Search Results - "Leelakumari, Sreeja"

Homologous Recombination Deficiency and Platinum-Based Therapy Outcomes in Advanced Breast Cancer by Zhao, Eric Y, Shen, Yaoqing, Pleasance, Erin, Kasaian, Katayoon, Leelakumari, Sreeja, Jones, Martin, Bose, Pinaki, Ch'ng, Carolyn, Reisle, Caralyn, Eirew, Peter, Corbett, Richard, Mungall, Karen L, Thiessen, Nina, Ma, Yussanne, Schein, Jacqueline E, Mungall, Andrew J, Zhao, Yongjun, Moore, Richard A, Den Brok, Wendie, Wilson, Sheridan, Villa, Diego, Shenkier, Tamara, Lohrisch, Caroline, Chia, Stephen, Yip, Stephen, Gelmon, Karen, Lim, Howard, Renouf, Daniel, Sun, Sophie, Schrader, Kasmintan A, Young, Sean, Bosdet, Ian, Karsan, Aly, Laskin, Janessa, Marra, Marco A, Jones, Steven J M

“…Recent studies have identified mutation signatures of homologous recombination deficiency (HRD) in over 20% of breast cancers, as well as pancreatic, ovarian,…”
Get full text

The pink salmon genome: Uncovering the genomic consequences of a two-year life cycle by Christensen, Kris A, Rondeau, Eric B, Sakhrani, Dionne, Biagi, Carlo A, Johnson, Hollie, Joshi, Jay, Flores, Anne-Marie, Leelakumari, Sreeja, Moore, Richard, Pandoh, Pawan K, Withler, Ruth E, Beacham, Terry D, Leggatt, Rosalind A, Tarpey, Carolyn M, Seeb, Lisa W, Seeb, James E, Jones, Steven J M, Devlin, Robert H, Koop, Ben F

“…Pink salmon (Oncorhynchus gorbuscha) adults are the smallest of the five Pacific salmon native to the western Pacific Ocean. Pink salmon are also the most…”
Get full text

The genome sequence of the Loggerhead sea turtle, Caretta caretta Linnaeus 1758 [version 2; peer review: 2 approved] by Chang, Glenn, Jones, Samantha, Leelakumari, Sreeja, Ashkani, Jahanshah, Culibrk, Luka, O'Neill, Kieran, Tse, Kane, Cheng, Dean, Chuah, Eric, McDonald, Helen, Kirk, Heather, Pandoh, Pawan, Pari, Sauro, Angelini, Valeria, Kyle, Christopher, Bertorelle, Giorgio, Zhao, Yongjun, Mungall, Andrew, Moore, Richard, Vilaça, Sibelle, Jones, Steven

“…We present a genome assembly of Caretta caretta (the Loggerhead sea turtle; Chordata, Testudines, Cheloniidae), generated from genomic data from two unrelated…”
Get full text

The genome sequence of the Loggerhead sea turtle, Caretta caretta Linnaeus 1758 [version 1; peer review: 1 approved, 1 approved with reservations] by Chang, Glenn, Jones, Samantha, Leelakumari, Sreeja, Ashkani, Jahanshah, Culibrk, Luka, O'Neill, Kieran, Tse, Kane, Cheng, Dean, Chuah, Eric, McDonald, Helen, Kirk, Heather, Pandoh, Pawan, Pari, Sauro, Angelini, Valeria, Kyle, Christopher, Bertorelle, Giorgio, Zhao, Yongjun, Mungall, Andrew, Moore, Richard, Vilaça, Sibelle, Jones, Steven

“…We present a genome assembly of Caretta caretta (the Loggerhead sea turtle; Chordata, Testudines, Cheloniidae), generated from genomic data from two unrelated…”
Get full text

Possible risk modification by CYP1A1, GSTM1 and GSTT1 gene polymorphisms in lung cancer susceptibility in a South Indian population by Sreeja, Leelakumari, Syamala, Vani, Hariharan, Sreedharan, Madhavan, Jayaprakash, Devan, Sivanandan Choondal, Ankathil, Ravindran

“…Susceptibility to lung cancer has been shown to be modulated by inheritance of polymorphic genes encoding cytochrome P450 1A1 (CYP1A1) and glutathione S…”
Get full text

Prognostic importance of DNA repair gene polymorphisms of XRCC1 Arg399Gln and XPD Lys751Gln in lung cancer patients from India by Sreeja, Leelakumari, Syamala, Volga S., Syamala, Vani, Hariharan, Sreedharan, Raveendran, Praveenkumar B., Vijayalekshmi, R. V., Madhavan, Jayaprakash, Ankathil, Ravindran

