Search Results - "Lees, Charlie W."

Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease by de Lange, Katrina M, Moutsianas, Loukas, Lee, James C, Lamb, Christopher A, Luo, Yang, Kennedy, Nicholas A, Jostins, Luke, Rice, Daniel L, Gutierrez-Achury, Javier, Ji, Sun-Gou, Heap, Graham, Nimmo, Elaine R, Edwards, Cathryn, Henderson, Paul, Mowat, Craig, Sanderson, Jeremy, Satsangi, Jack, Simmons, Alison, Wilson, David C, Tremelling, Mark, Hart, Ailsa, Mathew, Christopher G, Newman, William G, Parkes, Miles, Lees, Charlie W, Uhlig, Holm, Hawkey, Chris, Prescott, Natalie J, Ahmad, Tariq, Mansfield, John C, Anderson, Carl A, Barrett, Jeffrey C

“…Jeffrey Barrett, Carl Anderson and colleagues report the results of a large genome-wide association study of inflammatory bowel disease. They identify 25 new…”
Get full text

IBD prevalence in Lothian, Scotland, derived by capture-recapture methodology by Jones, Gareth-Rhys, Lyons, Mathew, Plevris, Nikolas, Jenkinson, Philip W, Bisset, Cathy, Burgess, Christopher, Din, Shahida, Fulforth, James, Henderson, Paul, Ho, Gwo-Tzer, Kirkwood, Kathryn, Noble, Colin, Shand, Alan G, Wilson, David C, Arnott, Ian Dr, Lees, Charlie W

“…IBD prevalence is estimated to be rising, but no detailed, recent UK data are available. The last reported prevalence estimate in the UK was 0.40% in 2003. We…”
Get more information

British Society of Gastroenterology guidance for management of inflammatory bowel disease during the COVID-19 pandemic by Kennedy, Nicholas A, Jones, Gareth-Rhys, Lamb, Christopher A, Appleby, Richard, Arnott, Ian, Beattie, R Mark, Bloom, Stuart, Brooks, Alenka J, Cooney, Rachel, Dart, Robin J, Edwards, Cathryn, Fraser, Aileen, Gaya, Daniel R, Ghosh, Subrata, Greveson, Kay, Hansen, Richard, Hart, Ailsa, Hawthorne, A Barney, Hayee, Bu'Hussain, Limdi, Jimmy K, Murray, Charles D, Parkes, Gareth C, Parkes, Miles, Patel, Kamal, Pollok, Richard C, Powell, Nick, Probert, Chris S, Raine, Tim, Sebastian, Shaji, Selinger, Christian, Smith, Philip J, Stansfield, Catherine, Younge, Lisa, Lindsay, James O, Irving, Peter M, Lees, Charlie W

“…The COVID-19 pandemic is putting unprecedented pressures on healthcare systems globally. Early insights have been made possible by rapid sharing of data from…”
Get more information

The impact of different DNA extraction kits and laboratories upon the assessment of human gut microbiota composition by 16S rRNA gene sequencing by Kennedy, Nicholas A, Walker, Alan W, Berry, Susan H, Duncan, Sylvia H, Farquarson, Freda M, Louis, Petra, Thomson, John M, Satsangi, Jack, Flint, Harry J, Parkhill, Julian, Lees, Charlie W, Hold, Georgina L

“…Determining bacterial community structure in fecal samples through DNA sequencing is an important facet of intestinal health research. The impact of different…”
Get full text

Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7 by Luo, Yang, de Lange, Katrina M, Jostins, Luke, Moutsianas, Loukas, Randall, Joshua, Kennedy, Nicholas A, Lamb, Christopher A, McCarthy, Shane, Ahmad, Tariq, Edwards, Cathryn, Serra, Eva Goncalves, Hart, Ailsa, Hawkey, Chris, Mansfield, John C, Mowat, Craig, Newman, William G, Nichols, Sam, Pollard, Martin, Satsangi, Jack, Simmons, Alison, Tremelling, Mark, Uhlig, Holm, Wilson, David C, Lee, James C, Prescott, Natalie J, Lees, Charlie W, Mathew, Christopher G, Parkes, Miles, Barrett, Jeffrey C, Anderson, Carl A

