Search Results - "Leenen, Frans"

Inhibition of inflammation by minocycline improves heart failure and depression-like behaviour in rats after myocardial infarction by Wang, Hong-Wei, Ahmad, Monir, Jadayel, Rami, Najjar, Fatimah, Lagace, Diane, Leenen, Frans H H

“…Patients with heart failure have an increased incidence of depression. Central and peripheral inflammation play a major role in the pathophysiology of both…”
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Mineralocorticoid and angiotensin II type 1 receptors in the subfornical organ mediate angiotensin II – Induced hypothalamic reactive oxygen species and hypertension by Wang, Hong-Wei, Huang, Bing S, White, Roselyn A, Chen, Aidong, Ahmad, Monir, Leenen, Frans H.H

“…Graphical abstract Schematic outline of the interactive role of central aldosterone-MR signaling and AT1 R-ROS signaling pathways for progressive hypertension…”
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Changes in the rates of awareness, treatment and control of hypertension in Canada over the past two decades by McAlister, Finlay A, Wilkins, Kathryn, Joffres, Michel, Leenen, Frans H H, Fodor, George, Gee, Marianne, Tremblay, Mark S, Walker, Robin, Johansen, Helen, Campbell, Norm

“…Analyses of medication databases indicate marked increases in prescribing of antihypertensive drugs in Canada over the past decade. This study was done to…”
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Central neuromodulatory pathways regulating sympathetic activity in hypertension by Gabor, Alexander, Leenen, Frans H H

“…The classical neurotransmitters, glutamate and GABA, mediate fast (milliseconds) synaptic transmission and modulate its effectiveness through slow (seconds to…”
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Sex differences in depression-like behavior and neuroinflammation in rats post-MI: role of estrogens by Najjar, Fatimah, Ahmad, Monir, Lagace, Diane, Leenen, Frans H H

“…Patients with heart failure (HF) have a high prevalence of depression associated with a worse prognosis, particularly in older women. The present study…”
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Central Mineralocorticoid Receptors and the Role of Angiotensin II and Glutamate in the Paraventricular Nucleus of Rats With Angiotensin II–Induced Hypertension by Gabor, Alexander, Leenen, Frans H.H

“…A chronic increase in circulating angiotensin II (Ang II) activates an aldosterone–mineralocorticoid receptor-ouabain neuromodulatory pathway in the brain that…”
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The central role of the brain aldosterone–“ouabain” pathway in salt-sensitive hypertension by Leenen, Frans H.H.

“…Na+-transport regulating mechanisms classically considered to reflect renal control of sodium homeostasis and BP, i.e. aldosterone–mineralocorticoid receptors…”
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Salt-Induced Hypertension in a Mouse Model of Liddle Syndrome Is Mediated by Epithelial Sodium Channels in the Brain by Van Huysse, James W, Amin, Md Shahrier, Yang, Baoli, Leenen, Frans H.H

“…Neural precursor cell expressed and developmentally downregulated 4-2 protein (Nedd4-2) facilitates the endocytosis of epithelial Na channels (ENaCs). Both…”
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How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension by Blaustein, Mordecai P, Leenen, Frans H H, Chen, Ling, Golovina, Vera A, Hamlyn, John M, Pallone, Thomas L, Van Huysse, James W, Zhang, Jin, Wier, W Gil

“…Excess dietary salt is a major cause of hypertension. Nevertheless, the specific mechanisms by which salt increases arterial constriction and peripheral…”
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Sodium pumps, ouabain and aldosterone in the brain: A neuromodulatory pathway underlying salt-sensitive hypertension and heart failure by Leenen, Frans H.H., Wang, Hong-Wei, Hamlyn, John M.

“…[Display omitted] •Excess salt and/or angiotensin II stimulate a neuroendocrine pathway in the brain and raise blood pressure.•The pathway involves three…”
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Cardiovascular effects of angiotensin II and glutamate in the PVN of Dahl salt-sensitive rats by Gabor, Alexander, Leenen, Frans H.H

“…Abstract Several models of chronic sympathetic hyperactivity are associated with an increase in excitatory angiotensinergic and glutamatergic activity, and a…”
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Pivotal role of α2 Na+ pumps and their high affinity ouabain binding site in cardiovascular health and disease by Blaustein, Mordecai P., Chen, Ling, Hamlyn, John M., Leenen, Frans H. H., Lingrel, Jerry B., Wier, W. Gil, Zhang, Jin

“…Reduced smooth muscle (SM)‐specific α2 Na+ pump expression elevates basal blood pressure (BP) and increases BP sensitivity to angiotensin II (Ang II) and…”
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Effects of exercise on BDNF-TrkB signaling in the paraventricular nucleus and rostral ventrolateral medulla in rats post myocardial infarction by Lee, Heow Won, Ahmad, Monir, Wang, Hong-Wei, Leenen, Frans H.H.

“…Brain-derived neurotrophic factor (BDNF)-tropomyosin-related kinase B (TrkB) signaling in the paraventricular nucleus (PVN) and rostral ventrolateral medulla…”
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Whither digitalis? What we can still learn from cardiotonic steroids about heart failure and hypertension by Blaustein, Mordecai P, Gottlieb, Stephen S, Hamlyn, John M, Leenen, Frans H H

“…Cloning of the "Na pump" (Na ,K -ATPase or NKA) and identification of a circulating ligand, endogenous ouabain (EO), a cardiotonic steroid (CTS), triggered…”
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Role of Myocardial Infarction-Induced Neuroinflammation for Depression-Like Behavior and Heart Failure in Ovariectomized Female Rats by Najjar, Fatimah, Ahmad, Monir, Lagace, Diane, Leenen, Frans H.H.

“…After myocardial infarction (MI), ovariectomized (OVX) female rats develop depression-like behaviors and an increase of pro-inflammatory cytokine (PIC) levels…”
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Results of the Ontario survey on the prevalence and control of hypertension by Leenen, Frans H H, Dumais, Jean, McInnis, Natalie H, Turton, Penelope, Stratychuk, Lori, Nemeth, Kathleen, Moy Lum-Kwong, Margaret, Fodor, George

“…Available information on the prevalence and management of hypertension in the Canadian population dates back to 1986-1992 and probably does not reflect the…”
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Neuroendocrine humoral and vascular components in the pressor pathway for brain angiotensin II: a new axis in long term blood pressure control by Hamlyn, John M, Linde, Cristina I, Gao, Junjie, Huang, Bing S, Golovina, Vera A, Blaustein, Mordecai P, Leenen, Frans H H

“…Central nervous system (CNS) administration of angiotensin II (Ang II) raises blood pressure (BP). The rise in BP reflects increased sympathetic outflow and a…”
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Brain Mechanisms Contributing to Sympathetic Hyperactivity and Heart Failure by Leenen, Frans H.H

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Actions of Circulating Angiotensin II and Aldosterone in the Brain Contributing to Hypertension by Leenen, Frans H. H.

“…In the past 1-2 decades, it has become apparent that the brain renin-angiotensin-aldosterone system (RAAS) plays a crucial role in the regulation of blood…”
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Effects of exercise training on brain‐derived neurotrophic factor in skeletal muscle and heart of rats post myocardial infarction by Lee, Heow Won, Ahmad, Monir, Wang, Hong‐Wei, Leenen, Frans H. H.

“…New Findings What is the central question of this study? Exercise training increases brain‐derived neurotrophic factor (BDNF) in the hippocampus, which depends…”
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