Search Results - "Lees, P"

Pharmacokinetics, pharmacodynamics and therapeutics of pradofloxacin in the dog and cat by Lees, P.

“…Pradofloxacin is a third‐generation fluoroquinolone, licensed in the EU for use in a range of indications in the dog and cat and authorized more recently in…”
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Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining by Mahaney, Brandi L, Meek, Katheryn, Lees-Miller, Susan P

“…DNA DSBs (double-strand breaks) are considered the most cytotoxic type of DNA lesion. They can be introduced by external sources such as IR (ionizing…”
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Detection and Repair of Ionizing Radiation-Induced DNA Double Strand Breaks: New Developments in Nonhomologous End Joining by Wang, Chen, PhD, Lees-Miller, Susan P., PhD

“…DNA damage can occur as a result of endogenous metabolic reactions and replication stress or from exogenous sources such as radiation therapy and chemotherapy…”
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Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy by Ye, Zu, Shi, Yin, Lees-Miller, Susan P, Tainer, John A

“…The DNA damage response (DDR) is an organized network of multiple interwoven components evolved to repair damaged DNA and maintain genome fidelity…”
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Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease by Lees-Miller, James P., Cobban, Alexander, Katsonis, Panagiotis, Bacolla, Albino, Tsutakawa, Susan E., Hammel, Michal, Meek, Katheryn, Anderson, Dave W., Lichtarge, Olivier, Tainer, John A., Lees-Miller, Susan P.

“…DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a key member of the phosphatidylinositol-3 kinase-like (PIKK) family of protein kinases with…”
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A Phase Ib, Dose-Finding Study of Multiple Doses of Remimazolam (CNS 7056) in Volunteers Undergoing Colonoscopy by Worthington, Mark T., Antonik, Laurie J., Goldwater, D. Ronald, Lees, James P., Wilhelm-Ogunbiyi, Karin, Borkett, Keith M., Mitchell, Mack C.

“…We performed the first multiple dose study of remimazolam designed to assess both the feasibility of maintaining suitable sedation during colonoscopy and…”
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The role of the P2X₇ receptor in infectious diseases by Miller, Catherine M, Boulter, Nicola R, Fuller, Stephen J, Zakrzewski, Alana M, Lees, Michael P, Saunders, Bernadette M, Wiley, James S, Smith, Nicholas C

“…ATP is an extracellular signal for the immune system, particularly during an inflammatory response. It is sensed by the P2X₇ receptor, the expression of which…”
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Dissection of DNA double-strand-break repair using novel single-molecule forceps by Wang, Jing L., Duboc, Camille, Wu, Qian, Ochi, Takashi, Liang, Shikang, Tsutakawa, Susan E., Lees-Miller, Susan P., Nadal, Marc, Tainer, John A., Blundell, Tom L., Strick, Terence R.

“…Repairing DNA double-strand breaks (DSBs) by nonhomologous end joining (NHEJ) requires multiple proteins to recognize and bind DNA ends, process them for…”
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Enhanced HIV SOSIP Envelope yields in plants through transient co-expression of peptidyl-prolyl isomerase B and calreticulin chaperones and ER targeting by Rosenberg, Yvonne J., Jiang, Xiaoming, Lees, Jonathan P., Urban, Lori A., Mao, Lingjun, Sack, Markus

“…High yield production of recombinant HIV SOSIP envelope (Env) trimers has proven elusive as numerous disulfide bonds, proteolytic cleavage and extensive…”
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ATM-Deficient Cancers Provide New Opportunities for Precision Oncology by Jette, Nicholas R, Kumar, Mehul, Radhamani, Suraj, Arthur, Greydon, Goutam, Siddhartha, Yip, Steven, Kolinsky, Michael, Williams, Gareth J, Bose, Pinaki, Lees-Miller, Susan P

“…Poly-ADP ribose polymerase (PARP) inhibitors are currently used in the treatment of several cancers carrying mutations in the breast and ovarian cancer…”
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Mre11–Rad50–Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks by Williams, Gareth J., Lees-Miller, Susan P., Tainer, John A.

