Search Results - "Lefebvre, Romain"

Investigation of orally delivered carbon monoxide for postoperative ileus by Van Dingenen, Jonas, Steiger, Christoph, Zehe, Markus, Meinel, Lorenz, Lefebvre, Romain A.

“…[Display omitted] Endogenously produced carbon monoxide (CO) has antioxidant and anti-inflammatory effects which is why CO has been investigated as a possible…”
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Differential Effects of CORM-2 and CORM-401 in Murine Intestinal Epithelial MODE-K Cells under Oxidative Stress by Babu, Dinesh, Leclercq, Georges, Motterlini, Roberto, Lefebvre, Romain A

“…Carbon monoxide (CO)-releasing molecules (CO-RMs) are intensively studied to provide cytoprotective and anti-inflammatory effects of CO in inflammatory…”
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Hemin reduces postoperative ileus in a heme oxygenase 1‐dependent manner while dimethyl fumarate does without heme oxygenase 1‐induction by Van Dingenen, Jonas, Pieters, Leen, Van Nuffel, Elien, Lefebvre, Romain A.

“…Background Postoperative ileus (POI), the impairment of gastrointestinal motility after abdominal surgery, is mainly due to intestinal muscular inflammation…”
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Myosin light chain phosphatase activation is involved in the hydrogen sulfide-induced relaxation in mouse gastric fundus by Dhaese, Ingeborg, Lefebvre, Romain A.

“…The relaxant effect of hydrogen sulfide (H 2S) in the vascular tree is well established but its influence and mechanism of action in gastrointestinal smooth…”
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The H2S-Releasing Naproxen Derivative ATB-346 and the Slow-Release H2S Donor GYY4137 Reduce Intestinal Inflammation and Restore Transit in Postoperative Ileus by Van Dingenen, Jonas, Pieters, Leen, Vral, Anne, Lefebvre, Romain A.

“…Objective: Intestinal inflammation triggers postoperative ileus (POI), commonly seen after abdominal surgery and characterized by impaired gastrointestinal…”
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Mechanisms of action of hydrogen sulfide in relaxation of mouse distal colonic smooth muscle by Dhaese, Ingeborg, Van Colen, Inge, Lefebvre, Romain A.

“…Hydrogen sulfide (H 2S) has been suggested as a gaseous neuromodulator in mammals. The aim of this study was to examine the influence of H 2S on contractility…”
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Mitochondria and NADPH oxidases are the major sources of TNF-α/cycloheximide-induced oxidative stress in murine intestinal epithelial MODE-K cells by Babu, Dinesh, Leclercq, Georges, Goossens, Vera, Vanden Berghe, Tom, Van Hamme, Evelien, Vandenabeele, Peter, Lefebvre, Romain A.

“…TNF-α/cycloheximide (CHX)-induced apoptosis of the mouse intestinal epithelial cell line MODE-K corresponds with the production of reactive oxygen species…”
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Antioxidant potential of CORM-A1 and resveratrol during TNF-α/cycloheximide-induced oxidative stress and apoptosis in murine intestinal epithelial MODE-K cells by Babu, Dinesh, Leclercq, Georges, Goossens, Vera, Remijsen, Quinten, Vandenabeele, Peter, Motterlini, Roberto, Lefebvre, Romain A.

“…Targeting excessive production of reactive oxygen species (ROS) could be an effective therapeutic strategy to prevent oxidative stress-associated…”
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cAMP Catalyzing Phosphodiesterases Control Cholinergic Muscular Activity But Their Inhibition Does Not Enhance 5-HT4 Receptor-Mediated Facilitation of Cholinergic Contractions in the Murine Gastrointestinal Tract by Pauwelyn, Vicky, Lefebvre, Romain A.

“…Background: As the signal transduction of 5-HT 4 receptors on cholinergic neurons innervating smooth muscle is controlled by phosphodiesterase (PDE) 4 in…”
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Synergistic effect between 5-HT4 receptor agonist and phosphodiesterase 4-inhibitor in releasing acetylcholine in pig gastric circular muscle in vitro by Lefebvre, Romain A., Van Colen, Inge, Pauwelyn, Vicky, De Maeyer, Joris H.

