Search Results - "Lefai, Etienne"

Disruption of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Contributes to Muscle Insulin Resistance in Mice and Humans by Tubbs, Emily, Chanon, Stéphanie, Robert, Maud, Bendridi, Nadia, Bidaux, Gabriel, Chauvin, Marie-Agnès, Ji-Cao, Jingwei, Durand, Christine, Gauvrit-Ramette, Daphné, Vidal, Hubert, Lefai, Etienne, Rieusset, Jennifer

“…Modifications of the interactions between endoplasmic reticulum (ER) and mitochondria, defined as mitochondria-associated membranes (MAMs), were recently shown…”
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Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis by Geng, Feng, Cheng, Xiang, Wu, Xiaoning, Yoo, Ji Young, Cheng, Chunming, Guo, Jeffrey Yunhua, Mo, Xiaokui, Ru, Peng, Hurwitz, Brian, Kim, Sung-Hak, Otero, Jose, Puduvalli, Vinay, Lefai, Etienne, Ma, Jianjie, Nakano, Ichiro, Horbinski, Craig, Kaur, Balveen, Chakravarti, Arnab, Guo, Deliang

“…Elevated lipogenesis regulated by sterol regulatory element-binding protein-1 (SREBP-1), a transcription factor playing a central role in lipid metabolism, is…”
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Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice by Benoit, Bérengère, Meugnier, Emmanuelle, Castelli, Martina, Chanon, Stéphanie, Vieille-Marchiset, Aurélie, Durand, Christine, Bendridi, Nadia, Pesenti, Sandra, Monternier, Pierre-Axel, Durieux, Anne-Cécile, Freyssenet, Damien, Rieusset, Jennifer, Lefai, Etienne, Vidal, Hubert, Ruzzin, Jérôme

“…FGF19 acts directly on skeletal muscle to increase its mass, and treatment with the hormone ameliorates muscle atrophy in three mouse models. The…”
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AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice by Li, Yu, Xu, Shanqin, Mihaylova, Maria M., Zheng, Bin, Hou, Xiuyun, Jiang, Bingbing, Park, Ogyi, Luo, Zhijun, Lefai, Etienne, Shyy, John Y.-J., Gao, Bin, Wierzbicki, Michel, Verbeuren, Tony J., Shaw, Reuben J., Cohen, Richard A., Zang, Mengwei

“…AMPK has emerged as a critical mechanism for salutary effects of polyphenols on lipid metabolic disorders in type 1 and type 2 diabetes. Here we demonstrate…”
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Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth by Cheng, Chunming, Ru, Peng, Geng, Feng, Liu, Junfeng, Yoo, Ji Young, Wu, Xiaoning, Cheng, Xiang, Euthine, Vanessa, Hu, Peng, Guo, Jeffrey Yunhua, Lefai, Etienne, Kaur, Balveen, Nohturfft, Axel, Ma, Jianjie, Chakravarti, Arnab, Guo, Deliang

“…Tumorigenesis is associated with increased glucose consumption and lipogenesis, but how these pathways are interlinked is unclear. Here, we delineate a pathway…”
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Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle by Perrin, Laurent, Loizides-Mangold, Ursula, Chanon, Stéphanie, Gobet, Cédric, Hulo, Nicolas, Isenegger, Laura, Weger, Benjamin D, Migliavacca, Eugenia, Charpagne, Aline, Betts, James A, Walhin, Jean-Philippe, Templeman, Iain, Stokes, Keith, Thompson, Dylan, Tsintzas, Kostas, Robert, Maud, Howald, Cedric, Riezman, Howard, Feige, Jerome N, Karagounis, Leonidas G, Johnston, Jonathan D, Dermitzakis, Emmanouil T, Gachon, Frédéric, Lefai, Etienne, Dibner, Charna