“…Repair and integrity of DNA ends at breaks, replication forks and telomeres are essential for life; yet, paradoxically, these responses are, in many cases,…”
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Mechanism of efficient double-strand break repair by a long non-coding RNA by Thapar, Roopa, Wang, Jing L, Hammel, Michal, Ye, Ruiqiong, Liang, Ke, Sun, Chengcao, Hnizda, Ales, Liang, Shikang, Maw, Su S, Lee, Linda, Villarreal, Heather, Forrester, Isaac, Fang, Shujuan, Tsai, Miaw-Sheue, Blundell, Tom L, Davis, Anthony J, Lin, Chunru, Lees-Miller, Susan P, Strick, Terence R, Tainer, John A

“…Abstract Mechanistic studies in DNA repair have focused on roles of multi-protein DNA complexes, so how long non-coding RNAs (lncRNAs) regulate DNA repair is…”
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ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Olaparib by Wang, Chen, Jette, Nicholas, Moussienko, Daniel, Bebb, D. Gwyn, Lees-Miller, Susan P

“…Abstract The ataxia telangiectasia mutated (ATM) protein kinase plays a central role in the cellular response to DNA damage. Loss or inactivation of both…”
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DNA damage-induced activation of ATM and ATM-dependent signaling pathways by Kurz, Ebba U, Lees-Miller, Susan P

“…Ataxia-telangiectasia mutated (ATM) plays a key role in regulating the cellular response to ionizing radiation. Activation of ATM results in phosphorylation of…”
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Long Noncoding RNA NIHCOLE Promotes Ligation Efficiency of DNA Double-Strand Breaks in Hepatocellular Carcinoma by Unfried, Juan P, Marín-Baquero, Mikel, Rivera-Calzada, Ángel, Razquin, Nerea, Martín-Cuevas, Eva M, de Bragança, Sara, Aicart-Ramos, Clara, McCoy, Christopher, Prats-Mari, Laura, Arribas-Bosacoma, Raquel, Lee, Linda, Caruso, Stefano, Zucman-Rossi, Jessica, Sangro, Bruno, Williams, Gareth, Moreno-Herrero, Fernando, Llorca, Oscar, Lees-Miller, Susan P, Fortes, Puri

“…Long noncoding RNAs (lncRNA) are emerging as key players in cancer as parts of poorly understood molecular mechanisms. Here, we investigated lncRNAs that play…”
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Combined poly-ADP ribose polymerase and ataxia-telangiectasia mutated/Rad3-related inhibition targets ataxia-telangiectasia mutated-deficient lung cancer cells by Jette, Nicholas R., Radhamani, Suraj, Arthur, Greydon, Ye, Ruiqiong, Goutam, Siddhartha, Bolyos, Anthony, Petersen, Lars F., Bose, Pinaki, Bebb, D. Gwyn, Lees-Miller, Susan P.

“…Background Up to 40% of lung adenocarcinoma have been reported to lack ataxia-telangiectasia mutated (ATM) protein expression. We asked whether ATM-deficient…”
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An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex by Hammel, Michal, Yu, Yaping, Radhakrishnan, Sarvan K., Chokshi, Chirayu, Tsai, Miaw-Sheue, Matsumoto, Yoshihiro, Kuzdovich, Monica, Remesh, Soumya G., Fang, Shujuan, Tomkinson, Alan E., Lees-Miller, Susan P., Tainer, John A.

“…DNA double-strand break (DSB) repair by non-homologous end joining (NHEJ) in human cells is initiated by Ku heterodimer binding to a DSB, followed by…”
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Author Correction: Automating data analysis for hydrogen/deuterium exchange mass spectrometry using data-independent acquisition methodology by Filandr, Frantisek, Sarpe, Vladimir, Raval, Shaunak, Crowder, D. Alex, Khan, Morgan F., Douglas, Pauline, Coales, Stephen, Viner, Rosa, Syed, Aleem, Tainer, John A., Lees-Miller, Susan P., Schriemer, David C.

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Automating data analysis for hydrogen/deuterium exchange mass spectrometry using data-independent acquisition methodology by Filandr, Frantisek, Sarpe, Vladimir, Raval, Shaunak, Crowder, D. Alex, Khan, Morgan F., Douglas, Pauline, Coales, Stephen, Viner, Rosa, Syed, Aleem, Tainer, John A., Lees-Miller, Susan P., Schriemer, David C.

“…We present a hydrogen/deuterium exchange workflow coupled to tandem mass spectrometry (HX-MS 2 ) that supports the acquisition of peptide fragment ions…”
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Activity of florfenicol for Actinobacillus pleuropneumoniae and Pasteurella multocida using standardised versus non-standardised methodology by Dorey, L., Hobson, S., Lees, P.

“…•Pasteurella multocida and Actinobacillus pleuropneumoniae are bacterial pathogens of pigs.•The pharmacodynamics of florfenicol for P. multocida and A…”
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