Search Results - "Lee-Wen Chen"
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The varicella-zoster virus ORF16 protein promotes both the nuclear transport and the protein abundance of the viral DNA polymerase subunit ORF28
Published in Virus research (01-07-2024)“…•Several VZV-encoded replication enzymes per se are localized in the cytoplasm.•The nuclear import of VZV ORF28 can be mediated by ORF16.•ORF16 can enhance the…”
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Kaposi's Sarcoma-Associated Herpesvirus ORF50 Protein Represses Cellular MDM2 Expression via Suppressing the Sp1- and p53-Mediated Transactivation
Published in International journal of molecular sciences (04-08-2022)“…The Kaposi's sarcoma-associated herpesvirus (KSHV)-encoded ORF50 protein is a potent transcriptional activator essential for triggering KSHV lytic…”
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3
The Epstein-Barr Virus Lytic Protein BMLF1 Induces Upregulation of GRP78 Expression through ATF6 Activation
Published in International journal of molecular sciences (14-04-2021)“…The unfolded protein response (UPR) is an intracellular signaling pathway essential for alleviating the endoplasmic reticulum (ER) stress. To support the…”
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Comparing Artificial Intelligence-Enabled Electrocardiogram Models in Identifying Left Atrium Enlargement and Long-term Cardiovascular Risk
Published in Canadian journal of cardiology (01-04-2024)“…The role of P-wave in identifying left atrial enlargement (LAE) with the use of artificial intelligence (AI)–enabled electrocardiography (ECG) models is…”
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Characterization of Human Norovirus Nonstructural Protein NS1.2 Involved in the Induction of the Filamentous Endoplasmic Reticulum, Enlarged Lipid Droplets, LC3 Recruitment, and Interaction with NTPase and NS4
Published in Viruses (01-03-2023)“…Human noroviruses (HuNVs) are the leading cause of gastroenteritis worldwide. NS1.2 is critical for HuNV pathogenesis, but the function is still unclear. The…”
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Subcellular Localization and Functional Characterization of GII.4 Norovirus-Encoded NTPase
Published in Journal of virology (01-03-2018)“…The genotype II.4 (GII.4) variants of human noroviruses (HuNVs) are recognized as the major agent of global gastroenteritis outbreaks. Due to the lack of an…”
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7
Identification of Location Specific Feature Points in a Cardiac Cycle Using a Novel Seismocardiogram Spectrum System
Published in IEEE journal of biomedical and health informatics (01-03-2018)“…Seismocardiogram (SCG) or mechanocardiography is a noninvasive cardiac diagnostic method; however, previous studies used only a single sensor to detect cardiac…”
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8
Regulation of autophagic activation by Rta of Epstein-Barr virus via the extracellular signal-regulated kinase pathway
Published in Journal of virology (01-10-2014)“…Autophagy is an intracellular degradation pathway that provides a host defense mechanism against intracellular pathogens. However, many viruses exploit this…”
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9
Effects of the NEDD8-Activating Enzyme Inhibitor MLN4924 on Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus
Published in Journal of virology (01-10-2017)“…The switch of Kaposi's sarcoma-associated herpesvirus (KSHV) from latency to lytic replication is a key event for viral dissemination and pathogenesis…”
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10
Regulation of the Abundance of Kaposi's Sarcoma-Associated Herpesvirus ORF50 Protein by Oncoprotein MDM2
Published in PLoS pathogens (01-10-2016)“…The switch between latency and the lytic cycle of Kaposi's sarcoma-associated herpesvirus (KSHV) is controlled by the expression of virally encoded ORF50…”
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11
Interaction Between BGLF2 and BBLF1 Is Required for the Efficient Production of Infectious Epstein-Barr Virus Particles
Published in Frontiers in microbiology (24-01-2020)“…BGLF2 is a tegument protein of the Epstein-Barr virus (EBV). This study finds that BGLF2 is expressed in the late stage of the EBV lytic cycle. Microscopic…”
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12
Interaction and assembly of the DNA replication core proteins of Kaposi's sarcoma-associated herpesvirus
Published in Microbiology spectrum (12-12-2023)“…Eukaryotic DNA replication is a highly regulated process that requires multiple replication enzymes assembled onto DNA replication origins. Due to the…”
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13
The rheology and extrusion processing performance of wood/melamine composites
Published in Journal of applied polymer science (05-02-2014)“…ABSTRACT A modified melamine resin that exhibits both thermoplastic and thermoset behaviors was used as a matrix for wood plastic composites (WPCs). The…”
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14
Brood success of sex-role-reversed pheasant-tailed jacanas: the effects of social polyandry, seasonality, and male mating order
Published in Zoological letters (30-04-2024)“…Multiple mating by avian females may increase hatching and overall brood success; however, reproductive effort and parental investment are costly, and females…”
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The N-terminal propeptide of type III procollagen in patients with acute coronary syndrome: a link between left ventricular end-diastolic pressure and cardiovascular events
Published in PloS one (05-01-2015)“…Despite the usefulness of N-terminal propeptide of type III procollagen (PIIINP) in detecting enhanced collagen turnover in patients with congestive heart…”
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Efficacy of portable sleep monitoring device in diagnosing central sleep apnea in patients with congestive heart failure
Published in Frontiers in neurology (21-12-2022)“…Central sleep apnea (CSA) is a common and serious comorbidity mainly occurring in patients with heart failure (HF), which tends to be underdiagnosed and has…”
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Identification and Characterization of Human Norovirus NTPase Regions Required for Lipid Droplet Localization, Cellular Apoptosis, and Interaction with the Viral P22 Protein
Published in Microbiology spectrum (03-09-2021)“…The human norovirus (HuNV)-encoded nucleoside-triphosphatase (NTPase) is a multifunctional protein critically involved in viral replication and pathogenesis…”
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18
Sex Role Reversal and High Frequency of Social Polyandry in the Pheasant-Tailed Jacana (Hydrophasianus chirurgus)
Published in Frontiers in ecology and evolution (03-11-2021)“…In a few species, males invest more than females in parental care while the females invest in mating competition and producing multiple broods for several…”
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Caspase-Mediated Cleavage of the Transcription Factor Sp3: Possible Relevance to Cancer and the Lytic Cycle of Kaposi's Sarcoma-Associated Herpesvirus
Published in Microbiology spectrum (23-02-2022)“…The open reading frame 50 (ORF50) protein of Kaposi's sarcoma-associated herpesvirus (KSHV) is the master regulator essential for initiating the viral lytic…”
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20
Relationship between Sugar Intake and Obesity among School-Age Children in Kaohsiung, Taiwan
Published in Journal of Nutritional Science and Vitaminology (2016)“…In recent years, the prevalence and problem of overweight and obesity in Taiwanese children have increased. There are many reports that the excessive intake of…”
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