“…Circadian regulation of transcriptional processes has a broad impact on cell metabolism. Here, we compared the diurnal transcriptome of human skeletal muscle…”
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Lipidomics reveals diurnal lipid oscillations in human skeletal muscle persisting in cellular myotubes cultured in vitro by Loizides-Mangold, Ursula, Perrin, Laurent, Vandereycken, Bart, Betts, James A., Walhin, Jean-Philippe, Templeman, Iain, Chanon, Stéphanie, Weger, Benjamin D., Durand, Christine, Robert, Maud, Montoya, Jonathan Paz, Moniatte, Marc, Karagounis, Leonidas G., Johnston, Jonathan D., Gachon, Frédéric, Lefai, Etienne, Riezman, Howard, Dibner, Charna

“…Circadian clocks play an important role in lipid homeostasis, with impact on various metabolic diseases. Due to the central role of skeletal muscle in…”
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Proteomic analysis of C2C12 myoblast and myotube exosome-like vesicles: a new paradigm for myoblast-myotube cross talk? by Forterre, Alexis, Jalabert, Audrey, Berger, Emmanuelle, Baudet, Mathieu, Chikh, Karim, Errazuriz, Elisabeth, De Larichaudy, Joffrey, Chanon, Stéphanie, Weiss-Gayet, Michèle, Hesse, Anne-Marie, Record, Michel, Geloen, Alain, Lefai, Etienne, Vidal, Hubert, Couté, Yohann, Rome, Sophie

“…Exosomes are nanometer-sized microvesicles formed in multivesicular bodies (MVBs) during endosome maturation. Exosomes are released from cells into the…”
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Hibernating brown bears are protected against atherogenic dyslipidemia by Giroud, Sylvain, Chery, Isabelle, Arrivé, Mathilde, Prost, Michel, Zumsteg, Julie, Heintz, Dimitri, Evans, Alina L., Gauquelin-Koch, Guillemette, Arnemo, Jon M., Swenson, Jon E., Lefai, Etienne, Bertile, Fabrice, Simon, Chantal, Blanc, Stéphane

“…To investigate mechanisms by which hibernators avoid atherogenic hyperlipidemia during hibernation, we assessed lipoprotein and cholesterol metabolisms of…”
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Exosomes participate in the alteration of muscle homeostasis during lipid-induced insulin resistance in mice by Aswad, Hala, Forterre, Alexis, Wiklander, Oscar P. B., Vial, Guillaume, Danty-Berger, Emmanuelle, Jalabert, Audrey, Lamazière, Antonin, Meugnier, Emmanuelle, Pesenti, Sandra, Ott, Catherine, Chikh, Karim, El-Andaloussi, Samir, Vidal, Hubert, Lefai, Etienne, Rieusset, Jennifer, Rome, Sophie

“…Aims/hypothesis Exosomes released from cells can transfer both functional proteins and RNAs between cells. In this study we tested the hypothesis that muscle…”
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Adipose Tissue-Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation by Eljaafari, Assia, Robert, Maud, Chehimi, Marwa, Chanon, Stephanie, Durand, Christine, Vial, Guillaume, Bendridi, Nadia, Madec, Anne-Marie, Disse, Emmanuel, Laville, Martine, Rieusset, Jennifer, Lefai, Etienne, Vidal, Hubert, Pirola, Luciano

“…Obesity, through low-grade inflammation, can drive insulin resistance and type 2 diabetes. While infiltration of adipose tissue (AT) with mononuclear cells…”
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Insulin resistance is associated with MCP1-mediated macrophage accumulation in skeletal muscle in mice and humans by Patsouris, David, Cao, Jingwei-Ji, Vial, Guillaume, Bravard, Amelie, Lefai, Etienne, Durand, Annie, Durand, Christine, Chauvin, Marie-Agnés, Laugerette, Fabienne, Debard, Cyrille, Michalski, Marie-Caroline, Laville, Martine, Vidal, Hubert, Rieusset, Jennifer

“…Inflammation is now recognized as a major factor contributing to type 2 diabetes (T2D). However, while the mechanisms and consequences associated with white…”
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SREBP-1 upregulates lipophagy to maintain cholesterol homeostasis in brain tumor cells by Geng, Feng, Zhong, Yaogang, Su, Huali, Lefai, Etienne, Magaki, Shino, Cloughesy, Timothy F., Yong, William H., Chakravarti, Arnab, Guo, Deliang

