Search Results - "Lees, N. P."

Long-term results of the antegrade continent enema procedure for constipation in adults by Lees, N. P., Hodson, P., Hill, J., Pearson, R. C., MacLennan, I.

“…Objective  The aim of this study was to evaluate the long‐term results of the Antegrade Continent Enema (ACE) procedure for treating severe constipation in…”
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A prospective audit of early stoma complications in colorectal cancer treatment throughout the Greater Manchester and Cheshire colorectal cancer network by Parmar, K. L., Zammit, M., Smith, A., Kenyon, D., Lees, N. P.

“…Aim  The study aimed to identify the incidence of early stoma problems after surgery for colorectal cancer to identify predisposing factors and to assess the…”
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Dietary variables associated with DNA N7-methylguanine levels and O6-alkylguanine DNA-alkyltransferase activity in human colorectal mucosa by Billson, H. A., Harrison, K. L., Lees, N. P., Hall, C. N., Margison, G. P., Povey, A. C.

“…Components of human diets may influence the incidence of colorectal adenomas, by modifying exposure or susceptibility to DNA-damaging alkylating agents. To…”
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Recurrent intestinal fistulation after porcine acellular dermal matrix reinforcement in enteric fistula takedown and simultaneous abdominal wall reconstruction by Kalaiselvan, R., Carlson, G. L., Hayes, S., Lees, N. P., Anderson, I. D., Slade, D. A. J.

“…Purpose Porcine acellular dermal matrix (PADM) has been promoted as a suitable material for the reinforcement of the abdominal wall in Ventral Hernia Working…”
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Development and Application of a Sensitive and Rapid Immunoassay for the Quantitation of N7-Methyldeoxyguanosine in DNA Samples by Harrison, Kathryn L, Wood, Michelle, Lees, Nicholas P, Hall, C. Nick, Margison, Geoffery P, Povey, Andrew C

“…N7-Methyldeoxyguanosine (N7-MedG) in DNA is a biomarker of exposure to environmental and endogenous methylating agents and may be of use in epidemiological…”
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Dietary variables associated with DNA N7-methylguanine levels and O 6-alkylguanine DNA-alkyltransferase activity in human colorectal mucosa by Billson, H. A., Harrison, K. L., Lees, N. P., Hall, C. N., Margison, G. P., Povey, A. C.

“…Components of human diets may influence the incidence of colorectal adenomas, by modifying exposure or susceptibility to DNA-damaging alkylating agents. To…”
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Reduced MGMT activity in human colorectal adenomas is associated with K-ras GC→AT transition mutations in a population exposed to methylating agents by Lees, Nicholas P., Harrison, Kathryn L., Hall, C. Nick, Margison, Geoffrey P., Povey, Andrew C.

“…There is increasing evidence to suggest that O6-alkyl guanine DNA-alkyltransferase (MGMT) activity provides protection against alkylating agent induced…”
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Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum by Lees, N P, Harrison, K L, Hill, E, Hall, C N, Margison, G P, Povey, A C

“…In a systematic study of O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum, tumours were found to occur in regions of low activity…”
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Longitudinal variation in O6-alkylguanine DNA-alkyltransferase activity in the human colon and rectum by LEES, N. P, HARRISON, K. L, HILL, E, HALL, C. N, MARGISON, G. P, POVEY, A. C

“…In a systematic study of O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum, tumours were found to occur in regions of low activity…”
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Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS) Society Recommendations: Part 1—Preoperative: Diagnosis, Rapid Assessment and Optimization by Peden, Carol J., Aggarwal, Geeta, Aitken, Robert J., Anderson, Iain D., Bang Foss, Nicolai, Cooper, Zara, Dhesi, Jugdeep K., French, W. Brenton, Grant, Michael C., Hammarqvist, Folke, Hare, Sarah P., Havens, Joaquim M., Holena, Daniel N., Hübner, Martin, Kim, Jeniffer S., Lees, Nicholas P., Ljungqvist, Olle, Lobo, Dileep N., Mohseni, Shahin, Ordoñez, Carlos A., Quiney, Nial, Urman, Richard D., Wick, Elizabeth, Wu, Christopher L., Young-Fadok, Tonia, Scott, Michael

“…Background Enhanced Recovery After Surgery (ERAS) protocols reduce length of stay, complications and costs for a large number of elective surgical procedures…”
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Coordinating Perioperative Care for the ‘High Risk’ General Surgical Patient Using Risk Prediction Scoring by Hafiz, S, Lees, Np

“…Identifying ‘high risk’ (>5% mortality score) emergency general surgical patients early, allows appropriate perioperative care to be allocated by securing…”
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A prospective audit of early stoma complications in colorectal cancer treatment throughout the Greater Manchester and Cheshire colorectal cancer network: Early stoma complications in colorectal cancer by Parmar, K. L., Zammit, M., Smith, A., Kenyon, D., Lees, N. P.

