Search Results - "Leen, C"

The nanosilica hazard: another variable entity by Napierska, Dorota, Thomassen, Leen C J, Lison, Dominique, Martens, Johan A, Hoet, Peter H

“…Silica nanoparticles (SNPs) are produced on an industrial scale and are an addition to a growing number of commercial products. SNPs also have great potential…”
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Characterization of Milli- and Microflow Reactors: Mixing Efficiency and Residence Time Distribution by Gobert, Sven R. L, Kuhn, Simon, Braeken, Leen, Thomassen, Leen C. J

“…The increasing academic and industrial interest in flow chemistry resulted in the development of various micro- and milliflow reactors for a wide range of…”
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Size‐Dependent Cytotoxicity of Monodisperse Silica Nanoparticles in Human Endothelial Cells by Napierska, Dorota, Thomassen, Leen C. J., Rabolli, Virginie, Lison, Dominique, Gonzalez, Laetitia, Kirsch‐Volders, Micheline, Martens, Johan A., Hoet, Peter H.

“…The effect that monodisperse amorphous spherical silica particles of different sizes have on the viability of endothelial cells (EAHY926 cell line) is…”
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Synthesis and Characterization of Stable Monodisperse Silica Nanoparticle Sols for in Vitro Cytotoxicity Testing by Thomassen, Leen C. J, Aerts, Alexander, Rabolli, Virginie, Lison, Dominique, Gonzalez, Laetitia, Kirsch-Volders, Micheline, Napierska, Dorota, Hoet, Peter H, Kirschhock, Christine E. A, Martens, Johan A

“…For the investigation of the interaction of nanoparticles with biomolecules, cells, organs, and animal models there is a need for well-characterized…”
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Carbon black and titanium dioxide nanoparticles elicit distinct apoptotic pathways in bronchial epithelial cells by Hussain, Salik, Thomassen, Leen C J, Ferecatu, Ioana, Borot, Marie-Caroline, Andreau, Karine, Martens, Johan A, Fleury, Jocelyne, Baeza-Squiban, Armelle, Marano, Francelyne, Boland, Sonja

“…Increasing environmental and occupational exposures to nanoparticles (NPs) warrant deeper insight into the toxicological mechanisms induced by these materials…”
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The cytotoxic activity of amorphous silica nanoparticles is mainly influenced by surface area and not by aggregation by Rabolli, Virginie, Thomassen, Leen C.J., Uwambayinema, Francine, Martens, Johan A., Lison, Dominique

“…► Influence of nanoparticle aggregation on toxicity was investigated with silica-based materials. ► No impact of aggregation on cytotoxicity was found in J774…”
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Nominal and Effective Dosimetry of Silica Nanoparticles in Cytotoxicity Assays by Lison, Dominique, Thomassen, Leen C. J., Rabolli, Virginie, Gonzalez, Laetitia, Napierska, Dorota, Seo, Jin Won, Kirsch-Volders, Micheline, Hoet, Peter, Kirschhock, Christine E. A., Martens, Johan A.

“…Because of their small size and large specific surface area (SA), insoluble nanoparticles are almost not affected by the gravitational force and are generally…”
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Oxidative Stress Induced by Pure and Iron-Doped Amorphous Silica Nanoparticles in Subtoxic Conditions by Napierska, Dorota, Rabolli, Virginie, Thomassen, Leen C. J, Dinsdale, David, Princen, Catherine, Gonzalez, Laetitia, Poels, Katrien L. C, Kirsch-Volders, Micheline, Lison, Dominique, Martens, Johan A, Hoet, Peter H

“…Amorphous silica nanoparticles (SiO2-NPs) have found broad applications in industry and are currently intensively studied for potential uses in medical and…”
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Editorial: direct‐acting anti‐virals – not the be‐all and end‐all in HIV/HCV co‐infection by Bulteel, N., Leen, C.

“…Linked ContentThis article is linked to Schwabl et al papers. To view these articles visit https://doi.org/10.1111/apt.13844 and…”
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Oxidative stress and proinflammatory effects of carbon black and titanium dioxide nanoparticles: Role of particle surface area and internalized amount by Hussain, Salik, Boland, Sonja, Baeza-Squiban, Armelle, Hamel, Rodolphe, Thomassen, Leen C.J, Martens, Johan A, Billon-Galland, Marie Annick, Fleury-Feith, Jocelyne, Moisan, Frédéric, Pairon, Jean-Claude, Marano, Francelyne

“…Abstract The ubiquitous presence of nanoparticles (NPs) together with increasing evidence linking them to negative health effects points towards the need to…”
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Procedural and clinical impact of intracoronary lithotripsy in heavily calcified aorto‐ostial coronary lesions by Oliveri, Federico, Meijer, Maura, Van Oort, Martijn J. H., Al Amri, Ibtihal, Bingen, Brian O., Claessen, Bimmer E., Dimitriu‐Leen, Aukelien C., Kefer, Joelle, Girgis, Hany, Vossenberg, Tessel, Van der Kley, Frank, Jukema, J. Wouter, Montero‐Cabezas, Jose M.

