Search Results - "Leeper, F."

Structure, mechanism and catalytic duality of thiamine-dependent enzymes by Frank, R. A. W, Leeper, F. J, Luisi, B. F

“…Thiamine is an essential cofactor that is required for processes of general metabolism amongst all organisms, and it is likely to have played a role in the…”
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Structure of the Fundamental Lipopeptide Surfactin at the Air/Water Interface Investigated by Sum Frequency Generation Spectroscopy by Goussous, S. A, Casford, M. T. L, Murphy, A. C, Salmond, G. P. C, Leeper, F. J, Davies, P. B

“…The lipopeptide surfactin produced by certain strains of Bacillus subtilis is a powerful biosurfactant possessing potentially useful antimicrobial properties…”
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Validation of a homology model of Mycobacterium tuberculosis DXS: rationalization of observed activities of thiamine derivatives as potent inhibitors of two orthologues of DXS by Masini, T, Lacy, B, Monjas, L, Hawksley, D, de Voogd, A R, Illarionov, B, Iqbal, A, Leeper, F J, Fischer, M, Kontoyianni, M, Hirsch, A K H

“…The enzyme DXS catalyzes the first, rate-limiting step of the 2-C-methyl-d-erythritol-4-phosphate (MEP, 1) pathway using thiamine diphosphate (ThDP) as…”
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Kinetics of the Thiazolium Ion-Catalyzed Benzoin Condensation by White, Marcus J, Leeper, Finian J

“…The formation of benzoin (Ph-CHOH-CO-Ph) from two molecules of benzaldehyde, catalyzed by 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide in methanol…”
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Assays for the Screening and Characterization of Tau Aggregation Inhibitors by Horsley, David, Rickard, Janet E, Vorley, Thomas, Leeper, Matilda F, Wischik, Claude M, Harrington, Charles R

“…Aggregation of tau protein is a pathological hallmark of Alzheimer's disease and other neurodegenerative tauopathies. Inhibition of tau aggregation may provide…”
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Disruption of the copper efflux pump (CopA) of Serratia marcescens ATCC 274 pleiotropically affects copper sensitivity and production of the tripyrrole secondary metabolite, prodigiosin by Williamson, N. R, Simonsen, H. T, Harris, A. K. P, Leeper, F. J, Salmond, George P. C

“…The prodigiosin biosynthetic gene cluster (pig cluster) of Serratia marcescens ATCC 274 (Sma 274) is flanked by cueR/copA homologues. Inactivation of the copA…”
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The Serratia gene cluster encoding biosynthesis of the red antibiotic, prodigiosin, shows species- and strain-dependent genome context variation by Harris, Abigail K. P, Williamson, Neil R, Slater, Holly, Cox, Anthony, Abbasi, Sophia, Foulds, Ian, Simonsen, Henrik T, Leeper, Finian J, Salmond, George P. C

“…1 Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK 2 Department of Chemistry, University of Cambridge, Lensfield…”
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Studies on thiamine diphosphate-dependent enzymes by Leeper, F J, Hawksley, D, Mann, S, Perez Melero, C, Wood, M D H

“…The 3-deaza analogue of TPP (thiamine diphosphate), a close mimic of the ylid intermediate, has been synthesized and is an extremely potent inhibitor of a…”
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The biosynthesis of porphyrins, chlorophylls, and vitamin B12 by Leeper, F J

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Biosynthesis of Vitamin B12: Structure of Precorrin-6x Octamethyl Ester by Thibaut, Denis, Blanche, Francis, Debussche, Laurent, Leeper, Finian J., Battersby, Alan R.

