Search Results - "Leebeek, F. W. G"

Compaction of fibrin clots reveals the antifibrinolytic effect of factor XIII by Rijken, D. C., Abdul, S., Malfliet, J. J. M. C., Leebeek, F. W. G., Uitte de Willige, S.

“…Essentials Factor XIIIa inhibits fibrinolysis by forming fibrin‐fibrin and fibrin‐inhibitor cross‐links. Conflicting studies about magnitude and mechanisms of…”
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Coagulation disorders after traumatic brain injury by Harhangi, B. S., Kompanje, E. J. O., Leebeek, F. W. G., Maas, A. I. R.

“…Summary Background. Over the past decade new insights in our understanding of coagulation have identified the prominent role of tissue factor. The brain is…”
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Anticoagulant therapy in patients with non‐cirrhotic portal vein thrombosis: effect on new thrombotic events and gastrointestinal bleeding by Spaander, M. C. W., Hoekstra, J., Hansen, B. E., Buuren, H. R., Leebeek, F. W. G., Janssen, H. L. A.

“…Summary Background and aims It remains unclear when anticoagulant therapy should be given in patients with non‐cirrhotic portal vein thrombosis (PVT). The aim…”
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The Hypercoagulable State in Cushing's Disease Is Associated with Increased Levels of Procoagulant Factors and Impaired Fibrinolysis, But Is Not Reversible after Short-Term Biochemical Remission Induced by Medical Therapy by van der Pas, R, de Bruin, C, Leebeek, F. W. G, de Maat, M. P. M, Rijken, D. C, Pereira, A. M, Romijn, J. A, Netea-Maier, R. T, Hermus, A. R, Zelissen, P. M. J, de Jong, F. H, van der Lely, A. J, de Herder, W. W, Lamberts, S. W. J, Hofland, L. J, Feelders, R. A

“…Context: Cushing's disease (CD) is accompanied by an increased risk of venous thromboembolism. Surgery is the primary treatment of CD. Objective: The aim of…”
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Perioperative treatment of hemophilia A patients: blood group O patients are at risk of bleeding complications by Hazendonk, H. C. A. M., Lock, J., Mathôt, R. A. A., Meijer, K., Peters, M., Laros‐van Gorkom, B. A. P., Meer, F. J. M., Driessens, M. H. E., Leebeek, F. W. G., Fijnvandraat, K., Cnossen, M. H.

“…Essentials Targeting of factor VIII values is a challenge during perioperative replacement therapy in hemophilia. This study aims to identify the extent and…”
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Lower levels of ADAMTS13 are associated with cardiovascular disease in young patients by Bongers, T.N, de Bruijne, E.L.E, Dippel, D.W.J, de Jong, A.J, Deckers, J.W, Poldermans, D, de Maat, M.P.M, Leebeek, F.W.G

“…Abstract ADAMTS13 may play a role in arterial thrombosis by cleaving the highly active and thrombogenic ultralarge Von Willebrand Factor (VWF) multimers into…”
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Health‐related quality of life among adult patients with moderate and severe von Willebrand disease by DE WEE, E. M., MAUSER‐BUNSCHOTEN, E. P., VAN DER BOM, J. G., DEGENAAR‐DUJARDIN, M. E. L., EIKENBOOM, H. C. J., FIJNVANDRAAT, K., DE GOEDE‐BOLDER, A., LAROS‐VAN GORKOM, B. A. P., MEIJER, K., RAAT, H., LEEBEEK, F. W. G

“…Background: von Willebrand Disease (VWD) is the most frequent inherited bleeding disorder. It is unknown how this disorder affects quality of life. Objectives:…”
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Hemophilic arthropathy in patients with von Willebrand disease by van Galen, K.P.M, Mauser-Bunschoten, E.P, Leebeek, F.W.G

“…Abstract von Willebrand disease (VWD) affects approximately 1% of the population. Joint bleeds are not a predominant symptom of VWD, however they do occur…”
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Prothrombotic disorders in abdominal vein thrombosis by LEEBEEK, F. W. G, SMALBERG, J. H, JANSSEN, H. L. A

“…Abdominal vein thrombosis is a rare, but potentially life-threatening form of venous thrombosis. It mainly involves the hepatic veins (Budd Chiari syndrome,…”
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High D‐dimer level is associated with increased 15‐d and 3 months mortality through a more central localization of pulmonary emboli and serious comorbidity by Klok, F. A., Djurabi, R. Karami, Nijkeuter, M., Eikenboom, H. C. J., Leebeek, F. W. G., Kramer, M. H. H., Kaasjager, K., Kamphuisen, P. W., Büller, H. R., Huisman, M. V.