“…5-HT4 receptor agonists have a gastroprokinetic effect by facilitating acetylcholine release from cholinergic nerves innervating gastrointestinal smooth…”
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Presynaptic M3 muscarinic cholinoceptors mediate inhibition of excitatory synaptic transmission in area CA1 of rat hippocampus by de Vin, Filip, Choi, Sze Men, Bolognesi, Maria L, Lefebvre, Romain A

“…Abstract Acetylcholine can modulate hippocampal network function through activation of both nicotinic and muscarinic acetylcholine receptors (mAChRs). All five…”
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TNF-α/cycloheximide-induced oxidative stress and apoptosis in murine intestinal epithelial MODE-K cells by Babu, Dinesh, Soenen, Stefaan J, Raemdonck, Koen, Leclercq, Georges, De Backer, Ole, Motterlini, Roberto, Lefebvre, Romain A

“…In the mouse postoperative ileus model, we have shown an increase in oxidative stress after intestinal manipulation occurring earlier in the mucosa than in the…”
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The facilitating effect of prucalopride on cholinergic neurotransmission in pig gastric circular muscle is regulated by phosphodiesterase 4 by Priem, Evelien, Van Colen, Inge, De Maeyer, Joris H., Lefebvre, Romain A.

“…The influence of the selective 5-HT4 receptor agonist prucalopride on acetylcholine release from cholinergic nerve endings innervating pig gastric circular…”
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The influence of peptide impurity profiles on functional tissue–organ bath response: The 11-mer peptide INSL6[151–161] case by Verbeken, Mathieu, Wynendaele, Evelien, Lefebvre, Romain A., Goossens, Els, De Spiegeleer, Bart

“…Bioactive peptides have great pharmaceutical potential as nutraceuticals, diagnostics, and therapeutic drugs in several clinical areas. Thus, the search for…”
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Influence of phosphodiesterases and cGMP on cAMP generation and on phosphorylation of phospholamban and troponin I by 5-HT4 receptor activation in porcine left atrium by Weninger, Sabine, De Maeyer, Joris H., Lefebvre, Romain A.

“…Our objective was to investigate the role of phosphodiesterase (PDE)3 and PDE4 and cGMP in the control of cAMP metabolism and of phosphorylation of troponin I…”
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Peroxisome proliferator-activated receptor gamma activation alleviates postoperative ileus in mice by inhibition of Egr-1 expression and its downstream target genes by De Backer, Ole, Elinck, Ellen, Priem, Evelien, Leybaert, Luc, Lefebvre, Romain A

“…Postoperative ileus, a major cause of morbidity after abdominal surgery, is characterized by intestinal dysmotility and a complex inflammatory cascade within…”
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Investigation of neurogenic excitatory and inhibitory motor responses and their control by 5-HT₄ receptors in circular smooth muscle of pig descending colon by Priem, Evelien K.V, Lefebvre, Romain A

“…The aim of this study was to investigate whether the pig colon descendens might be a good model for the responses mediated via the different locations of human…”
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Influence of phosphodiesterases on basal and 5-HT4 receptor facilitated cholinergic contractility in pig descending colon by Priem, Evelien K.V., De Maeyer, Joris H., Lefebvre, Romain A.

“…This study in pig colon descendens circular muscle investigated the possible role of phosphodiesterases (PDEs) (1) in the control of smooth muscle activity and…”
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Mechanisms of relaxation by carbon monoxide-releasing molecule-2 in murine gastric fundus and jejunum by De Backer, Ole, Lefebvre, Romain A.

“…This study investigated the effects and mechanisms of action of carbon monoxide-releasing molecule-2 (CORM-2), compared to those of carbon monoxide (CO), in…”
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Porcine left atrial and sinoatrial 5‐HT 4 receptor‐induced responses: fading of the response and influence of development by De Maeyer, Joris H, Straetemans, Roel, Schuurkes, Jan A J, Lefebvre, Romain A

“…In this study, we aimed to characterize in vitro the effects of the benzofuran 5‐HT 4 receptor agonists prucalopride, R149402 and R199715 and the indolic…”
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