Search Results - "Lefevre, Isabel A"

Cerebrospinal fluid neurogranin in an inducible mouse model of neurodegeneration: A translatable marker of synaptic degeneration by Höglund, Kina, Schussler, Nathalie, Kvartsberg, Hlin, Smailovic, Una, Brinkmalm, Gunnar, Liman, Victor, Becker, Bruno, Zetterberg, Henrik, Cedazo-Minguez, Angel, Janelidze, Shorena, Lefevre, Isabel A., Eyquem, Stéphanie, Hansson, Oskar, Blennow, Kaj

“…Synapse impairment is thought to be an early event in Alzheimer's disease (AD); dysfunction and loss of synapses are linked to cognitive symptoms that precede…”
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Introduction to the EQIPD quality system by Bespalov, Anton, Bernard, René, Gilis, Anja, Gerlach, Björn, Guillén, Javier, Castagné, Vincent, Lefevre, Isabel A, Ducrey, Fiona, Monk, Lee, Bongiovanni, Sandrine, Altevogt, Bruce, Arroyo-Araujo, María, Bikovski, Lior, de Bruin, Natasja, Castaños-Vélez, Esmeralda, Dityatev, Alexander, Emmerich, Christoph H, Fares, Raafat, Ferland-Beckham, Chantelle, Froger-Colléaux, Christelle, Gailus-Durner, Valerie, Hölter, Sabine M, Hofmann, Martine Cj, Kabitzke, Patricia, Kas, Martien Jh, Kurreck, Claudia, Moser, Paul, Pietraszek, Malgorzata, Popik, Piotr, Potschka, Heidrun, Prado Montes de Oca, Ernesto, Restivo, Leonardo, Riedel, Gernot, Ritskes-Hoitinga, Merel, Samardzic, Janko, Schunn, Michael, Stöger, Claudia, Voikar, Vootele, Vollert, Jan, Wever, Kimberley E, Wuyts, Kathleen, MacLeod, Malcolm R, Dirnagl, Ulrich, Steckler, Thomas

“…While high risk of failure is an inherent part of developing innovative therapies, it can be reduced by adherence to evidence-based rigorous research…”
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Learning from Principles of Evidence-Based Medicine to Optimize Nonclinical Research Practices by Lefevre, Isabel A, Balice-Gordon, Rita J

“…Thousands of pharmacology experiments are performed each day, generating hundreds of drug discovery programs, scientific publications, grant submissions, and…”
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Functional Studies of Sodium Channels: From Target to Compound Identification by Bertrand, Daniel, Biton, Bruno, Licher, Thomas, Chambard, Jean-Marie, Lanneau, Christophe, Partiseti, Michel, Lefevre, Isabel A

“…Over the last six decades, voltage-gated sodium (Na ) channels have attracted a great deal of scientific and pharmaceutical interest, driving fundamental…”
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Systematic review of guidelines for internal validity in the design, conduct and analysis of preclinical biomedical experiments involving laboratory animalsSystematic review of guidelines for internal validity in the design, conduct and analysis of preclinical biomedical experiments involving laboratory animals by Vollert, Jan, Schenker, Esther, Macleod, Malcolm, Bespalov, Anton, Wuerbel, Hanno, Michel, Martin, Dirnagl, Ulrich, Potschka, Heidrun, Waldron, Ann-Marie, Wever, Kimberley, Steckler, Thomas, van de Casteele, Tom, Altevogt, Bruce, Sil, Annesha, Rice, Andrew S C, Clark, Judi, Sena, Emily, Boulanger, Bruno, Riedel, Gernot, Platt, Bettina, Kas, Martien J, Voelkl, Bernhard, Michel, Martin C, Jucker, Mathias, Wegenast-Braun, Bettina M, Bernard, René, Heiden, Esmeralda, Loos, Maarten, Wever, Kimberley E, Ritskes-Hoitinga, Merel, Casteele, Tom Van De, Drinkenburg, Pim, Pita Almenar, Juan Diego, Gallacher, David, Linde, Henk Van Der, Gilis, Anja, Teuns, Greet, Wicke, Karsten, Grote, Sabine, Sommer, Bernd, Nicholson, Janet, Janhunen, Sanna, Virtanen, Sami, Cheng, Kristin, Ramboz, Sylvie, Leahy, Emer, Lefevre, Isabel A, Ducrey, Fiona, Guillen, Javier, Vergara, Patri, Seiffert, Isabel

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Protocol for a systematic review of guidelines for rigour in the design, conduct and analysis of biomedical experiments involving laboratory animals by Vollert, Jan, Schenker, Esther, Macleod, Malcolm, Bespalov, Anton, Wuerbel, Hanno, Michel, Martin Christian, Dirnagl, Ulrich, Potschka, Heidrun, Wever, Kimberley E, Steckler, Thomas, Altevogt, Bruce, Rice, Andrew S C

“…ObjectiveWithin the last years, there has been growing awareness of the negative repercussions of unstandardized planning, conduct and reporting of preclinical…”
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Effect of 2,3-butanedione 2-monoxime on slow inward and transient outward currents in rat ventricular myocytes by Coulombe, A, Lefevre, I A, Deroubaix, E, Thuringer, D, Coraboeuf, E

“…The effect of 2,3-butanedione 2-monoxime (BDM), a substance possessing phosphatase-like activity, was studied on action potentials of isolated rat heart and on…”
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Effects of chloride ion substitutes and chloride channel blockers on the transient outward current in rat ventricular myocytes by Lefevre, Thierry, Lefevre, Isabel A., Coulombe, Alain, Coraboeuf, Edouard

“…The Ca i 2-insensitive transient outward current, i lo was studied at 20–24°C in rat ventricular myocytes with the whole cell recording patch-clamp technique…”
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