“…Carl Anderson, Jeffrey Barrett and colleagues use whole-genome sequencing and imputation to explore the genetic architecture of inflammatory bowel disease…”
Get full text

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility by Parkes, Miles, Barrett, Jeffrey C, Prescott, Natalie J, Tremelling, Mark, Anderson, Carl A, Fisher, Sheila A, Roberts, Roland G, Nimmo, Elaine R, Cummings, Fraser R, Soars, Dianne, Drummond, Hazel, Lees, Charlie W, Khawaja, Saud A, Bagnall, Richard, Burke, Denis A, Todhunter, Catherine E, Ahmad, Tariq, Onnie, Clive M, McArdle, Wendy, Strachan, David, Bethel, Graeme, Bryan, Claire, Lewis, Cathryn M, Deloukas, Panos, Forbes, Alastair, Sanderson, Jeremy, Jewell, Derek P, Satsangi, Jack, Mansfield, John C, Cardon, Lon, Mathew, Christopher G

“…A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel…”
Get full text

The Impact of NOD2 Variants on Fecal Microbiota in Crohn's Disease and Controls Without Gastrointestinal Disease by Kennedy, Nicholas A, Lamb, Christopher A, Berry, Susan H, Walker, Alan W, Mansfield, John, Parkes, Miles, Simpkins, Rachel, Tremelling, Mark, Nutland, Sarah, Parkhill, Julian, Probert, Chris, Hold, Georgina L, Lees, Charlie W

“…Abstract Background/Aims Current models of Crohn's disease (CD) describe an inappropriate immune response to gut microbiota in genetically susceptible…”
Get full text

Modeling of Treatment Outcomes with Tofacitinib Maintenance Therapy in Patients with Ulcerative Colitis: A Post Hoc Analysis of Data from the OCTAVE Clinical Program by Chiorean, Michael, Daperno, Marco, Lees, Charlie W., Bonfanti, Gianluca, Soudis, Dimitrios, Modesto, Irene, Deuring, J. Jasper, Edwards, Roger A.

“…Introduction Tofacitinib is an oral small molecule Janus kinase inhibitor for the treatment of ulcerative colitis (UC). This post hoc analysis assessed whether…”
Get full text

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease by Ouwehand, Willem, Keniry, Andrew, Fisher, Sheila A, Jewell, Derek P, Anderson, Carl A, Prescott, Natalie J, Deloukas, Panos, Blaszczyk, Katarzyna, Mansfield, John C, Mathew, Christopher G, Watkins, Nick, Drummond, Hazel, Cummings, Fraser R, Forbes, Alastair, Barrett, Jeffrey C, Ravindrarajah, Radhi, Sanderson, Jeremy, Inouye, Mike, Hunt, Sarah, Nimmo, Elaine R, Johnson, Christopher, Bumpstead, Suzannah, Hanson, Catherine E, Lobo, Alan, Massey, Dunecan, Cardon, Lon, Ewels, Philip, Satsangi, Jack, Tremelling, Mark, Gwilliam, Rhian, Carter, Martyn, Berzuini, Carlo, Lees, Charlie W, Onnie, Clive M, Parkes, Miles, Lewis, Cathryn M

“…We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several…”
Get full text

Disease Monitoring in Inflammatory Bowel Disease: Evolving Principles and Possibilities by Plevris, Nikolas, Lees, Charlie W.

“…Inflammatory bowel disease is a progressive and debilitating condition. Early and effective treatment using a treat-to-target approach is key to improving…”
Get full text

Non-serious adverse events in patients with ulcerative colitis receiving etrasimod: an analysis of the phase II OASIS and phase III ELEVATE UC 52 and ELEVATE UC 12 clinical trials by Lees, Charlie W., Torres, Joana, Leung, Yvette, Vermeire, Séverine, Fellmann, Marc, Modesto, Irene, McDonnell, Aoibhinn, Lazin, Krisztina, Keating, Michael, Goetsch, Martina, Wu, Joseph, Loftus, Edward V.

