Search Results - "Lees, J. G."

CDtool—an integrated software package for circular dichroism spectroscopic data processing, analysis, and archiving by Lees, J.G., Smith, B.R., Wien, F., Miles, A.J., Wallace, B.A.

“…CDtool is a software package written to facilitate circular dichroism (CD) spectroscopic studies on both conventional lab-based instruments and synchrotron…”
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The actin-associating protein Tm5NM1 blocks mesenchymal motility without transition to amoeboid motility by Lees, J G, Bach, C T T, Bradbury, P, Paul, A, Gunning, P W, O'Neill, G M

“…Cell migration is an integral component of metastatic disease. The ability of cells to transit between mesenchymal and amoeboid modes of migration has…”
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cath-resolve-hits: a new tool that resolves domain matches suspiciously quickly by Lewis, T E, Sillitoe, I, Lees, J G

“…Abstract Motivation Many bioinformatics areas require us to assign domain matches onto stretches of a query protein. Starting with a set of candidate matches,…”
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Pharmacology of AMPA/kainate receptor ligands and their therapeutic potential in neurological and psychiatric disorders by LEES, G. J

“…It has been postulated, consistent with the ubiquitous presence of glutamatergic neurons in the brain, that defects in glutamatergic neurotransmission are…”
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Analyses of circular dichroism spectra of membrane proteins by Wallace, B.A., Lees, J.G., Orry, A.J.W., Lobley, A., Janes, Robert W.

“…Circular dichroism (CD) spectroscopy is a valuable technique for the determination of protein secondary structures. Many linear and nonlinear algorithms have…”
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VUV irradiation effects on proteins in high-flux synchrotron radiation circular dichroism spectroscopy by Wien, F, Miles, A J, Lees, J G, Vrønning Hoffmann, S, Wallace, B A

“…Synchrotron radiation circular dichroism (SRCD) spectroscopy is emerging as an important new tool in structural molecular biology. Previously we had shown that…”
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Growth of Gold Nanoparticle Films Driven by the Coalescence of Particle-Stabilized Emulsion Drops by Binks, B. P, Clint, J. H, Fletcher, P. D. I, Lees, T. J. G, Taylor, P

“…We have investigated the mechanism of the spontaneous growth of a gold nanoparticle film on a container wall when an aqueous dispersion of gold nanoparticles…”
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Contributory mechanisms in the causation of neurodegenerative disorders by Lees, G J

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SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammals by Lam, S. D., Bordin, N., Waman, V. P., Scholes, H. M., Ashford, P., Sen, N., van Dorp, L., Rauer, C., Dawson, N. L., Pang, C. S. M., Abbasian, M., Sillitoe, I., Edwards, S. J. L., Fraternali, F., Lees, J. G., Santini, J. M., Orengo, C. A.

“…SARS-CoV-2 has a zoonotic origin and was transmitted to humans via an undetermined intermediate host, leading to infections in humans and other mammals. To…”
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The possible contribution of microglia and macrophages to delayed neuronal death after ischemia by Lees, G J

“…Macrophages have long been known to be involved in cytotoxic actions in many tissues in the body following infection. Knowledge of the post-injury actions of…”
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Simulated Electrocortical Activity at Microscopic, Mesoscopic, and Global Scales by WRIGHT, J. J, RENNIE, C. J, LEES, G. J, ROBINSON, P. A, BOURKE, P. D, CHAPMAN, C. L, GORDON, E, ROWE, D. L

“…Simulation of electrocortical activity requires (a) determination of the most crucial features to be modelled, (b) specification of state equations with…”
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Nitric oxide generators produce accumulation of chelatable zinc in hippocampal neuronal perikarya by Cuajungco, Math P, Lees, Gordon J

“…While zinc is essential for health, it has also been implicated in the neuropathology of several disease states such as Alzheimer's disease, epilepsy and…”
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Effect of metal chelating agents on the direct and seizure-related neuronal death induced by zinc and kainic acid by Lees, G.J, Cuajungco, M.P, Leong, W

“…The ability of metal chelating agents to affect seizure-induced neuronal death caused by intra-amygdaloid injections of kainic acid was investigated. N, N, N′,…”
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Inhibition of sodium-potassium-ATPase: a potentially ubiquitous mechanism contributing to central nervous system neuropathology by Lees, G J

“…Direct and indirect evidence suggests that Na+/K(+)-ATPase activity is reduced or insufficient to maintain ionic balances during and immediately after episodes…”
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Influence of ketamine on the neuronal death caused by NMDA in the rat hippocampus by Lees, G.J.

“…The protection provided by ketamine against the neuronal cytotoxicity of NMDA was investigated and compared with that provided by dizocilpine (MK 801). A…”
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Brain lesions induced by specific and non-specific inhibitors of sodium-potassium ATPase by Lees, G J, Leong, W

“…The cytotoxicity in the brain of potent selective and non-selective inhibitors of Na+/K+ ATPase has been assessed. Following injection of cardiac glycosides…”
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Systematic computational prediction of protein interaction networks by Lees, J G, Heriche, J K, Morilla, I, Ranea, J A, Orengo, C A

“…Determining the network of physical protein associations is an important first step in developing mechanistic evidence for elucidating biological pathways…”
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Diverse effects of metal chelating agents on the neuronal cytotoxicity of zinc in the hippocampus by Cuajungco, Math P, Lees, Gordon J

“…Abnormal metabolism of metal ions such as zinc may contribute to neuropathology. Complexing zinc could reduce this pathology. Thus, to examine the…”
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The sodium-potassium ATPase inhibitor ouabain is neurotoxic in the rat substantia nigra and striatum by Lees, G.J., Leong, W.

“…Injection of ouabain, a potent and selective inhibitor of Na +/K + ATPase, into the rat striatum and substantia nigra caused a selective neuronal loss in up to…”
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The neurotoxicity of ouabain, a sodium-potassium ATPase inhibitor, in the rat hippocampus by Lees, G J, Lehmann, A, Sandberg, M, Hamberger, A

“…Intrahippocampal injection of 1 nmol ouabain, a sodium/potassium (Na+,K(+)-)ATPase inhibitor, produced a necrotic lesion within 4 days, characterised by a…”
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