“…Background Percutaneous coronary intervention of calcified aorto‐ostial lesions (AOL) pose unique challenges due to anatomical propensity for recoil, leading…”
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Intravascular lithotripsy in heavily calcified chronic total occlusion: procedural and one‐year clinical outcomes by Oliveri, Federico, Oort, Martijn J. H., Al Amri, Ibtihal, Bingen, Brian O., Claessen, Bimmer E., Dimitriu‐Leen, Aukelien C., Kefer, Joelle, Girgis, Hany, Vossenberg, Tessel, van der, Frank, Jukema, J. Wouter, Montero‐Cabezas, Jose M.

“…Background Calcification within chronic total occlusions (CTO) is strongly associated with worse outcomes. Despite the excellent success and safety of…”
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Energy efficient crystallization of paracetamol using pulsed ultrasound by Gielen, Bjorn, Kusters, Piet, Jordens, Jeroen, Thomassen, Leen C.J., Van Gerven, Tom, Braeken, Leen

“…[Display omitted] •Sonication in pulsed mode yields same nucleation temperature as continuous mode.•Bubble dissolution calculations allow to determine minimal…”
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Agglomeration Control during Ultrasonic Crystallization of an Active Pharmaceutical Ingredient by Gielen, Bjorn, Jordens, Jeroen, Thomassen, Leen C J, Braeken, Leen, VanGerven, Tom

“…Application of ultrasound during crystallization can efficiently inhibit agglomeration. However, the mechanism is unclear and sonication is usually enabled…”
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Cytokine production by co-cultures exposed to monodisperse amorphous silica nanoparticles: The role of size and surface area by Napierska, Dorota, Thomassen, Leen C.J., Vanaudenaerde, Bart, Luyts, Katrien, Lison, Dominique, Martens, Johan A., Nemery, Benoit, Hoet, Peter H.M.

“…[Display omitted] ► Size and surface area of silica nanoparticles have influence on cytokine secretion. ► The smallest nanoparticles induce the most pronounced…”
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Amorphous Silica Nanoparticles Promote Monocyte Adhesion to Human Endothelial Cells: Size-Dependent Effect by Napierska, Dorota, Quarck, Rozenn, Thomassen, Leen C. J., Lison, Dominique, Martens, Johan A., Delcroix, Marion, Nemery, Benoit, Hoet, Peter H.

“…There is evidence that nanoparticles can induce endothelial dysfunction. Here, the effect of monodisperse amorphous silica nanoparticles (SiO2‐NPs) of…”
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UK consensus guidelines for the use of the protease inhibitors boceprevir and telaprevir in genotype 1 chronic hepatitis C infected patients by Ramachandran, P., Fraser, A., Agarwal, K., Austin, A., Brown, A., Foster, G. R., Fox, R., Hayes, P. C., Leen, C., Mills, P. R., Mutimer, D. J., Ryder, S. D., Dillon, J. F.

“…Summary Background The nonstructural 3 serine protease inhibitors (PIs), boceprevir and telaprevir, represent the first in a new generation of directly acting…”
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Editorial: NAFLD in HIV infection – call for action by Bulteel, N., Leen, C.

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Reducing the Induction Time Using Ultrasound and High-Shear Mixing in a Continuous Crystallization Process by Vancleef, Arne, Seurs, Stijn, Jordens, Jeroen, Van Gerven, Tom, Thomassen, Leen C. J., Braeken, Leen

“…Continuous crystallization in tubular crystallizers is of particular interest to the pharmaceutical industry to accurately control average particle size,…”
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Model System to Study the Influence of Aggregation on the Hemolytic Potential of Silica Nanoparticles by Thomassen, Leen C. J, Rabolli, Virginie, Masschaele, Kasper, Alberto, Gabriele, Tomatis, Maura, Ghiazza, Mara, Turci, Francesco, Breynaert, Eric, Martra, Gianmario, Kirschhock, Christine E. A, Martens, Johan A, Lison, Dominique, Fubini, Bice

“…A well-defined silica nanoparticle model system was developed to study the effect of the size and structure of aggregates on their membranolytic activity. The…”
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