“…Purpose Inter individual variation in lung cancer susceptibility may be modulated in part through genetic polymorphisms in the DNA repair genes, especially the…”
Get full text

The Genome of the Steller Sea Lion ( Eumetopias jubatus ) by Kwan, Harwood H, Culibrk, Luka, Taylor, Gregory A, Leelakumari, Sreeja, Tan, Ryan, Jackman, Shaun D, Tse, Kane, MacLeod, Tina, Cheng, Dean, Chuah, Eric, Kirk, Heather, Pandoh, Pawan, Carlsen, Rebecca, Zhao, Yongjun, Mungall, Andrew J, Moore, Richard, Birol, Inanc, Marra, Marco A, Rosen, David A S, Haulena, Martin, Jones, Steven J M

“…The Steller sea lion is the largest member of the Otariidae family and is found in the coastal waters of the northern Pacific Rim. Here, we present the Steller…”
Get full text

p53 Arg72Pro Polymorphism Predicts Survival Outcome in Lung Cancer Patients in Indian Population by Sreeja, Leelakumari, Syamala, Vani, Raveendran, Praveenkumar B., Santhi, Sarojam, Madhavan, Jayaprakash, Ankathil, Ravindran

“…In response to many forms of cellular stress, including DNA damage, the p53 protein functions to induce growth arrest, DNA repair, or apoptosis. Common allele…”
Get full text

Novel germline mutations in BRCA2 gene among 96 hereditary breast and breast-ovarian cancer families from Kerala, South India by SYAMALA, Vani, SREEJA, Leelakumari, SYAMALA, Volga S, VINODKUMAR, B, RAVEENDRAN, Praveenkumar B, SREEDHARAN, Hariharan, KUTTAPPAN, Ratheesan, BALAKRISHNAN, Lekshmi, ANKATHIL, Ravindran

“…Aim of the present study was to identify the genetic heterogeneity, prevalence and frequency of germline mutations of BRCA2 gene in Hereditary Breast/Ovarian…”
Get full text

Recurrent isochromosome 21 and multiple abnormalities in a patient suspected of having acute myeloid leukemia with eosinophilic differentiation -- a rare case from South India by Vijay, Sangeetha, Sarojam, Santhi, Raveendran, Sureshkumar, Syamala, Vani, Leelakumari, Sreeja, Narayanan, Geetha, Hariharan, Sreedharan

“…Acute myeloid leukemia (AML) is a phenotypically heterogeneous disorder. The M4 subtype of AML is frequently associated with the cytogenetic marker inversion…”
Get full text

Lessons learned from the application of whole-genome analysis to the treatment of patients with advanced cancers by Laskin, Janessa, Jones, Steven, Aparicio, Samuel, Chia, Stephen, Ch'ng, Carolyn, Deyell, Rebecca, Eirew, Peter, Fok, Alexandra, Gelmon, Karen, Ho, Cheryl, Huntsman, David, Jones, Martin, Kasaian, Katayoon, Karsan, Aly, Leelakumari, Sreeja, Li, Yvonne, Lim, Howard, Ma, Yussanne, Mar, Colin, Martin, Monty, Moore, Richard, Mungall, Andrew, Mungall, Karen, Pleasance, Erin, Rassekh, S Rod, Renouf, Daniel, Shen, Yaoqing, Schein, Jacqueline, Schrader, Kasmintan, Sun, Sophie, Tinker, Anna, Zhao, Eric, Yip, Stephen, Marra, Marco A

“…Given the success of targeted agents in specific populations it is expected that some degree of molecular biomarker testing will become standard of care for…”
Get full text

Abstract 4283: Whole genome sequencing is superior to cancer panels to aid in decision-making in patients with advanced malignancies by Laskin, Janessa J., Shen, Yaoqing, Lim, Howard, Gelmon, Karen A., Renouf, Daniel, Yip, Stephen, Huntsman, David, Tinker, Anna, Ho, Cheryl, Chia, Stephen, Li, Yvonne, Kasaian, Katayoon, Eirew, Peter, Leelakumari, Sreeja, Moore, Richard, Aparicio, Samuel, Ma, Yusanne, Jones, Steven, Marra, Marco

“…Abstract Background: It is increasingly common to use targeted cancer panels to assess for informative or actionable targets to guide cancer treatment. We…”
Get full text

Abstract 1122: Personalized oncogenomics in advanced stage breast cancer by Sun, Sophie, Gelmon, Karen A., Chia, Stephen, Lohrisch, Caroline, Shenkier, Tamara, Villa, Diego, Shen, Yaoqing, Jones, Martin, Pleasance, Erin, Kasaian, Katayoon, Eirew, Peter, Leelakumari, Sreeja, Ma, Yusanne, Ng, Tony, Yip, Stephen, Jones, Steven JM, Marra, Marco A., Laskin, Janessa J.

