Search Results - "Leers, M. P. G."

Activated macrophages containing tumor marker in colon carcinoma: immunohistochemical proof of a concept by Faber, T. J. E., Japink, D., Leers, M. P. G., Sosef, M. N., von Meyenfeldt, M. F., Nap, M.

“…The presence of carcinoembryonic antigen (CEA)-containing activated macrophages has been demonstrated in peripheral blood from patients with colorectal…”
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Elevated apoptosis-associated cytokeratin 18 fragments (CK18Asp386) in serum of patients with chronic liver diseases indicate hepatic and biliary inflammation by Yagmur, E., Trautwein, C., Leers, M.P.G., Gressner, A.M., Tacke, F.

“…During apoptosis, intermediate filament protein cytokeratin 18 (CK18) is cleaved by caspases at Asp396 which can be specifically detected by the monoclonal…”
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The value of the Thomas-plot in the diagnostic work up of anemic patients referred by general practitioners by LEERS, M. P. G., KEUREN, J. F. W., OOSTERHUIS, W. P.

“…Summary In patients with inflammatory conditions, diagnosing classic iron deficiency or anemia of chronic disease is challenging. In this study, we assessed…”
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Performance evaluation of the Abbott CELL-DYN Ruby and the Sysmex XT-2000i haematology analysers by LEERS, M. P. G., GOERTZ, H., FELLER, A., HOFFMANN, J. J. M. L.

“…Summary Two mid‐range haematology analysers (Abbott CELL‐DYN Ruby and Sysmex XT‐2000i) were evaluated to determine their analytical performance and workflow…”
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An immunohistochemical study of the clearance of apoptotic cellular fragments by Leers, M P G, Björklund, V, Björklund, B, Jörnvall, H, Nap, M

“…We investigated the distribution and fate of apoptotic bodies during human development and in the adult, using an antibody (M30) that recognizes a neo-epitope…”
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Multiparameter flow cytometry as a tool for the detection of micrometastatic tumour cells in the sentinel lymph node procedure of patients with breast cancer by Leers, M P G, Schoffelen, R H M G, Hoop, J G M, Theunissen, P H M H, Oosterhuis, J W A, vd Bijl, H, Rahmy, A, Tan, W, Nap, M

“…Aim: To investigate whether multiparameter flow cytometry (MP-FCM) can be used for the detection of micrometastasis in sentinel lymph nodes (SLNs) in breast…”
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Determination of threshold values for determining the size of the fraction of steroid hormone receptor–positive tumor cells in paraffin‐embedded breast carcinomas by Leers, M. P. G., Hoop, J. G. M., van Beers, M., van Rodijnen, N., Pannebakker, M., Nap, M.

“…Background For 4 years we used a multiparameter DNA flow cytometric (MP‐FCM) technique to assess steroid hormone receptor expression in the diagnostic workup…”
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Multiparameter flow cytometry in the diagnosis of a gynaecologic double tumor: a case report by MERTENS, H. J. M. M, NAP, M, LEERS, M. P. G, SALEMANS, T. H. B

“…An uncommon clinical presentation of metastatic tumor will often lead to additional diagnostic examinations. The patient of the present study was known to have…”
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Severe Ankyrin-R deficiency results in impaired surface retention and lysosomal degradation of RhAG in human erythroblasts by Satchwell, Timothy J, Bell, Amanda J, Hawley, Bethan R, Pellegrin, Stephanie, Mordue, Kathryn E, van Deursen, Cees Th B M, Braak, Nicole Heitink-Ter, Huls, Gerwin, Leers, Mathie P G, Overwater, Eline, Tamminga, Rienk Y J, van der Zwaag, Bert, Fermo, Elisa, Bianchi, Paola, van Wijk, Richard, Toye, Ashley M

“…Ankyrin-R provides a key link between band 3 and the spectrin cytoskeleton that helps to maintain the highly specialized erythrocyte biconcave shape. Ankyrin…”
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Immunocytochemical detection and mapping of a cytokeratin 18 neo-epitope exposed during early apoptosis by Leers, Mathie P. G., Kölgen, Wendy, Björklund, Viveka, Bergman, Tomas, Tribbick, Gordon, Persson, Bengt, Björklund, Peter, Ramaekers, Frans C. S., Björklund, Bertil, Nap, Marius, Jörnvall, Hans, Schutte, Bert