“…Summary High D‐dimer levels are predictors of death in patients with pulmonary embolism (PE), as are more proximally located, larger emboli. The direct link…”
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Joint surgery in von Willebrand disease: a multicentre cross-sectional study by van Galen, K. P. M., Meijer, K., Vogely, H. C., Eikenboom, J., Schutgens, R. E. G., Cnossen, M. H., Fijnvandraat, K., van der Bom, J. G., Laros-van Gorkom, B. A. P., Leebeek, F. W. G., Mauser-Bunschoten, E. P.

“…Background Joint bleeds are reported by 23% of von Willebrand disease (VWD) patients and associated with orthopaedic surgery. Limited data are available on…”
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Acquired coagulopathy in patients with left ventricular assist devices by Muslem, R., Caliskan, K., Leebeek, F.W.G.

“…Summary Chronic heart failure (HF) is a major emerging healthcare problem, associated with a high morbidity and mortality. Left ventricular assist devices…”
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Oxidized high‐density lipoprotein reduces blood clot firmness by Talens, S., Malfliet, J. J. M. C., Leebeek, F. W. G., Rijken, D. C.

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Bleeding in critical care associated with left ventricular assist devices: pathophysiology, symptoms, and management by Leebeek, F W G, Muslem, R

“…Chronic heart failure (HF) is a growing health problem, and it is associated with high morbidity and mortality. Left ventricular assist devices (LVADs) are…”
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High D‐dimer levels increase the likelihood of pulmonary embolism by Tick, L. W., Nijkeuter, M., Kramer, M. H. H., Hovens, M. M. C., Büller, H. R., Leebeek, F. W. G., Huisman, M. V.

“… Objective.  To determine the utility of high quantitative D‐dimer levels in the diagnosis of pulmonary embolism. Methods.  D‐dimer testing was performed in…”
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The effect of genetic variants in the thrombin activatable fibrinolysis inhibitor (TAFI) gene on TAFI‐antigen levels, clot lysis time and the risk of venous thrombosis by Martini, C.H., Brandts, A., De Bruijne, E.L.E., Van Hylckama Vlieg, A., Leebeek, F.W.G., Lisman, T., Rosendaal, F.R.

“…Summary Thrombin activatable fibrinolysis inhibitor (TAFI) is an important inhibitor of fibrinolysis. High TAFI antigen levels are associated with an increased…”
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Treatment of hereditary angioedema with nanofiltered C1-esterase inhibitor concentrate (Cetor®): Multi-center phase II and III studies to assess pharmacokinetics, clinical efficacy and safety by Hofstra, J.J, Budde, I. Kleine, van Twuyver, E, Choi, G, Levi, M, Leebeek, F.W.G, de Monchy, J.G.R, Ypma, P.F, Keizer, R.J, Huitema, A.D.R, Strengers, P.F.W

“…Abstract From 1997, plasma-derived C1-inhibitor concentrate (Cetor®) has been available to HAE and AAE patients. Recently, a virus reducing 15 nm…”
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A diagnostic approach to mild bleeding disorders by Boender, J., Kruip, M. J. H. A., Leebeek, F. W. G.

“…Summary Mild inherited bleeding disorders are relatively common in the general population. Despite recent advances in diagnostic approaches, mild inherited…”
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Thrombotic complications without evidence of hemolysis in paroxysmal nocturnal hemoglobinuria: is eculizumab indicated? by Bellido, M., van der Velden, V. H. J., Leebeek, F. W. G., te Boekhorst, P. A. W.

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Fibrinogen γ’ levels in patients with intracerebral hemorrhage by van den Herik, E.G, Cheung, E.Y.L, de Lau, L.M.L, den Hertog, H.M, Leebeek, F.W.G, Dippel, D.W.J, Koudstaal, P.J, de Maat, M.P.M

“…Abstract Background The fibrinogen γ’ variant (γ’) has both antithrombotic and prothrombotic properties when compared to normal fibrinogen. It may therefore be…”
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