Search Results - "Leeming, D. J."

Turnover of type I and III collagen predicts progression of idiopathic pulmonary fibrosis by Jessen, H, Hoyer, N, Prior, T S, Frederiksen, P, Karsdal, M A, Leeming, D J, Bendstrup, E, Sand, J M B, Shaker, S B

“…Idiopathic pulmonary fibrosis (IPF) is characterized by the accumulation of fibrillar collagens in the alveolar space resulting in reduced pulmonary function…”
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Excessive collagen turnover products are released during colorectal cancer progression and elevated in serum from metastatic colorectal cancer patients by Kehlet, S. N., Sanz-Pamplona, R., Brix, S., Leeming, D. J., Karsdal, M. A., Moreno, V.

“…During cancer progression, the homeostasis of the extracellular matrix becomes imbalanced with an excessive collagen remodeling by matrix metalloproteinases…”
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Can biomarkers of extracellular matrix remodelling and wound healing be used to identify high risk patients infected with SARS-CoV-2?: lessons learned from pulmonary fibrosis by Leeming, D J, Genovese, F, Sand, J M B, Rasmussen, D G K, Christiansen, C, Jenkins, G, Maher, T M, Vestbo, J, Karsdal, M A

“…Pulmonary fibrosis has been identified as a main factor leading to pulmonary dysfunction and poor quality of life in post-recovery Severe Acute Respiratory…”
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Novel serological neo‐epitope markers of extracellular matrix proteins for the detection of portal hypertension by Leeming, D. J., Karsdal, M. A., Byrjalsen, I., Bendtsen, F., Trebicka, J., Nielsen, M. J., Christiansen, C., Møller, S., Krag, A.

“…Summary Background The hepatic venous pressure gradient (HVPG) is an invasive, but important diagnostic and prognostic marker in cirrhosis with portal…”
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Review article: the efficacy of biomarkers in chronic fibroproliferative diseases – early diagnosis and prognosis, with liver fibrosis as an exemplar by Karsdal, M. A., Krarup, H., Sand, J. M. B., Christensen, P. B., Gerstoft, J., Leeming, D. J., Weis, N., Schaffalitzky de Muckadell, O. B., Krag, A.

“…Summary Background Nearly 45% of all deaths are associated with chronic fibroproliferative diseases, of which the primary characteristic is altered remodelling…”
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Bisphosphonates alter trabecular bone collagen cross-linking and isomerization in beagle dog vertebra by Allen, M. R., Gineyts, E., Leeming, D. J., Burr, D. B., Delmas, P. D.

“…Summary Changes in organic matrix may contribute to the anti-fracture efficacy of anti-remodeling agents. Following one year of treatment in beagle dogs,…”
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Contribution of the advanced glycation end product pentosidine and of maturation of type I collagen to compressive biomechanical properties of human lumbar vertebrae by Viguet-Carrin, S., Roux, J.P., Arlot, M.E., Merabet, Z., Leeming, D.J, Byrjalsen, I., Delmas, P.D., Bouxsein, M.L.

“…Collagen characteristics contribute to bone biomechanical properties. Yet, few studies have analyzed the independent contributions of bone mineral density…”
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Post-translational modifications of the extracellular matrix are key events in cancer progression: Opportunities for biochemical marker development by Leeming, D. J., Bay-Jensen, A. C., Vassiliadis, E., Larsen, M. R., Henriksen, K., Karsdal, M. A.

“…The aim of this review is to discuss the potential usefulness of a novel class of biochemical markers, designated neoepitopes. Neoepitopes are…”
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Should subchondral bone turnover be targeted when treating osteoarthritis? by Karsdal, M.A., M.Sc., Ph.D, Leeming, D.J., M.Sc, Dam, E.B., M.Sc., Ph.D, Henriksen, K., M.Sc., Ph.D, Alexandersen, P., M.Sc., Ph.D, Pastoureau, P., Ph.D, Altman, R.D., M.D, Christiansen, C., M.D

“…Summary Objective Osteoarthritis (OA) is the most common form of arthritic disease, and it is a major cause of disability and impaired quality of life in the…”
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An update on biomarkers of bone turnover and their utility in biomedical research and clinical practice by LEEMING, D. J, ALEXANDERSEN, P, KARSDAL, M. A, QVIST, P, SCHALLER, S, TANKO, L. B

“…Maintenance of the structural and functional integrity of the skeleton is a critical function of a continuous remodeling driven by highly associated processes…”
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Aggrecanase degradation of type III collagen is associated with clinical knee pain by Bay-Jensen, A.C., Kjelgaard-Petersen, C.F., Petersen, K.K., Arendt-Nielsen, L., Quasnichka, H.L., Mobasheri, A., Karsdal, M.A., Leeming, D.J.