“…Cholesterol is a structural component of cell membranes. How rapidly growing tumor cells maintain membrane cholesterol homeostasis is poorly understood. Here,…”
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Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth by Ru, Peng, Hu, Peng, Geng, Feng, Mo, Xiaokui, Cheng, Chunming, Yoo, Ji Young, Cheng, Xiang, Wu, Xiaoning, Guo, Jeffrey Yunhua, Nakano, Ichiro, Lefai, Etienne, Kaur, Balveen, Chakravarti, Arnab, Guo, Deliang

“…Dysregulated lipid metabolism is a characteristic of malignancies. Sterol regulatory element binding protein 1 (SREBP-1), a transcription factor playing a…”
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MicroRNAs facilitate skeletal muscle maintenance and metabolic suppression in hibernating brown bears by Luu, Bryan E., Lefai, Etienne, Giroud, Sylvain, Swenson, Jon E., Chazarin, Blandine, Gauquelin‐Koch, Guillemette, Arnemo, Jon M., Evans, Alina L., Bertile, Fabrice, Storey, Kenneth B.

“…Hibernating brown bears, Ursus arctos, undergo extended periods of inactivity and yet these large hibernators are resilient to muscle disuse atrophy…”
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ANGPTL4 is a potential driver of HCV-induced peripheral insulin resistance by Gomes, Diana, Sobolewski, Cyril, Conzelmann, Stéphanie, Schaer, Tifany, Lefai, Etienne, Alfaiate, Dulce, Tseligka, Eirini D., Goossens, Nicolas, Tapparel, Caroline, Negro, Francesco, Foti, Michelangelo, Clément, Sophie

“…Chronic hepatitis C (CHC) is associated with the development of metabolic disorders, including both hepatic and extra-hepatic insulin resistance (IR). Here, we…”
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Myostatin gene inactivation prevents skeletal muscle wasting in cancer by Gallot, Yann S, Durieux, Anne-Cécile, Castells, Josiane, Desgeorges, Marine M, Vernus, Barbara, Plantureux, Léa, Rémond, Didier, Jahnke, Vanessa E, Lefai, Etienne, Dardevet, Dominique, Nemoz, Georges, Schaeffer, Laurent, Bonnieu, Anne, Freyssenet, Damien G

“…Cachexia is a muscle-wasting syndrome that contributes significantly to morbidity and mortality of many patients with advanced cancers. However, little is…”
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Hypergravity as a gravitational therapy mitigates the effects of knee osteoarthritis on the musculoskeletal system in a murine model by Dechaumet, Benoit, Cleret, Damien, Linossier, Marie-Thérèse, Vanden-Bossche, Arnaud, Chanon, Stéphanie, Lefai, Etienne, Laroche, Norbert, Lafage-Proust, Marie-Hélène, Vico, Laurence

“…Insights into the effects of osteoarthritis (OA) and physical interventions on the musculoskeletal system are limited. Our goal was to analyze musculoskeletal…”
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The Protective Effects on Ischemia–Reperfusion Injury Mechanisms of the Thoracic Aorta in Daurian Ground Squirrels (Spermophilus dauricus) over the Torpor–Arousal Cycle of Hibernation by Han, Yuting, Miao, Weilan, Hao, Ziwei, An, Ning, Yang, Yingyu, Zhang, Ziwen, Chen, Jiayu, Storey, Kenneth B., Lefai, Etienne, Chang, Hui

“…Hibernators are a natural model of vascular ischemia–reperfusion injury; however, the protective mechanisms involved in dealing with such an injury over the…”
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In-Depth Proteome Analysis Highlights HepaRG Cells as a Versatile Cell System Surrogate for Primary Human Hepatocytes by Tascher, Georg, Burban, Audrey, Camus, Sandrine, Plumel, Marine, Chanon, Stéphanie, Le Guevel, Remy, Shevchenko, Valery, Van Dorsselaer, Alain, Lefai, Etienne, Guguen-Guillouzo, Christiane, Bertile, Fabrice

“…Of the hepatic cell lines developed for in vitro studies of hepatic functions as alternatives to primary human hepatocytes, many have lost major liver-like…”
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