Search Results - "Leeuwenburgh, Christiaan"

Fasting or caloric restriction for Healthy Aging by Anton, Stephen, Leeuwenburgh, Christiaan

“…Aging is associated with a host of biological changes that contribute to a progressive decline in cognitive and physical function, ultimately leading to a loss…”
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Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting by Anton, Stephen D., Moehl, Keelin, Donahoo, William T., Marosi, Krisztina, Lee, Stephanie A., Mainous, Arch G., Leeuwenburgh, Christiaan, Mattson, Mark P.

“…Objective Intermittent fasting (IF) is a term used to describe a variety of eating patterns in which no or few calories are consumed for time periods that can…”
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Mitochondrial dysfunction and sarcopenia of aging: From signaling pathways to clinical trials by Marzetti, Emanuele, Calvani, Riccardo, Cesari, Matteo, Buford, Thomas W., Lorenzi, Maria, Behnke, Bradley J., Leeuwenburgh, Christiaan

“…Sarcopenia, the age-related loss of muscle mass and function, imposes a dramatic burden on individuals and society. The development of preventive and…”
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Beneficial effects of exercise on age‐related mitochondrial dysfunction and oxidative stress in skeletal muscle by Joseph, Anna‐Maria, Adhihetty, Peter J., Leeuwenburgh, Christiaan

“…Mitochondria are negatively affected by ageing leading to their inability to adapt to higher levels of oxidative stress and this ultimately contributes to the…”
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Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics by Marzetti, Emanuele, Csiszar, Anna, Dutta, Debapriya, Balagopal, Gauthami, Calvani, Riccardo, Leeuwenburgh, Christiaan

“…Advanced age is associated with a disproportionate prevalence of cardiovascular disease (CVD). Intrinsic alterations in the heart and the vasculature occurring…”
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Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction by Someya, Shinichi, Yu, Wei, Hallows, William C., Xu, Jinze, Vann, James M., Leeuwenburgh, Christiaan, Tanokura, Masaru, Denu, John M., Prolla, Tomas A.

“…Caloric restriction (CR) extends the life span and health span of a variety of species and slows the progression of age-related hearing loss (AHL), a common…”
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Fueling Inflamm-Aging through Mitochondrial Dysfunction: Mechanisms and Molecular Targets by Picca, Anna, Lezza, Angela Maria Serena, Leeuwenburgh, Christiaan, Pesce, Vito, Calvani, Riccardo, Landi, Francesco, Bernabei, Roberto, Marzetti, Emanuele

“…Among the complex determinants of aging, mitochondrial dysfunction has been in the spotlight for a long time. As the hub for many cellular functions, the…”
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Skeletal muscle autophagy and apoptosis during aging: Effects of calorie restriction and life-long exercise by Wohlgemuth, Stephanie Eva, Seo, Arnold Young, Marzetti, Emanuele, Lees, Hazel Anne, Leeuwenburgh, Christiaan

“…Sarcopenia, loss of muscle mass and function, is a common feature of aging. Oxidative damage and apoptosis are likely underlying factors. Autophagy, a process…”
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The Effects of Time Restricted Feeding on Overweight, Older Adults: A Pilot Study by Anton, Stephen D, Lee, Stephanie A, Donahoo, William T, McLaren, Christian, Manini, Todd, Leeuwenburgh, Christiaan, Pahor, Marco

“…A growing body of evidence indicates that time restricted feeding (TRF), a popular form of intermittent fasting, can activate similar biological pathways as…”
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Apoptosis in skeletal myocytes: a potential target for interventions against sarcopenia and physical frailty - a mini-review by Marzetti, Emanuele, Calvani, Riccardo, Bernabei, Roberto, Leeuwenburgh, Christiaan

“…Sarcopenia, the age-related loss of muscle mass and function, represents a relevant public health issue due to its high prevalence and detrimental…”
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The COVID-19 pandemic and physical activity by Woods, Jeffrey A., Hutchinson, Noah T., Powers, Scott K., Roberts, William O., Gomez-Cabrera, Mari Carmen, Radak, Zsolt, Berkes, Istvan, Boros, Anita, Boldogh, Istvan, Leeuwenburgh, Christiaan, Coelho-Júnior, Hélio José, Marzetti, Emanuele, Cheng, Ying, Liu, Jiankang, Durstine, J. Larry, Sun, Junzhi, Ji, Li Li

“…The SARS-CoV-2-caused COVID-19 pandemic has resulted in a devastating threat to human society in terms of health, economy, and lifestyle. Although the virus…”
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Cardiac mitochondrial bioenergetics, oxidative stress, and aging by Judge, Sharon, Leeuwenburgh, Christiaan

