Search Results - "Lefrançois, L"

Common dysregulation of Wnt Frizzled receptor elements in human hepatocellular carcinoma by Bengochea, A, de Souza, M M, Lefrançois, L, Le Roux, E, Galy, O, Chemin, I, Kim, M, Wands, J R, Trepo, C, Hainaut, P, Scoazec, J-Y, Vitvitski, L, Merle, P

“…Dysregulation of growth factors and their receptors is central to human hepatocellular carcinoma (HCC). We previously demonstrated that the Frizzled-7 membrane…”
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Guarding the perimeter: protection of the mucosa by tissue-resident memory T cells by Cauley, L S, Lefrançois, L

“…Mucosal tissues are continually bombarded with infectious agents seeking to gain entry into the body. The absence of a tough physical exterior layer…”
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Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue by Masopust, David, Vezys, Vaiva, Marzo, Amanda L., Lefrançois, Leo

“…Many intracellular pathogens infect a broad range of host tissues, but the importance of T cells for immunity in these sites is unclear because most of our…”
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Differentiation of distinct long-lived memory CD4 T cells in intestinal tissues after oral Listeria monocytogenes infection by Romagnoli, P A, Fu, H H, Qiu, Z, Khairallah, C, Pham, Q M, Puddington, L, Khanna, K M, Lefrançois, L, Sheridan, B S

“…Mucosal antigen-specific CD4 T-cell responses to intestinal pathogens remain incompletely understood. Here we examined the CD4 T-cell response after oral…”
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Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo by Lefrançois, Leo, Schluns, Kimberly S, Kieper, William C, Jameson, Stephen C

“…The naïve and memory T lymphocyte pools are maintained through poorly understood homeostatic mechanisms that may include signaling via cytokine receptors. We…”
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Organ-Specific Regulation of the CD8 T Cell Response to Listeria monocytogenes Infection by Pope, Constance, Kim, Sung-Kwon, Marzo, Amanda, Williams, Kristina, Jiang, Jiu, Shen, Hao, Lefrancois, Leo

“…The intestinal mucosal CD8 T cell response to infection with Listeria monocytogenes was measured using MHC class I tetramers and was compared with the response…”
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Direct Analysis of the Dynamics of the Intestinal Mucosa CD8 T Cell Response to Systemic Virus Infection by Masopust, David, Jiang, Jiu, Shen, Hao, Lefrancois, Leo

“…The CD8 T cell response to vesicular stomatitis virus infection was characterized in the spleen and intestinal mucosa using MHC tetramers. Surprisingly, the…”
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Novel IL-15 isoforms generated by alternative splicing are expressed in the intestinal epithelium by Tan, X, Lefrançois, L

“…Previous studies have identified mRNA three isoforms encoding interleukin-15 (IL-15) that are produced through differential splicing and encode for the same…”
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Expression of Intestine-Specific Antigen Reveals Novel Pathways of CD8 T Cell Tolerance Induction by Vezys, Vaiva, Olson, Sara, Lefrançois, Leo

“…Reactivity to intestinal epithelium-specific antigen was studied by transgenic expression of cytosolic ovalbumin controlled by an enterocyte-specific promoter…”
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Expression of the γ-δ T-cell receptor on intestinal CD8 + intraepithelial lymphocytes by Goodman, Thomas, Lefrançois, Leo

“…The vast majority of mature T lymphocytes in the peripheral blood and lymphoid organs use the CD3-associated alpha, beta T-cell receptor (TCR) heterodimer for…”
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Induction and Visualization of Mucosal Memory CD8 T Cells Following Systemic Virus Infection by Kim, Sung-Kwon, Schluns, Kimberly S, Lefrancois, Leo

“…Whether CD8 T cell memory exists outside secondary lymphoid organs is unclear. Using an adoptive transfer system that enables tracking of OVA-specific CD8 T…”
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Antigen-driven induction of CD11c on intestinal intraepithelial lymphocytes and CD8+ T cells in vivo by Huleatt, JW, Lefrancois, L

“…Intraepithelial lymphocytes (IEL) of the intestinal epithelium represent a phenotypically and functionally distinct subpopulation of peripheral T cells. In…”
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Isolation of mouse small intestinal intraepithelial lymphocytes, Peyer's patch, and lamina propria cells by Lefrançois, L, Lycke, N

“…The intestinal mucosal immune system is composed of three major lymphoid areas: the lamina propria (LP), which lies just underneath the basement membrane in…”
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The Role of IL-7 in Thymic and Extrathymic Development of TCRγδ Cells by Laky, K., Lefrançois, L., von Freeden-Jeffry, U., Murray, R., Puddington, L.

“…Abstract IL-7-deficient (IL-7−/−) mice have reduced numbers of B and TCRαβ cells, but lack mature TCRγδ cells. Although most T cell development occurs in the…”
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Soluble Antigen and CD40 Triggering Are Sufficient to Induce Primary and Memory Cytotoxic T Cells by Lefrancois, Leo, Altman, John D, Williams, Kristina, Olson, Sara

“…The signals directing induction of tolerance rather than immunity are largely unknown. The CD8 T cell response to soluble Ags generally results in deletional…”
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Age-dependent intestinal lymphoproliferative disorder due to stem cell factor receptor deficiency: parameters in small and large intestine by Laky, K, Lefrancois, L, Puddington, L

“…Signaling through c-Kit/stem cell factor (SCF) is crucial for normal development of erythroid and myeloid hematopoietic precursors and of melanocytes and germ…”
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The role of IL-7 in thymic and extrathymic development of TCR gamma delta cells by Laky, K, Lefrançois, L, von Freeden-Jeffry, U, Murray, R, Puddington, L

“…IL-7-deficient (IL-7(-/-)) mice have reduced numbers of B and TCR alpha beta cells, but lack mature TCR gamma delta cells. Although most T cell development…”
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Interactions between stem cell factor and c-Kit are required for intestinal immune system homeostasis by Puddington, L, Olson, S, Lefrançois, L

“…Interactions between stem cell factor (SCF) and its receptor, c-Kit, are important for development of hematopoietic, melanocytes, and germ cells. T lymphocytes…”
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A novel pathway of thymus-directed T lymphocyte maturation by Lefrancois, L, Olson, S

“…Recent evidence has indicated that the intestinal epithelium may be a major extrathymic site of T cell production. However, which of the multiple intestinal…”
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DNA demethylation induces SALL4 gene re-expression in subgroups of hepatocellular carcinoma associated with Hepatitis B or C virus infection by Fan, H, Cui, Z, Zhang, H, Mani, S K, Diab, A, Lefrancois, L, Fares, N, Merle, P, Andrisani, O

“…Sal-like protein 4 (SALL4), an embryonic stem cell transcriptional regulator, is re-expressed by an unknown mechanism in poor prognosis hepatocellular…”
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