencher, S., Bertoletti, L., Nony, P., Gueyffier, F., Mismetti, P., Grange, C., Durieu, I., Kilo, R., Laporte, S., Grenet, G., Lega, J.-C.

“…The direct oral anticoagulants (DOAC) have similar half-lives, but the dosing regimen varies between once daily (QD) or twice daily (BID). For some…”
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Natriuretic peptides and troponins in pulmonary embolism: a meta-analysis by Lega, J-C, Lacasse, Y, Lakhal, L, Provencher, S

“…The role of biomarkers such as B-type natriuretic peptides (BNP and NT-proBNP) and troponins in risk stratification of acute pulmonary embolism (APE) is still…”
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Consistency of safety profile of new oral anticoagulants in patients with renal failure by Lega, J.‐C., Bertoletti, L., Gremillet, C., Boissier, C., Mismetti, P., Laporte, S.

“…Summary Background The use of new oral anticoagulants (NOACs) in patients with impaired renal function has raised major concerns, in particular the possibility…”
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Assessment of clinically relevant bleeding as a surrogate outcome for major bleeding: validation by meta‐analysis of randomized controlled trials by Laporte, S., Chapelle, C., Bertoletti, L., Ollier, E., Zufferey, P., Lega, J.‐C., Merah, A., Décousus, H., Schulman, S., Meyer, G., Cucherat, M., Mismetti, P.

“…Essentials Surrogacy of clinically relevant bleeding (CRB) for major bleeding has never been validated. Our meta‐analysis evaluated CRB surrogacy in trials of…”
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Murine typhus complicated by sHLH mimicking adult-onset Still's disease by Jacquot, R., Gerfaud-Valentin, M., Lega, J.-C., Becker, A., Jamilloux, Y., Seve, P.

“…Adult-onset Still's disease (AOSD) is a rare multisystemic disorder and a diagnostic challenge for physicians because of the wide range of differential…”
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Issues and limitations of available biomarkers for fluoropyrimidine-based chemotherapy toxicity, a narrative review of the literature by Hodroj, K., Barthelemy, D., Lega, J.-C., Grenet, G., Gagnieu, M.-C., Walter, T., Guitton, J., Payen-Gay, L.

“…Fluoropyrimidine-based chemotherapies are widely used to treat gastrointestinal tract, head and neck, and breast carcinomas. Severe toxicities mostly impact…”
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Off-label use of biologics for the treatment of refractory and/or relapsing granulomatosis with polyangiitis by Mettler, C., Durel, CA, Guilpain, P., Bonnotte, B., Cohen-Aubart, F., Hamidou, M., Lega, JC, Guern, V. Le, Lifermann, F., Poindron, V., Pugnet, G., Servettaz, A., Puéchal, X., Guillevin, L., Terrier, B.

“…•In GPA, relapses remain frequent and refractory manifestations may occur.•Off-label use of TNF-α blockers shows efficacy in less than 50% of refractory and/or…”
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Impact of double‐blind vs. open study design on the observed treatment effects of new oral anticoagulants in atrial fibrillation: a meta‐analysis by Lega, J.‐C., Mismetti, P., Cucherat, M., Fassier, T., Bertoletti, L., Chapelle, C., Laporte, S.

“…Summary Background The prospective, randomized, open, blinded endpoint evaluation (PROBE) design has been proposed as a valid alternative to the double‐blind…”
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Impact of the 2009 Afssaps guidelines on the management of venous thromboembolic disease in emergency department: Before/after study by De Massari, L, Jamilloux, Y, Lega, J-C, Sigal, A, Jacob, X, Tazarourte, K, Mensah, K, Sève, P

“…The French Agency for Health Safety of Products published recommendations of good practices (RGP) for the treatment of venous thromboembolic disease in 2009…”
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Response to: Paradoxical embolism as a cause of renal and/or splenic infarction by Weber, E, Lega, J C

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Secondary ITP in adults by Michel, M, Lega, J-C, Terriou, L

“…Secondary forms of immune thrombocytopenia (ITP) represent approximately 20% of all ITP cases in adulthood and this rate increases with age. Since some causes…”
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Direct oral anticoagulants in the treatment of acute venous thromboembolism in patients with obesity: A systematic review with meta-analysis by Mai, V., Marceau-Ferron, E., Bertoletti, L., Lacasse, Y., Bonnet, S., Lega, J.C., Provencher, S.

“…[Display omitted] •DOAC seem as effective as VKA/LMWH in preventing VTE recurrence in patients with obesity and morbid obesity.•DOAC reduce the risk of MB…”
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Isolated recurrent pleuritis revealing familial mediterranean Fever in adulthood by Lega, J C, Khouatra, C, Cottin, V, Cordier, J F

“…Familial Mediterranean fever (FMF) is a genetic autoinflammatory disease especially affecting populations of Mediterranean origin with an autosomal recessive…”
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DOAC compared to LMWH in the treatment of cancer related-venous thromboembolism: a systematic review and meta-analysis by Mai, V., Tanguay, V. F., Guay, C. A., Bertoletti, L., Magnan, S., Turgeon, A. F., Lacasse, Y., Lega, J. C., Provencher, S.

“…Low molecular weight heparins (LMWH) are the standard of care for the treatment of cancer-associated venous thromboembolism (CA-VTE). We performed a systematic…”
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Acute renal and splenic infarctions: a review by Weber, E, Grangeon, F, Reynaud, Q, Hot, A, Sève, P, Jardel, S, Tazarourte, K, Fouque, D, Juillard, L, Salles, G, Grange, C, Durieu, I, Rousset, P, Lega, J C

“…Abstract Background Renal and splenic infarctions are close entities, with few data concerning their clinical, biological and radiological features. Aim The…”
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Contraceptive practices and cervical screening in women with cystic fibrosis by Rousset Jablonski, C., Reynaud, Q., Perceval, M., Nove-Josserand, R., Durupt, S., Lega, J.C., Durieu, I.

“…STUDY QUESTION Is gynaecological management of women with cystic fibrosis (CF) adequate? SUMMARY ANSWER Gynaecological care (frequency of follow-up, cervical…”
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Human papillomavirus and systemic lupus erythematosus by David, E, Belot, A, Lega, J-C, Durieu, I, Rousset-Jablonski, C

“…Infection with human papillomavirus (HPV) is one of the most widespread sexually transmitted diseases and the main risk factor for cervical cancer. Underlying…”
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Outcomes following a negative computed tomography pulmonary angiography according to pulmonary embolism prevalence: a meta‐analysis of the management outcome studies by Belzile, D., Jacquet, S., Bertoletti, L., Lacasse, Y., Lambert, C., Lega, J. C., Provencher, S.

“…Essentials Computed tomographic pulmonary angiography (CTPA) is used to exclude pulmonary embolism. This meta‐analysis explores the occurrence of venous…”
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