“…Background: Etrasimod is an oral, once-daily (QD), selective sphingosine 1-phosphate (S1P) 1,4,5 receptor modulator for the treatment of moderately to severely…”
Get full text

Innovation in Inflammatory Bowel Disease Care During the COVID-19 Pandemic: Results of a Global Telemedicine Survey by the International Organization for the Study of Inflammatory Bowel Disease by Lees, Charlie W., Regueiro, Miguel, Mahadevan, Uma

Get full text

Long-term outcomes and predictors of vedolizumab persistence in ulcerative colitis by Gros, Beatriz, Ross, Hannah, Nwabueze, Maureen, Constantine-Cooke, Nathan, Derikx, Lauranne A A P, Lyons, Mathew, O'Hare, Claire, Noble, Colin, Arnott, Ian D, Jones, Gareth-Rhys, Lees, Charlie W, Plevris, Nikolas

“…Long-term vedolizumab (VDZ) outcomes in real-world cohorts have been largely limited to 1-year follow-up, with few bio-naïve patients or objective markers of…”
Get full text

Bilateral lower limb weakness in acute severe ulcerative colitis by Lynch, Ruairi W, MB, Soane, Timothy, PhD, Gibson, Rod, MB, Pal, Suvankar, MD, Lees, Charlie W, Dr

“…An obese 49-year-old man with no medical history of note presented in August, 2014, with a 5-week history of bloody diarrhoea, anorexia, and unintentional…”
Get full text

Prediction of early clinical response in patients receiving tofacitinib in the OCTAVE Induction 1 and 2 studies by Lees, Charlie W., Deuring, J. Jasper, Chiorean, Michael, Daperno, Marco, Bonfanti, Gianluca, Germino, Rebecca, Brown, Pritha Bhadra, Modesto, Irene, Edwards, Roger A.

“…Introduction: Tofacitinib is an oral, small molecule Janus kinase inhibitor for the treatment of ulcerative colitis (UC). Outcome prediction based on early…”
Get full text

Environmental stimuli and gut inflammation via dysbiosis in mouse and man by Lees, Charlie W.

“…A new study sheds further light on the interplay between environmental stimuli, the gut microbiota and intestinal inflammation. Identification of modifiable…”
Get full text

Infliximab is associated with attenuated immunogenicity to BNT162b2 and ChAdOx1 nCoV-19 SARS-CoV-2 vaccines in patients with IBD by Kennedy, Nicholas A, Lin, Simeng, Goodhand, James R, Chanchlani, Neil, Hamilton, Benjamin, Bewshea, Claire, Nice, Rachel, Chee, Desmond, Cummings, Jr Fraser, Fraser, Aileen, Irving, Peter M, Kamperidis, Nikolaos, Kok, Klaartje B, Lamb, Christopher Andrew, Macdonald, Jonathan, Mehta, Shameer, Pollok, Richard Cg, Raine, Tim, Smith, Philip J, Verma, Ajay Mark, Jochum, Simon, McDonald, Timothy J, Sebastian, Shaji, Lees, Charlie W, Powell, Nick, Ahmad, Tariq

“…Delayed second dose SARS-CoV-2 vaccination trades maximal effectiveness for a lower level of immunity across more of the population. We investigated whether…”
Get more information

COVID-19 and IBD drugs: should we change anything at the moment? by Lees, Charlie W, Irving, Peter M, Beaugerie, Laurent

Get more information

Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways by Lees, Charlie W, Zacharias, William J, Tremelling, Mark, Noble, Colin L, Nimmo, Elaine R, Tenesa, Albert, Cornelius, Jennine, Torkvist, Leif, Kao, John, Farrington, Susan, Drummond, Hazel E, Ho, Gwo-Tzer, Arnott, Ian D R, Appelman, Henry D, Diehl, Lauri, Campbell, Harry, Dunlop, Malcolm G, Parkes, Miles, Howie, Sarah E M, Gumucio, Deborah L, Satsangi, Jack

“…Ulcerative colitis (UC) and Crohn's disease (CD) are polygenic chronic inflammatory bowel diseases (IBD) of high prevalence that are associated with…”
Get full text

Association Between Level of Fecal Calprotectin and Progression of Crohn's Disease by Kennedy, Nicholas A., Jones, Gareth-Rhys, Plevris, Nikolas, Patenden, Rebecca, Arnott, Ian D., Lees, Charlie W.

“…Mucosal healing is associated with improved outcomes in patients with Crohn’s disease (CD), but assessment typically requires ileocolonoscopy. Calprotectin can…”
Get full text