Search Results - "Lee Murphy"

DNA methylation age of blood predicts all-cause mortality in later life by Marioni, Riccardo E, Shah, Sonia, McRae, Allan F, Chen, Brian H, Colicino, Elena, Harris, Sarah E, Gibson, Jude, Henders, Anjali K, Redmond, Paul, Cox, Simon R, Pattie, Alison, Corley, Janie, Murphy, Lee, Martin, Nicholas G, Montgomery, Grant W, Feinberg, Andrew P, Fallin, M Daniele, Multhaup, Michael L, Jaffe, Andrew E, Joehanes, Roby, Schwartz, Joel, Just, Allan C, Lunetta, Kathryn L, Murabito, Joanne M, Starr, John M, Horvath, Steve, Baccarelli, Andrea A, Levy, Daniel, Visscher, Peter M, Wray, Naomi R, Deary, Ian J

“…DNA methylation levels change with age. Recent studies have identified biomarkers of chronological age based on DNA methylation levels. It is not yet known…”
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Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach by Mendelson, Michael M, Marioni, Riccardo E, Joehanes, Roby, Liu, Chunyu, Hedman, Åsa K, Aslibekyan, Stella, Demerath, Ellen W, Guan, Weihua, Zhi, Degui, Yao, Chen, Huan, Tianxiao, Willinger, Christine, Chen, Brian, Courchesne, Paul, Multhaup, Michael, Irvin, Marguerite R, Cohain, Ariella, Schadt, Eric E, Grove, Megan L, Bressler, Jan, North, Kari, Sundström, Johan, Gustafsson, Stefan, Shah, Sonia, McRae, Allan F, Harris, Sarah E, Gibson, Jude, Redmond, Paul, Corley, Janie, Murphy, Lee, Starr, John M, Kleinbrink, Erica, Lipovich, Leonard, Visscher, Peter M, Wray, Naomi R, Krauss, Ronald M, Fallin, Daniele, Feinberg, Andrew, Absher, Devin M, Fornage, Myriam, Pankow, James S, Lind, Lars, Fox, Caroline, Ingelsson, Erik, Arnett, Donna K, Boerwinkle, Eric, Liang, Liming, Levy, Daniel, Deary, Ian J

“…The link between DNA methylation, obesity, and adiposity-related diseases in the general population remains uncertain. We conducted an association study of…”
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Identification of 55,000 Replicated DNA Methylation QTL by McRae, Allan F., Marioni, Riccardo E., Shah, Sonia, Yang, Jian, Powell, Joseph E., Harris, Sarah E., Gibson, Jude, Henders, Anjali K., Bowdler, Lisa, Painter, Jodie N., Murphy, Lee, Martin, Nicholas G., Starr, John M., Wray, Naomi R., Deary, Ian J., Visscher, Peter M., Montgomery, Grant W.

“…DNA methylation plays an important role in the regulation of transcription. Genetic control of DNA methylation is a potential candidate for explaining the many…”
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Utility of Whole-Genome Sequencing of Escherichia coli O157 for Outbreak Detection and Epidemiological Surveillance by Holmes, Anne, Allison, Lesley, Ward, Melissa, Dallman, Timothy J, Clark, Richard, Fawkes, Angie, Murphy, Lee, Hanson, Mary

“…Detailed laboratory characterization of Escherichia coli O157 is essential to inform epidemiological investigations. This study assessed the utility of…”
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Morning plasma cortisol as a cardiovascular risk factor: findings from prospective cohort and Mendelian randomization studies by Crawford, Andrew A, Soderberg, Stefan, Kirschbaum, Clemens, Murphy, Lee, Eliasson, Mats, Ebrahim, Shah, Davey Smith, George, Olsson, Tommy, Sattar, Naveed, Lawlor, Debbie A, Timpson, Nicolas J, Reynolds, Rebecca M, Walker, Brian R

“…Objective The identification of new causal risk factors has the potential to improve cardiovascular disease (CVD) risk prediction and the development of new…”
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Unplanned Extubation During Pediatric Cardiac Intensive Care: U.S. Multicenter Registry Study of Prevalence and Outcomes by Perry, Tanya, Klugman, Darren, Schumacher, Kurt, Banerjee, Mousumi, Zhang, Wenying, Bertrandt, Rebecca, Wolovits, Joshua S., Murphy, Lee D., Misfeldt, Andrew M., Alten, Jeffrey, Cooper, David S.

“…The epidemiology of unplanned extubations (UEs) and associated adverse outcomes in pediatric cardiac ICUs (CICU). Registry data (August 2014 to October 2020)…”
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Disparities in Adherence to Pediatric Diabetic Ketoacidosis Management Guidelines Across a Spectrum of Emergency Departments in the State of Indiana: An Observational In Situ Simulation-Based Study by Abulebda, Kamal, Abu-Sultaneh, Samer, White, Erin E, Kirby, Michele L, Phillips, Brian C, Frye, Courtney T, Murphy, Lee D, Lutfi, Riad

“…BACKGROUNDDiabetic ketoacidosis (DKA) is a common presentation to an emergency department (ED), with the majority presenting to community EDs. Adherence to…”
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Commentary: I am not throwing away my shot…to predict when your patient will decompensate by Murphy, Lee D., Cooper, David S., Mah, Kenneth E.

