Search Results - "Lees, W"

New IBD genetics: common pathways with other diseases by Lees, C W, Barrett, J C, Parkes, M, Satsangi, J

“…Complex disease genetics has been revolutionised in recent years by the advent of genome-wide association (GWA) studies. The chronic inflammatory bowel…”
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The impact of different DNA extraction kits and laboratories upon the assessment of human gut microbiota composition by 16S rRNA gene sequencing by Kennedy, Nicholas A, Walker, Alan W, Berry, Susan H, Duncan, Sylvia H, Farquarson, Freda M, Louis, Petra, Thomson, John M, Satsangi, Jack, Flint, Harry J, Parkhill, Julian, Lees, Charlie W, Hold, Georgina L

“…Determining bacterial community structure in fecal samples through DNA sequencing is an important facet of intestinal health research. The impact of different…”
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Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease by de Lange, Katrina M, Moutsianas, Loukas, Lee, James C, Lamb, Christopher A, Luo, Yang, Kennedy, Nicholas A, Jostins, Luke, Rice, Daniel L, Gutierrez-Achury, Javier, Ji, Sun-Gou, Heap, Graham, Nimmo, Elaine R, Edwards, Cathryn, Henderson, Paul, Mowat, Craig, Sanderson, Jeremy, Satsangi, Jack, Simmons, Alison, Wilson, David C, Tremelling, Mark, Hart, Ailsa, Mathew, Christopher G, Newman, William G, Parkes, Miles, Lees, Charlie W, Uhlig, Holm, Hawkey, Chris, Prescott, Natalie J, Ahmad, Tariq, Mansfield, John C, Anderson, Carl A, Barrett, Jeffrey C

“…Jeffrey Barrett, Carl Anderson and colleagues report the results of a large genome-wide association study of inflammatory bowel disease. They identify 25 new…”
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IBD prevalence in Lothian, Scotland, derived by capture-recapture methodology by Jones, Gareth-Rhys, Lyons, Mathew, Plevris, Nikolas, Jenkinson, Philip W, Bisset, Cathy, Burgess, Christopher, Din, Shahida, Fulforth, James, Henderson, Paul, Ho, Gwo-Tzer, Kirkwood, Kathryn, Noble, Colin, Shand, Alan G, Wilson, David C, Arnott, Ian Dr, Lees, Charlie W

“…IBD prevalence is estimated to be rising, but no detailed, recent UK data are available. The last reported prevalence estimate in the UK was 0.40% in 2003. We…”
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British Society of Gastroenterology guidance for management of inflammatory bowel disease during the COVID-19 pandemic by Kennedy, Nicholas A, Jones, Gareth-Rhys, Lamb, Christopher A, Appleby, Richard, Arnott, Ian, Beattie, R Mark, Bloom, Stuart, Brooks, Alenka J, Cooney, Rachel, Dart, Robin J, Edwards, Cathryn, Fraser, Aileen, Gaya, Daniel R, Ghosh, Subrata, Greveson, Kay, Hansen, Richard, Hart, Ailsa, Hawthorne, A Barney, Hayee, Bu'Hussain, Limdi, Jimmy K, Murray, Charles D, Parkes, Gareth C, Parkes, Miles, Patel, Kamal, Pollok, Richard C, Powell, Nick, Probert, Chris S, Raine, Tim, Sebastian, Shaji, Selinger, Christian, Smith, Philip J, Stansfield, Catherine, Younge, Lisa, Lindsay, James O, Irving, Peter M, Lees, Charlie W

“…The COVID-19 pandemic is putting unprecedented pressures on healthcare systems globally. Early insights have been made possible by rapid sharing of data from…”
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Five-year survival in 309 patients with colorectal liver metastases treated with radiofrequency ablation by Gillams, A. R., Lees, W. R.

“…There is little published long-term survival data for patients with colorectal liver metastases treated with radiofrequency ablation (RFA). We present a…”
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Comparison of resection and radiofrequency ablation for treatment of solitary colorectal liver metastases by Oshowo, A., Gillams, A., Harrison, E., Lees, W. R., Taylor, I.

“…Background: Liver resection is the treatment of choice for patients with solitary colorectal liver metastases. In recent years, however, radiofrequency…”
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Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7 by Luo, Yang, de Lange, Katrina M, Jostins, Luke, Moutsianas, Loukas, Randall, Joshua, Kennedy, Nicholas A, Lamb, Christopher A, McCarthy, Shane, Ahmad, Tariq, Edwards, Cathryn, Serra, Eva Goncalves, Hart, Ailsa, Hawkey, Chris, Mansfield, John C, Mowat, Craig, Newman, William G, Nichols, Sam, Pollard, Martin, Satsangi, Jack, Simmons, Alison, Tremelling, Mark, Uhlig, Holm, Wilson, David C, Lee, James C, Prescott, Natalie J, Lees, Charlie W, Mathew, Christopher G, Parkes, Miles, Barrett, Jeffrey C, Anderson, Carl A

“…Carl Anderson, Jeffrey Barrett and colleagues use whole-genome sequencing and imputation to explore the genetic architecture of inflammatory bowel disease…”
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Deep Learning Classification of 3.5-GHz Band Spectrograms With Applications to Spectrum Sensing by Lees, W. Max, Wunderlich, Adam, Jeavons, Peter J., Hale, Paul D., Souryal, Michael R.