“…Abstract Background Breast cancer is a complex disease with clinical, pathological, and molecular heterogeneity. Recent studies have identified several…”
Get full text

Whole-genome DNA and RNA sequencing in patients with metastatic colorectal cancer (mCRC) by Baxter, Simon Daniel, Lim, Howard John, Shen, Yaoqing, Laskin, Janessa J., Renouf, Daniel John, Yip, Stephen, Huntsman, David, Chia, Stephen K. L., Li, Yvonne, Kasaian, Katayoon, Eirew, Peter, Leelakumari, Sreeja, Ma, Yussanne, Aparicio, Samuel, Jones, Steven, Marra, Marco

“…Abstract only…”
Get full text

Abstract 5340: Bioinformatic analyses approaches for personalized oncogenomics by Kasaian, Katayoon, Shen, Yaoqing, Leelakumari, Sreeja, Eirew, Peter, Li, Yvonne Y., Pleasance, Erin, Corbett, Richard, Mungall, Karen L., Schein, Jacquie, Mungall, Andrew J., Zhao, Yongjun, Moore, Richard A., Yip, Stephen, Gelmon, Karen, Lim, Howard, Renouf, Daniel, Roscoe, Robyn, Ma, Yussanne, Marra, Marco A., Laskin, Janessa, Jones, Steven J.

“…Abstract The Personalized Oncogenomics initiative at the British Columbia Cancer Agency aims to identify tumor-specific therapeutic targets in cancer patients…”
Get full text

The use of whole-genome sequencing in therapeutic for decision making in patients with advanced malignancies by Lim, Howard John, Shen, Yaoqing, Laskin, Janessa J., Gelmon, Karen A., Renouf, Daniel John, Sun, Sophie, Yip, Stephen, Huntsman, David, Tinker, Anna, Ho, Cheryl, Chia, Stephen K. L., Li, Yvonne, Kasaian, Katayoon, Eirew, Peter, Leelakumari, Sreeja, Aparicio, Samuel, Ma, Yussanne, Jones, Steven, Marra, Marco

“…Abstract only…”
Get full text

Influence of germline polymorphisms of GSTT1, GSTM1, and GSTP1 in familial versus sporadic breast cancer susceptibility and survival by Syamala, Volga S., Sreeja, Leelakumari, Syamala, Vani, Raveendran, Praveenkumar B., Balakrishnan, Rajan, Kuttan, Ratheesan, Ankathil, Ravindran

“…Identifying genes associated with familial inheritance of breast cancer continues to be a major goal of current research as the known high penetrance genes…”
Get full text

Glutathione S-transferase M1, T1 and P1 polymorphisms: susceptibility and outcome in lung cancer patients by Sreeja, Leelakumari, Syamala, Vani, Hariharan, Sreedharan, Syamala, Volga S, Raveendran, Praveenkumar B, Sivanandan, C D, Madhavan, Jayaprakash, Ankathil, Ravindran

“…The glutathione S-transferases (GSTs) are a superfamily of genes whose products are phase II enzymes, catalyzing the conjugation of reactive intermediates to…”
Get more information

Prognostic importance of DNA repair gene polymorphisms of XRCCI Arg399Gln and XPD Lys751Gln in lung cancer patients from India by SREEJA, Leelakumari, SYAMALA, Volga S, SYAMALA, Vani, HARIHARAN, Sreedharan, RAVEENDRAN, Praveenkumar B, VIJAYALEKSHMI, R. V, MADHAVAN, Jayaprakash, ANKATHIL, Ravindran

Get full text

Hereditary breast/ovarian cancer: clinicopathological characteristics and survival of BRCA2 positive and negative cases by Syamala, Vani, Syamala, Volga S, Sreeja, Leelakumari, Raveendran, Praveenkumar B, Vijayalekshmi, R V, Sheeja, V R, Santhi, S, Kuttan, Ratheesan, Abraham, Elizabeth K, Ankathil, Ravindran

“…The clinical and pathological characteristics and prognostic outcome of patients with hereditary breast/ovarian cancer and BRCA2 mutations are poorly known…”
Get more information