“…A neo‐epitope in cytokeratin 18 (CK18) that becomes available at an early caspase cleavage event during apoptosis and is not detectable in vital epithelial…”
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The pro- and anticoagulant role of blood-borne phagocytes in patients with acute coronary syndrome by Leers, Math P G, Keuren, Jeffrey F W, Frissen, Mick E P W, Huts, Mark, Kragten, Johannes A, Jie, Kon-Siong G

“…This study was performed to gain further insight in pro- and anticoagulant characteristics of leukocytes in acute coronary syndrome (ACS). For this purpose,…”
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E-cadherin and calretinin: a useful combination of immunochemical markers for differentiation between mesothelioma and metastatic adenocarcinoma by LEERS, M. P. G, AARTS, M. M. J, THEUNISSEN, P. H. M. H

“…Aims: To assess the diagnostic accuracy of combinations of antibodies in the differential diagnosis of metastatic carcinomas and mesotheliomas in pleural…”
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Reduced E-cadherin expression is associated with increased lymph node metastasis and unfavorable prognosis in non-small cell lung cancer by SULZER, M. A, LEERS, M. P. G, VAN NOORD, J. A, BOLLEN, E. C. M, THEUNISSEN, P. H. M. H

“…E-cadherin is a calcium-dependent, epithelial cell adhesion molecule whose reduced expression has been associated with tumor dedifferentiation and increased…”
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The expression of beta-catenin in non-small-cell lung cancer: a clinicopathological study by Retera, J M, Leers, M P, Sulzer, M A, Theunissen, P H

“…AIMS: To investigate the expression of beta-catenin in non-small-cell lung cancer (NSCLC) and its clinical significance. METHODS: 101 patients were surgically…”
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Apoptosis, bcl-2 Expression, and Proliferation in Benign and Malignant Endometrial Epithelium: An Approach Using Multiparameter Flow Cytometry by Morsi, Hassan M., Leers, Mathie P.G., Radespiel-Tröger, Martin, Björklund, Viveka, Kabarity, Hamdi El, Nap, Marius, Jäger, Wolfram

“…Objective. Disturbances in the regulation of cell proliferation and differentiation play an important role in the formation of neoplastic lesions…”
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The Patterns of Expression of an Apoptosis-Related CK18 Neoepitope, the bcl-2 Proto-Oncogene, and the Ki67 Proliferation Marker in Normal, Hyperplastic, and Malignant Endometrium by Morsi, Hassan M, Leers, Mathie P.G, Jäger, Wolfram, Björklund, Viveka, Radespiel-Tröger, Martin, Kabarity, Hamdy El, Nap, Marius, Lang, Norbert

“…Expression of a neoepitope on cytokeratin 18, recognized by the monoclonal antibody M30, is an early indicator of apoptosis in epithelial cells. The aim of…”
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A novel flow cytometric steroid hormone receptor assay for paraffin-embedded breast carcinomas : An objective quantification of the steroid hormone receptors and direct correlation to ploidy status and proliferative capacity in a single-tube assay by LEERS, M. P. G, SCHUTTE, B, THEUNISSEN, P. H. M. H, RAMAEKERS, F. C. S, NAP, M

“…Semiquantitative estimation of steroid hormone receptors by immunohistochemistry applied to paraffin sections is common practice in surgical pathology. Flow…”
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Evaluation of the membrane attack complex of complement for the detection of a recent myocardial infarction in man by Robert-Offerman, Saskia R., Leers, Mathie P. G., van Suylen, Robert J., Nap, Marius, Daemen, Mat J. A. P., Theunissen, Paul H. M. H.

“…The diagnosis of an acute myocardial infarction (MI) can be cumbersome for pathologists. Even with a positive nitroblue tetrazolium (NBT) reaction,…”
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Clonality assessment of lymphoproliferative disorders by multiparameter flow cytometry of paraffin-embedded tissue : An additional diagnostic tool in surgical pathology by LEERS, M. P. G, THEUNISSEN, P. H. M. H, RAMAEKERS, F. C. S, SCHUTTE, B, NAP, M

“…A major drawback of immunohistochemical detection of monoclonality in B-cell lymphoproliferative disorders is the lack of contrast between…”
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Proliferating cell nuclear antigen (PCNA) expression in formalin-fixed tissue of non-small cell lung carcinoma by Theunissen, P H, Leers, M P, Bollen, E C

“…An immunohistochemical study of non-small cell lung carcinoma using PC10, a monoclonal antibody against PCNA, was performed on tissues routinely processed with…”
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