Search Results - "Leech, S H"

Upregulation of BAK by butyrate in the colon is associated with increased Sp3 binding by CHIRAKKAL, H, LEECH, S. H, BROOKES, K. E, PRAIS, A. L, WABY, J. S, CORFE, B. M

“…Butyrate is a key bioactive product of dietary fibre fermentation thought to play a key role in cancer prevention. One contributory mechanism in this role is…”
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A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy by OLIE, R. A, SIMOES-WÜST, A. P, BAUMANN, B, LEECH, S. H, FABBRO, D, STAHEL, R. A, ZANGEMEISTER-WITTKE, U

“…Survivin, an inhibitor of apoptosis protein, deserves attention as a selective target for cancer therapy because it lacks expression in differentiated adult…”
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Activity of a Novel bcl-2/bcl-xL-Bispecific Antisense Oligonucleotide Against Tumors of Diverse Histologic Origins by Gautschi, Oliver, Tschopp, Stefan, Olie, Robert A., Leech, Siân H., Simões-Wüst, A. Paula, Ziegler, Annemarie, Baumann, Bettina, Odermatt, Bernhard, Hall, Jonathan, Stahel, Rolf A., Zangemeister-Wittke, Uwe

“…Background: Increased expression of the anti-apoptotic proteins Bcl-2 and Bcl-xL is involved in the development and progression of many tumors. We recently…”
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A Novel Bispecific Antisense Oligonucleotide Inhibiting Both bcl-2 and bcl-xL Expression Efficiently Induces Apoptosis in Tumor Cells by Uwe Zangemeister-Wittke, Siân H. Leech, Robert A. Olie, A. Paula Simões-Wüst, Oliver Gautschi, Gerd H. Luedke, François Natt, Robert Häner, Pierre Martin, Jonathan Hall, Carlo M. Nalin, Rolf A. Stahel

“…Bcl-2 and Bcl-xL are inhibitors of apoptosis frequently overexpressed in solid tumors. The bcl-2 and bcl-xL mRNAs share a region of homology comprising…”
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Management of the sensitized cardiac recipient: the use of plasmapheresis and intravenous immunoglobulin by Leech, S.H., Lopez-Cepero, M., LeFor, W.M., DiChiara, L., Weston, M., Furukawa, S., Macha, M., Singhal, A., Wald, J.W., Nikolaidis, L.A., McClurken, J.B., Bove, A.A.

“…:  Previously, we reported that the combination of plasmapheresis (PP) and intravenous immunoglobulin (IVIg) allow sensitized patients to undergo orthotopic…”
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bcl‐xl antisense treatment induces apoptosis in breast carcinoma cells by Simões‐Wüst, A. Paula, Olie, Robert A., Gautschi, Oliver, Leech, Siân H., Häner, Robert, Hall, Jonathan, Fabbro, Doriano, Stahel, Rolf A., Zangemeister‐Wittke, Uwe

“…Upregulated expression of bcl‐xL is involved in the initiation and progression of breast cancer by inhibiting tumor cell apoptosis. Here we describe the use of…”
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Absolute Lymphocyte Count as a Predictor of CD4 Count by Shapiro, Nathan I, Karras, David J, Leech, Stephen H, Heilpern, Katherine L

“…Study objective: To determine whether the absolute lymphocyte count (ALC) (white blood count×lymphocyte percentage) can be used to predict a low CD4 count…”
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Transmission of human immunodeficiency virus by transplantation of a renal allograft, with development of the acquired immunodeficiency syndrome by Kumar, P, Pearson, J E, Martin, D H, Leech, S H, Buisseret, P D, Bezbak, H C, Gonzalez, F M, Royer, J R, Streicher, H Z, Saxinger, W C

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The immune system in hereditary hemochromatosis: a quantitative and functional assessment of the cellular arm by Bryan, C F, Leech, S H, Kumar, P, Gaumer, R, Bozelka, B, Morgan, J

“…The objective of this investigation was to evaluate certain quantitative and functional characteristics of the effector cells of the cellular arm of the immune…”
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The immunoregulatory nature of iron. II. Lymphocyte surface marker expression by Bryan, C F, Leech, S H, Bozelka, B

“…Previously, we presented preliminary evidence that supported our hypothesis for the immunoregulatory nature of iron [7]. The objective of the present work was…”
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Preparation for hapten help by glucan, muramyl dipeptide, and its L-ala-Glycerol-mycolate derivative by Leech, S H, Di Luzio, N R, Leclerc, C

“…Previously, we reported that one of the factors that determines whether or not an animal will be prepared for hapten help after priming is the type of adjuvant…”
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Congenital 21-hydroxylase deficiency as a new deletion mutation. Detection in a proband during subsequent prenatal diagnosis by HLA typing and DNA analysis by Hejtmancik, J F, Black, S, Harris, S, Ward, P A, Callaway, C, Ledbetter, D, Morris, J, Leech, S H, Pollack, M S

“…A child with 21-OH-def whose 9 weeks' pregnant mother was referred for prenatal diagnosis was found upon very careful histocompatibility testing to lack…”
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ANTIBODY-MEDIATED REJECTION OCCURRING VERY LATE AFTER ORTHOTOPIC HEART TRANSPLANTATION: 277 by Ren, S., Leech, S. H.

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Respiratory allergies related to automobile air conditioners by Kumar, P, Marier, R, Leech, S H

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Cellular immunosenescence by Leech, S H

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ANTI HLA ANTIBODIES IN PATIENTS ON INFUSION THERAPY WITH ALPHA-1 ANTITRYPSIN PREPARATIONS: 1204 by Li, L. P., Kueppers, F., Patel, N., Leech, S. H.

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Induction of apoptosis in lung-cancer cells following bcl-xL anti-sense treatment by Leech, S H, Olie, R A, Gautschi, O, Simões-Wüst, A P, Tschopp, S, Häner, R, Hall, J, Stahel, R A, Zangemeister-Wittke, U

“…Over-expression of the anti-apoptotic protein bcl-xL is frequently found in lung cancer where it potentially contributes to tumor development, progression and…”
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Instability of immunoglobulins and complement (C3) as predictor of renal allograft rejection by Kumar, P, Kodlin, D, Lamarche, M B, Leech, S H

“…Ten renal allograft recipients were studied for a period of three months with weekly measurements of serum complement C3 including a baseline value before…”
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Thermostable erythrocyte rosette-forming lymphocytes in hereditary hemochromatosis. I: Identification in peripheral blood by BRYAN, C. F, LEECH, S. H, DUCOS, R, EDWARDS, C. Q, KUSHNER, J. P, SKOLNICK, M. H, BOZELKA, B, LINN, J. C, GAUMER, R

“…Although the immunoregulatory role of iron has been demonstrated in vitro, evidence for a similar role in vivo is controversial. We have, therefore, studied…”
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Thermostable erythrocyte rosettes in chronic renal failure and allograft rejection by Kumar, P, Leech, S H, Bryan, C F, Ducos, R S, Marks, C

“…Rejection of an allograft usually is preceded by activation of T lymphocytes, in which state such cells may be identified by their ability to form thermostable…”
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