“…In the United States, the Federal Communications Commission has adopted rules permitting commercial wireless networks to share spectrum with federal incumbents…”
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Local ionic transport enables selective PGM-free bipolar membrane electrode assembly by Li, Mengran, Lees, Eric W., Ju, Wen, Subramanian, Siddhartha, Yang, Kailun, Bui, Justin C., Iglesias van Montfort, Hugo-Pieter, Abdinejad, Maryam, Middelkoop, Joost, Strasser, Peter, Weber, Adam Z., Bell, Alexis T., Burdyny, Thomas

“…Bipolar membranes in electrochemical CO 2 conversion cells enable different reaction environments in the CO 2 -reduction and O 2 -evolution compartments. Under…”
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Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility by Parkes, Miles, Barrett, Jeffrey C, Prescott, Natalie J, Tremelling, Mark, Anderson, Carl A, Fisher, Sheila A, Roberts, Roland G, Nimmo, Elaine R, Cummings, Fraser R, Soars, Dianne, Drummond, Hazel, Lees, Charlie W, Khawaja, Saud A, Bagnall, Richard, Burke, Denis A, Todhunter, Catherine E, Ahmad, Tariq, Onnie, Clive M, McArdle, Wendy, Strachan, David, Bethel, Graeme, Bryan, Claire, Lewis, Cathryn M, Deloukas, Panos, Forbes, Alastair, Sanderson, Jeremy, Jewell, Derek P, Satsangi, Jack, Mansfield, John C, Cardon, Lon, Mathew, Christopher G

“…A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel…”
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The Impact of NOD2 Variants on Fecal Microbiota in Crohn's Disease and Controls Without Gastrointestinal Disease by Kennedy, Nicholas A, Lamb, Christopher A, Berry, Susan H, Walker, Alan W, Mansfield, John, Parkes, Miles, Simpkins, Rachel, Tremelling, Mark, Nutland, Sarah, Parkhill, Julian, Probert, Chris, Hold, Georgina L, Lees, Charlie W

“…Abstract Background/Aims Current models of Crohn's disease (CD) describe an inappropriate immune response to gut microbiota in genetically susceptible…”
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Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease by Ouwehand, Willem, Keniry, Andrew, Fisher, Sheila A, Jewell, Derek P, Anderson, Carl A, Prescott, Natalie J, Deloukas, Panos, Blaszczyk, Katarzyna, Mansfield, John C, Mathew, Christopher G, Watkins, Nick, Drummond, Hazel, Cummings, Fraser R, Forbes, Alastair, Barrett, Jeffrey C, Ravindrarajah, Radhi, Sanderson, Jeremy, Inouye, Mike, Hunt, Sarah, Nimmo, Elaine R, Johnson, Christopher, Bumpstead, Suzannah, Hanson, Catherine E, Lobo, Alan, Massey, Dunecan, Cardon, Lon, Ewels, Philip, Satsangi, Jack, Tremelling, Mark, Gwilliam, Rhian, Carter, Martyn, Berzuini, Carlo, Lees, Charlie W, Onnie, Clive M, Parkes, Miles, Lewis, Cathryn M

“…We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several…”
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Misalignment in rigidly coupled rotors by Lees, A.W.

“…Misalignment of multibearing rotor systems is one of the most common fault conditions yet it is still not fully understood. There are numerous (and sometimes…”
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Real-world experience with tofacitinib in ulcerative colitis: a systematic review and meta-analysis by Lucaciu, Laura A., Constantine-Cooke, Nathan, Plevris, Nikolas, Siakavellas, Spyros, Derikx, Lauranne A.A.P., Jones, Gareth-Rhys, Lees, Charles W.

“…Background and aims: Tofacitinib is a Janus kinase inhibitor (JAKi) recently approved for the treatment of moderate to severe ulcerative colitis (UC) based on…”
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Electrolytic conversion of carbon capture solutions containing carbonic anhydrase by Fink, Arthur G., Lees, Eric W., Gingras, Julie, Madore, Eric, Fradette, Sylvie, Jaffer, Shaffiq A., Goldman, Maxwell, Dvorak, David J., Berlinguette, Curtis P.

“…The electrolysis of carbon capture solutions bypasses energy-intensive CO2 recovery steps that are often required to convert CO2 into value-added products. We…”
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Effect of preoperative chemotherapy on the outcome of women with operable breast cancer by Fisher, B, Bryant, J, Wolmark, N, Mamounas, E, Brown, A, Fisher, E R, Wickerham, D L, Begovic, M, DeCillis, A, Robidoux, A, Margolese, R G, Cruz, Jr, A B, Hoehn, J L, Lees, A W, Dimitrov, N V, Bear, H D

“…To determine, in women with primary operable breast cancer, if preoperative doxorubicin (Adriamycin) and cyclophosphamide (Cytoxan; AC) therapy yields a better…”
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Systematic review: the use of thiopurines or anti‐TNF in post‐operative Crohn's disease maintenance – progress and prospects by Jones, G. R., Kennedy, N. A., Lees, C. W., Arnott, I. D., Satsangi, J.

“…Summary Background Post‐operative recurrence of Crohn's disease is an important management challenge, with 2‐year recurrence rates defined by clinical,…”
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Modeling of Treatment Outcomes with Tofacitinib Maintenance Therapy in Patients with Ulcerative Colitis: A Post Hoc Analysis of Data from the OCTAVE Clinical Program by Chiorean, Michael, Daperno, Marco, Lees, Charlie W., Bonfanti, Gianluca, Soudis, Dimitrios, Modesto, Irene, Deuring, J. Jasper, Edwards, Roger A.

“…Introduction Tofacitinib is an oral small molecule Janus kinase inhibitor for the treatment of ulcerative colitis (UC). This post hoc analysis assessed whether…”
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Diagnosis of Duct Disruption and Assessment of Pancreatic Leak with Dynamic Secretin-Stimulated MR Cholangiopancreatography by Gillams, A. R, Kurzawinski, T, Lees, W. R

“…The management of pancreatic duct disruption is complex and depends on several factors including the cause, morphology, and degree of disruption. ERCP can show…”
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