“…Mitochondria have been a central focus of several theories of aging as a result of their critical role in bioenergetics, oxidant production, and regulation of…”
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The contribution of mitochondrial DNA alterations to aging, cancer, and neurodegeneration by Picca, Anna, Guerra, Flora, Calvani, Riccardo, Coelho-Júnior, Hélio José, Leeuwenburgh, Christiaan, Bucci, Cecilia, Marzetti, Emanuele

“…Mitochondrial DNA (mtDNA) is as a double-stranded molecule existing in hundreds to thousands copies in cells depending on cell metabolism and exposure to…”
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Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy by Calvani, Riccardo, Joseph, Anna-Maria, Adhihetty, Peter J, Miccheli, Alfredo, Bossola, Maurizio, Leeuwenburgh, Christiaan, Bernabei, Roberto, Marzetti, Emanuele

“…Muscle loss during aging and disuse is a highly prevalent and disabling condition, but knowledge about cellular pathways mediating muscle atrophy is still…”
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Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases by Knutson, Mitchell D, Leeuwenburgh, Christiaan

“…Studies show that the plant polyphenol resveratrol can extend the life span of yeast, worms, flies, and fish. It also mitigates the metabolic dysfunction of…”
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Circulating Mitochondrial DNA at the Crossroads of Mitochondrial Dysfunction and Inflammation During Aging and Muscle Wasting Disorders by Picca, Anna, Lezza, Angela Maria Serena, Leeuwenburgh, Christiaan, Pesce, Vito, Calvani, Riccardo, Bossola, Maurizio, Manes-Gravina, Ester, Landi, Francesco, Bernabei, Roberto, Marzetti, Emanuele

“…Mitochondrial structural and functional integrity is maintained through the coordination of several processes (e.g., biogenesis, dynamics, mitophagy),…”
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The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high‐ and low‐functioning elderly individuals by Joseph, Anna‐Maria, Adhihetty, Peter J., Buford, Thomas W., Wohlgemuth, Stephanie E., Lees, Hazel A., Nguyen, Linda M.‐D., Aranda, Juan M., Sandesara, Bhanu D., Pahor, Marco, Manini, Todd M., Marzetti, Emanuele, Leeuwenburgh, Christiaan

“…Summary Age‐related loss of muscle mass and strength (sarcopenia) leads to a decline in physical function and frailty in the elderly. Among the many proposed…”
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Successful aging: Advancing the science of physical independence in older adults by Anton, Stephen D, Woods, Adam J, Ashizawa, Tetso, Barb, Diana, Buford, Thomas W, Carter, Christy S, Clark, David J, Cohen, Ronald A, Corbett, Duane B, Cruz-Almeida, Yenisel, Dotson, Vonetta, Ebner, Natalie, Efron, Philip A, Fillingim, Roger B, Foster, Thomas C, Gundermann, David M, Joseph, Anna-Maria, Karabetian, Christy, Leeuwenburgh, Christiaan, Manini, Todd M, Marsiske, Michael, Mankowski, Robert T, Mutchie, Heather L, Perri, Michael G, Ranka, Sanjay, Rashidi, Parisa, Sandesara, Bhanuprasad, Scarpace, Philip J, Sibille, Kimberly T, Solberg, Laurence M, Someya, Shinichi, Uphold, Connie, Wohlgemuth, Stephanie, Wu, Samuel Shangwu, Pahor, Marco

“…Highlights • A consensus definition is needed for the multi-faceted construct of “successful aging” to advance the development of strategies that promote…”
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Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis by Someya, Shinichi, Xu, Jinze, Kondo, Kenji, Ding, Dalian, Salvi, Richard J, Yamasoba, Tatsuya, Rabinovitch, Peter S, Weindruch, Richard, Leeuwenburgh, Christiaan, Tanokura, Masaru, Prolla, Tomas A

“…Age-related hearing loss (AHL), known as presbycusis, is a universal feature of mammalian aging and is the most common sensory disorder in the elderly…”
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Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis by Hollen, McKenzie K, Stortz, Julie A, Darden, Dijoia, Dirain, Marvin L, Nacionales, Dina C, Hawkins, Russell B, Cox, Michael C, Lopez, Maria-Cecilia, Rincon, Jaimar C, Ungaro, Ricardo, Wang, Zhongkai, Wu, Quran, Brumback, Babette, Gauthier, Marie-Pierre L, Kladde, Michael, Leeuwenburgh, Christiaan, Segal, Mark, Bihorac, Azra, Brakenridge, Scott, Moore, Frederick A, Baker, Henry V, Mohr, Alicia M, Moldawer, Lyle L, Efron, Philip A

“…Sepsis is an increasingly significant challenge throughout the world as one of the major causes of patient morbidity and mortality. Central to the host…”
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