“…13C-labeled precorrin-6x is biosynthesized by cell-free protein preparations from Pseudomonas denitrificans in separate experiments using…”
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The biosynthesis of porphyrins, chlorophylls, and vitamin B12 by Leeper, F J

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The biosynthesis of porphyrins, chlorophylls, and vitamin B12 by Leeper, F J

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The biosynthesis of porphyrins, chlorophylls, and vitamin B12 by Leeper, F J

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Clinical and subclinical ophthalmic findings with retinol deficiency by Newman, N J, Capone, A, Leeper, H F, O'Day, D G, Mandell, B, Lambert, S R, Thoft, R A

“…Patients at risk for retinol deficiency in developed countries include those with hepatic dysfunction and malabsorption states. Symptoms of retinol deficiency…”
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Crystallographic Snapshots of Oxalyl-CoA Decarboxylase Give Insights into Catalysis by Nonoxidative ThDP-Dependent Decarboxylases by Berthold, Catrine L., Toyota, Cory G., Moussatche, Patricia, Wood, Martin D., Leeper, Finian, Richards, Nigel G.J., Lindqvist, Ylva

“…Despite more than five decades of extensive studies of thiamin diphosphate (ThDP) enzymes, there remain many uncertainties as to how these enzymes achieve…”
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Abstracts of the 26th international isotope society (UK group) symposium: Synthesis & applications of labelled compounds 2017 by Aboagye, E., Aigbirhio, F., Allott, L., Anderson, E.A., Artelsmair, M., Audisio, D., Audisio, J., Bragg, R., Brindle, K., Bulat, F., Bürli, R., Carroll, L., Chapdelaine, M., Collins, S., Cortezon‐Tamarit, F., Da Pieve, C., Davies, J.R., Decuypere, E., Defay, T., DeFrees, S., Dilworth, J., Duckett, S.B., Dugave, C., Elhabiri, M., Elmore, C.S., Fairlamb, I.J.S., Fenwick, A., Forsback, S., Ge, H., Geach, N., Gouverneur, V., Gregson, T., Gu, C., Ivanov, P., Kagoro, M.P., Kerr, W.J., Kidd, G.L., Knox, G., Kolodych, S., Koniev, O., Krzyczmonik, A., Lawrie, K.W.M., Leeper, F., Lewis, R., Little, G., Liu, H., Lockley, W.J.S., Mekareeya, A., Mirabello, V., Morrissey, C., Neves, A., Pascu, S.I., Paton, R.S., Plougastel, L., Poot, A.J., Puhalo, N., Read, D., Reid, M., Robinson, A., Sardana, M., Sarpaki, S., Schou, M., Simmonds, A., Smith, G., Solin, J.C,..O., Soloviev, D., Talbot, E.P., Taran, F., Turton, D.R., Tuttle, T., Venanzi, N.A.E., Vugts, D.J., Wagner, A., Wang, L., Webster, B., White, R., Willis, C.L., Windhorst, A.D., Winfield, C., Xie, B.

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Goldfish Retina: Functional Polarization of Cone Horizontal Cell Dendrites and Synapses by Stell, William K., Lightfoot, David O., Wheeler, Thomas G., Leeper, Harold F.

“…In serial electron micrographs we observed that dendrites of goldfish cone horizontal cells are either central or lateral in ribbon synaptic triads, depending…”
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Modification of hydroxymethylbilane synthase (porphobilinogen deaminase) by pyridoxal 5'-phosphate. Demonstration of an essential lysine residue by Hart, G J, Leeper, F J, Battersby, A R

“…When hydroxymethylbilane synthase (porphobilinogen deaminase) from Euglena gracilis is incubated with pyridoxal 5'-phosphate at pH 7.0 and 0 degree C, it…”
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The evidence for a spirocyclic intermediate in the formation of uroporphyrinogen III by cosynthase by Leeper, F J

“…In the course of the cyclization of the linear tetrapyrrole hydroxymethylbilane to uroporphyrinogen III, catalysed by uroporphyrinogen III synthase…”
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The Role of His113 and His114 in Pyruvate Decarboxylase from Zymomonas Mobilis by Schenk, Gerhard, Leeper, Finian J., England, Renee, Nixon, Peter F., Duggleby, Ronald G.

“…Pyruvate decarboxylase (PDC) is one of several enzymes that require thiamin diphosphate (ThDP) and a divalent cation as essential cofactors. Recently, the…”
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