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Consensus Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS®) Society Recommendations Part 2—Emergency Laparotomy: Intra- and Postoperative Care by Scott, Michael J., Aggarwal, Geeta, Aitken, Robert J., Anderson, Iain D., Balfour, Angie, Foss, Nicolai Bang, Cooper, Zara, Dhesi, Jugdeep K., French, W. Brenton, Grant, Michael C., Hammarqvist, Folke, Hare, Sarah P., Havens, Joaquim M., Holena, Daniel N., Hübner, Martin, Johnston, Carolyn, Kim, Jeniffer S., Lees, Nicholas P., Ljungqvist, Olle, Lobo, Dileep N., Mohseni, Shahin, Ordoñez, Carlos A., Quiney, Nial, Sharoky, Catherine, Urman, Richard D., Wick, Elizabeth, Wu, Christopher L., Young-Fadok, Tonia, Peden, Carol J.

“…Background This is Part 2 of the first consensus guidelines for optimal care of patients undergoing emergency laparotomy (EL) using an Enhanced Recovery After…”
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Enhanced Recovery After Surgery (ERAS®) Society Consensus Guidelines for Emergency Laparotomy Part 3: Organizational Aspects and General Considerations for Management of the Emergency Laparotomy Patient by Peden, Carol J., Aggarwal, Geeta, Aitken, Robert J., Anderson, Iain D., Balfour, Angie, Foss, Nicolai Bang, Cooper, Zara, Dhesi, Jugdeep K., French, W. Brenton, Grant, Michael C., Hammarqvist, Folke, Hare, Sarah P., Havens, Joaquim M., Holena, Daniel N., Hübner, Martin, Johnston, Carolyn, Kim, Jeniffer S., Lees, Nicholas P., Ljungqvist, Olle, Lobo, Dileep N., Mohseni, Shahin, Ordoñez, Carlos A., Quiney, Nial, Sharoky, Catherine, Urman, Richard D., Wick, Elizabeth, Wu, Christopher L., Young-Fadok, Tonia, Scott, Michael J.

“…Background This is Part 3 of the first consensus guidelines for optimal care of patients undergoing emergency laparotomy using an enhanced recovery after…”
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Human colorectal mucosal O6-alkylguanine DNA-alkyltransferase activity and DNA-N7-methylguanine levels in colorectal adenoma cases and matched referents by Lees, N P, Harrison, K L, Hall, C N, Margison, G P, Povey, A C

“…Background and aims:O6-alkylguanine DNA-alkyltransferase (MGMT) provides protection against alkylating agent-induced GC→AT transition mutations. Such mutations…”
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Human colorectal mucosal O super(6)-alkylguanine DNA-alkyltransferase activity and DNA-N7-methylguanine levels in colorectal adenoma cases and matched referents by Lees, N P, Harrison, K L, Hall, C N, Margison, G P, Povey, A C

“…BACKGROUND: and aims: O super(6)-alkylguanine DNA-alkyltransferase (MGMT) provides protection against alkylating agent-induced GC arrow right AT transition…”
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Human colorectal mucosal O6-alkylguanine DNA-alkyltransferase activity and DNA-N7-methylguanine levels in colorectal adenoma cases and matched rererents. Commentary by GRADY, William M, ULRICH, Cornelia M, LEES, N. P, HARRISON, K. L, HALL, C. N, MARGISON, G. P, POVEY, A. C

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Reduced MGMT activity in human colorectal adenomas is associated with K-ras GC arrow right AT transition mutations in a population exposed to methylating agents by Lees, N P, Harrison, K L, Hall, C N, Margison, G P, Povey, A C

“…There is increasing evidence to suggest that O super(6)-alkyl guanine DNA-alkyltransferase (MGMT) activity provides protection against alkylating agent induced…”
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Longitudinal variation in O super(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum by Lees, N P, Harrison, K L, Hill, E, Hall, C N, Margison, G P, Povey, A C

“…In a systematic study of O super(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum, tumours were found to occur in regions of low…”
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DNA alkylation and repair in the large bowel: animal and human studies by Povey, Andrew C, Badawi, Alaa F, Cooper, Donald P, Hall, C Nicholas, Harrison, Kathryn L, Jackson, Peta E, Lees, Nicholas P, O'Connor, Peter J, Margison, Geoffrey P

“…O6-methylguanine (O6-MeG), a procarcinogenic DNA adduct that arises from exposure to methylating agents, has been detected in human colorectal DNA at levels…”
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