“…There is a lack of biochemical markers for non-invasive and objective assessment of symptomatic osteoarthritis (OA). Aggrecanase activity has been shown to be…”
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Bone turnover and bone collagen maturation in osteoporosis: effects of antiresorptive therapies by Byrjalsen, I., Leeming, D. J., Qvist, P., Christiansen, C., Karsdal, M. A.

“…Summary Bone collagen maturation may be important for anti-fracture efficacy as the reduction in risk is only partly explained by a concomitant increase in BMD…”
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Circulating Elastin Fragments Are Not Affected by Hepatic, Renal and Hemodynamic Changes, But Reflect Survival in Cirrhosis with TIPS by Nielsen, M. J., Lehmann, J., Leeming, D. J., Schierwagen, R., Klein, S., Jansen, C., Strassburg, C. P., Bendtsen, F., Møller, S., Sauerbruch, T., Karsdal, M. A., Krag, A., Trebicka, J.

“…Background and Aims Progressive fibrosis increases hepatic resistance and causes portal hypertension with complications. During progressive fibrosis remodeling…”
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Is bone quality associated with collagen age by Leeming, D. J, Henriksen, K, Byrjalsen, I, Qvist, P, Madsen, S. H, Garnero, P, Karsdal, M. A

“…The World Health Organization defines osteoporosis as a systemic disease characterized by decreased bone tissue mass and microarchitectural deterioration,…”
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Biochemical markers and the FDA Critical Path: How biomarkers may contribute to the understanding of pathophysiology and provide unique and necessary tools for drug development by Karsdal, M.A., Henriksen, K., Leeming, D.J., Mitchell, P., Duffin, K., Barascuk, N., Klickstein, L., Aggarwal, P., Nemirovskiy, O., Byrjalsen, I., Qvist, P., Bay-Jensen, A.C., Dam, E.B., Madsen, S.H., Christiansen, C.

“…The aim of this review is to discuss the potential usefulness of a novel class of biochemical markers, neoepitopes, in the context of the US Food and Drug…”
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Investigation of two novel biochemical markers of inflammation, matrix metalloproteinase and cathepsin generated fragments of C-reactive protein, in patients with ankylosing spondylitis by SKJØT-ARKIL, H, SCHETT, G, CHRISTIANSEN, C, ALEXANDERSEN, P, LEEMING, D. J, KARSDAL, M. A, ZHANG, C, LARSEN, D. V, WANG, Y, ZHENG, Q, LARSEN, M. R, NAWROCKI, A, BAY-JENSEN, A.-C, HENRIKSEN, K

“…Ankylosing spondylitis (AS) is a chronic inflammation of the spine and the sacroiliac joints. Current markers of inflammation, such as C-reactive protein…”
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Enzyme-linked immunosorbent serum assays (ELISAs) for rat and human N-terminal pro-peptide of collagen type I (PINP) — Assessment of corresponding epitopes by Leeming, D.J., Larsen, D.V., Zhang, C., Hi, Y., Veidal, S.S., Nielsen, R.H., Henriksen, K., Zheng, Q., Barkholt, V., Riis, B.J., Byrjalsen, I., Qvist, P., Karsdal, M.A.

“…The present study describes two newly developed N-terminal pro-peptides of collagen type I (PINP) competitive enzyme-linked immunosorbent assays (ELISAs) for…”
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The good and the bad collagens of fibrosis – Their role in signaling and organ function by Karsdal, M.A., Nielsen, S.H., Leeming, D.J., Langholm, L.L., Nielsen, M.J., Manon-Jensen, T., Siebuhr, A., Gudmann, N.S., Rønnow, S., Sand, J.M., Daniels, S.J., Mortensen, J.H., Schuppan, D.

“…Usually the dense extracellular structure in fibrotic tissues is described as extracellular matrix (ECM) or simply as collagen. However, fibrosis is not just…”
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Osteoclasts prefer aged bone by HENRIKSEN, K, LEEMING, D. J, BYRJALSEN, I, NIELSEN, R. H, SORENSEN, M. G, DZIEGIEL, M. H, MARTIN, T. John, CHRISTIANSEN, C, QVIST, P, KARSDAL, M. A

“…We investigated whether the age of the bones endogenously exerts control over the bone resorption ability of the osteoclasts, and found that osteoclasts…”
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The effects of oral calcitonin on bone collagen maturation: implications for bone turnover and quality by Karsdal, M. A., Byrjalsen, I., Leeming, D. J., Delmas, P. D., Christiansen, C.

“…Summary Anti-resorptive strategies may affect bone collagen maturation differently depending on the mode of action. Orally administrated calcitonin resulted in…”
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