Search Results - "Leevy, W M"

ALBIRA: A small animal PET/SPECT/CT imaging system by Sánchez, F., Orero, A., Soriano, A., Correcher, C., Conde, P., González, A., Hernández, L., Moliner, L., Rodríguez-Alvarez, M. J., Vidal, L. F., Benlloch, J. M., Chapman, S. E., Leevy, W. M.

“…Purpose: The authors have developed a trimodal PET/SPECT/CT scanner for small animal imaging. The gamma ray subsystems are based on monolithic crystals coupled…”
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Multimodal optical, X-ray CT, and SPECT imaging of a mouse model of breast cancer lung metastasis by Davison, C A, Chapman, S E, Sasser, T A, Wathen, C, Diener, J, Schafer, Z T, Leevy, W M

“…Tumor heterogeneity is recognized as a major issue within clinical oncology, and the concept of personalized molecular medicine is emerging as a means to…”
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Scaled Anatomical Model Creation of Biomedical Tomographic Imaging Data and Associated Labels for Subsequent Sub-surface Laser Engraving (SSLE) of Glass Crystals by Betts, Aislinn M, McGoldrick, Matthew T, Dethlefs, Christopher R, Piotrowicz, Justin, Van Avermaete, Tony, Maki, Jeff, Gerstler, Steve, Leevy, W M

“…Biomedical imaging modalities like computed tomography (CT) and magnetic resonance (MR) provide excellent platforms for collecting three-dimensional data sets…”
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Scaled Anatomical Model Creation of Biomedical Tomographic Imaging Data and Associated Labels for Subsequent Sub-surface Laser Engraving (SSLE) of Glass Crystals by Betts, Aislinn M., McGoldrick, Matthew T., Dethlefs, Christopher R., Piotrowicz, Justin, Van Avermaete, Tony, Maki, Jeff, Gerstler, Steve, Leevy, W. M.

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Crown Ethers:  Sensors for Ions and Molecular Scaffolds for Materials and Biological Models by Gokel, George W., Leevy, W. Matthew, Weber, Michelle E.

“…Crown ethers are heterocycles that, in their simplest form, are cyclic oligomers of dioxane. The essential repeating unit of any simple crown ether is…”
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NON-INVASIVE OPTICAL IMAGING OF ISLETS TRANSPLANTED IN MICE USING NEAR INFRARED FLUORESCENT NANOPARTICLES: 1378 by Mojibian, M., Leevy, W. M., Kordyban, S., Speck, M., Kieffer, T. J.

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Optical Imaging of Bacterial Infection in Living Mice Using a Fluorescent Near-Infrared Molecular Probe by Leevy, W. Matthew, Gammon, Seth T, Jiang, Hua, Johnson, James R, Maxwell, Dustin J, Jackson, Erin N, Marquez, Manuel, Piwnica-Worms, David, Smith, Bradley D

“…An optical imaging probe was synthesized by attaching a near-infrared carbocyanine fluorophore to an affinity group containing two zinc(II) dipicolylamine…”
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Spectral Unmixing of Multicolored Bioluminescence Emitted from Heterogeneous Biological Sources by Gammon, Seth T, Leevy, W. Matthew, Gross, Shimon, Gokel, George W, Piwnica-Worms, David

“…A wide variety of bioluminescent luciferase proteins are available for use in transcriptional or biochemical reporter assays. However, spectral overlap…”
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Selective recognition of bacterial membranes by zinc(II)-coordination complexes by Leevy, W Matthew, Johnson, James R, Lakshmi, C, Morris, Joshua, Marquez, Manuel, Smith, Bradley D

“…Two fluorophore-dipicolylamine-Zn2+ conjugates are shown by epifluorescence microscopy to stain the membranes of bacterial cells in preference to mammalian…”
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Synthetic Hydraphile Channels of Appropriate Length Kill Escherichia coli by LEEVY, W. Matthew, DONATO, Gina M., FERDANI, Riccardo, GOLDMAN, William E., SCHLESINGER, Paul H., GOKEL, George W.

“…Crown ether-based synthetic cation conducting channels called hydraphiles show clear ionophoretic activity in phospholipid vesicles. These compounds are shown…”
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A synthetic, chloride-selective channel that alters chloride transport in epithelial cells by Pajewski, Robert, Garcia-Medina, Raquel, Brody, Steven L, Leevy, W Matthew, Schlesinger, Paul H, Gokel, George W

“…An Ussing chamber was used to demonstrate that synthetic amphiphilic anion transporters function as chloride transporters in mammalian airway epithelial cells…”
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NMR and ion selective electrode studies of hydraphile channels correlate with biological activity in E. coli and B. subtilis by Leevy, W Matthew, Weber, Michelle E, Schlesinger, Paul H, Gokel, George W

“…Previous sodium ion transport results obtained by NMR methods are compared with those obtained by a new ISE technique and are found to correlate well with each…”
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Synthetic Ion Channel Activity Documented by Electrophysiological Methods in Living Cells by Leevy, W. Matthew, Huettner, James E, Pajewski, Robert, Schlesinger, Paul H, Gokel, George W

“…Hydraphiles are synthetic ion channels that use crown ethers as entry portals and that span phospholipid bilayer membranes. Proton and sodium cation transport…”
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Correlation of bilayer membrane cation transport and biological activity in alkyl-substituted lariat ethers by Leevy, W Matthew, Weber, Michelle E, Gokel, Michael R, Hughes-Strange, George B, Daranciang, David D, Ferdani, Riccardo, Gokel, George W

“…Dialkyldiaza-18-crown-6 lariat ethers having twin n-octyl, n-decyl, n-dodecyl, n-tetradecyl, n-hexadecyl, 1-oxodecyl and 1-oxododecyl side arms were prepared…”
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Functional, synthetic organic chemical models of cellular ion channels by Gokel, George W, Schlesinger, Paul H, Djedovič, Natasha K, Ferdani, Riccardo, Harder, Egan C, Hu, Jiaxin, Leevy, W.Matthew, Pajewska, Jolanta, Pajewski, Robert, Weber, Michelle E

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Structure-activity relationships, kinetics, selectivity, and mechanistic studies of synthetic hydraphile channels in bacterial and mammalian cells by Leevy, W Matthew, Gammon, Seth T, Levchenko, Tatiana, Daranciang, David D, Murillo, Oscar, Torchilin, Vladimir, Piwnica-Worms, David, Huettner, James E, Gokel, George W

“…Hydraphile compounds are shown to be cytotoxic to Gram-negative and Gram-positive bacteria, yeast, and mammalian cells. Their cellular toxicity compares…”
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The influence of aromatic residues in hydraphile spacer units: assay by ion selective electrode methods and in bacteria by Meyer, Adam E., Leevy, W. Matthew, Pajewski, Robert, Suzuki, Iwao, Weber, Michelle E., Gokel, George W.

“…[Display omitted] A small library of hydraphiles has been prepared that incorporates either 1,4-phenylenedioxy or 2,6-naphthalenedioxy within the spacer…”
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