Tolterodine Tartrate Proniosomal Gel Transdermal Delivery for Overactive Bladder

Tolterodine Tartrate Proniosomal Gel Transdermal Delivery for Overactive Bladder

The goal of this study was to formulate and evaluate side effects of transdermal delivery of proniosomal gel compared to oral tolterodine tartrate (TT) for the treatment of overactive bladder (OAB). Proniosomal gels are surfactants, lipids and soy lecithin, prepared by coacervation phase separation....

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Bibliographic Details
Published in:Pharmaceutics Vol. 8; no. 3; p. 27
Main Authors: Rajabalaya, Rajan, Leen, Guok, Chellian, Jestin, Chakravarthi, Srikumar, David, Sheba R
Format: Journal Article
Language:English
Published: Switzerland MDPI 31-08-2016
MDPI AG
Subjects:
cholesterol
overactive bladder
permeation
Proniosome
salivary secretion
transdermal
Proniosome
cholesterol
salivary secretion
permeation
transdermal
overactive bladder
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Summary:The goal of this study was to formulate and evaluate side effects of transdermal delivery of proniosomal gel compared to oral tolterodine tartrate (TT) for the treatment of overactive bladder (OAB). Proniosomal gels are surfactants, lipids and soy lecithin, prepared by coacervation phase separation. Formulations were analyzed for drug entrapment efficiency (EE), vesicle size, surface morphology, attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy, in vitro skin permeation, and in vivo effects. The EE was 44.87%-91.68% and vesicle size was 253-845 nm for Span formulations and morphology showed a loose structure. The stability and skin irritancy test were also carried out for the optimized formulations. Span formulations with cholesterol-containing formulation S1 and glyceryl distearate as well as lecithin containing S3 formulation showed higher cumulative percent of permeation such as 42% and 35%, respectively. In the in vivo salivary secretion model, S1 proniosomal gel had faster recovery, less cholinergic side effect on the salivary gland compared with that of oral TT. Histologically, bladder of rats treated with the proniosomal gel formulation S1 showed morphological improvements greater than those treated with S3. This study demonstrates the potential of proniosomal vesicles for transdermal delivery of TT to treat OAB.
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ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics8030027