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Blood-based epigenome-wide analyses of 19 common disease states: A longitudinal, population-based linked cohort study of 18,413 Scottish individuals by Hillary, Robert F, McCartney, Daniel L, Smith, Hannah M, Bernabeu, Elena, Gadd, Danni A, Chybowska, Aleksandra D, Cheng, Yipeng, Murphy, Lee, Wrobel, Nicola, Campbell, Archie, Walker, Rosie M, Hayward, Caroline, Evans, Kathryn L, McIntosh, Andrew M, Marioni, Riccardo E

“…DNA methylation is a dynamic epigenetic mechanism that occurs at cytosine-phosphate-guanine dinucleotide (CpG) sites. Epigenome-wide association studies (EWAS)…”
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Unlocking the transcriptomic potential of formalin-fixed paraffin embedded clinical tissues: comparison of gene expression profiling approaches by Turnbull, Arran K, Selli, Cigdem, Martinez-Perez, Carlos, Fernando, Anu, Renshaw, Lorna, Keys, Jane, Figueroa, Jonine D, He, Xiaping, Tanioka, Maki, Munro, Alison F, Murphy, Lee, Fawkes, Angie, Clark, Richard, Coutts, Audrey, Perou, Charles M, Carey, Lisa A, Dixon, J Michael, Sims, Andrew H

“…High-throughput transcriptomics has matured into a very well established and widely utilised research tool over the last two decades. Clinical datasets…”
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De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands by Masalmeh, Roza H. Ali, Taglini, Francesca, Rubio-Ramon, Cristina, Musialik, Kamila I., Higham, Jonathan, Davidson-Smith, Hazel, Kafetzopoulos, Ioannis, Pawlicka, Kamila P., Finan, Hannah M., Clark, Richard, Wills, Jimi, Finch, Andrew J., Murphy, Lee, Sproul, Duncan

“…The aberrant gain of DNA methylation at CpG islands is frequently observed in colorectal tumours and may silence the expression of tumour suppressors such as…”
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High variability in cardiac education and experiences during United States paediatric critical care fellowships by Hanson, Amy E, Mastropietro, Christopher W, Murphy, Lee D, Rowan, Courtney M

“…Paediatric cardiac critical care continues to become more sub-specialised, and many institutions have transitioned to dedicated cardiac ICUs. Literature…”
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Refining epigenetic prediction of chronological and biological age by Bernabeu, Elena, McCartney, Daniel L, Gadd, Danni A, Hillary, Robert F, Lu, Ake T, Murphy, Lee, Wrobel, Nicola, Campbell, Archie, Harris, Sarah E, Liewald, David, Hayward, Caroline, Sudlow, Cathie, Cox, Simon R, Evans, Kathryn L, Horvath, Steve, McIntosh, Andrew M, Robinson, Matthew R, Vallejos, Catalina A, Marioni, Riccardo E

“…Epigenetic clocks can track both chronological age (cAge) and biological age (bAge). The latter is typically defined by physiological biomarkers and risk of…”
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Integration of datasets for individual prediction of DNA methylation-based biomarkers by Merzbacher, Charlotte, Ryan, Barry, Goldsborough, Thibaut, Hillary, Robert F, Campbell, Archie, Murphy, Lee, McIntosh, Andrew M, Liewald, David, Harris, Sarah E, McRae, Allan F, Cox, Simon R, Cannings, Timothy I, Vallejos, Catalina A, McCartney, Daniel L, Marioni, Riccardo E

“…Epigenetic scores (EpiScores) can provide biomarkers of lifestyle and disease risk. Projecting new datasets onto a reference panel is challenging due to…”
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Prospective Evaluation of Extubation Failure in Neonates and Infants After Cardiac Surgery by Hanson, Amy E, Herrmann, Jeremy L, Abu-Sultaneh, Samer, Murphy, Lee D, Mastropietro, Christopher W

“…Extubation failure and its associated complications are not uncommon after pediatric cardiac surgery, especially in neonates and young infants. We aimed to…”
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The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants by Crossman, Lisa C, Gould, Virginia C, Dow, J Maxwell, Vernikos, Georgios S, Okazaki, Aki, Sebaihia, Mohammed, Saunders, David, Arrowsmith, Claire, Carver, Tim, Peters, Nicholas, Adlem, Ellen, Kerhornou, Arnaud, Lord, Angela, Murphy, Lee, Seeger, Katharine, Squares, Robert, Rutter, Simon, Quail, Michael A, Rajandream, Mari-Adele, Harris, David, Churcher, Carol, Bentley, Stephen D, Parkhill, Julian, Thomson, Nicholas R, Avison, Matthew B

“…Stenotrophomonas maltophilia is a nosocomial opportunistic pathogen of the Xanthomonadaceae. The organism has been isolated from both clinical and soil…”
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Analysis of Patient Characteristics and Risk Factors for Thrombosis After Surgery for Congenital Heart Disease by Murphy, Lee D, Benneyworth, Brian D, Moser, Elizabeth A S, Hege, Kerry M, Valentine, Kevin M, Mastropietro, Christopher W

“…Thrombosis is a cause of morbidity in 4-15% of children who undergo pediatric cardiac surgery. Data on how to prevent this complication are sorely needed. We…”
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Deep Sedation in Pediatric Patients With Single Ventricle Physiology Outside of the Operating Room by Yabrodi, Mouhammad, Abdel-Mageed, Sarah, Abulebda, Kamal, Murphy, Lee D., Rodenbarger, Andrew, Bhai, Hamza, Lutfi, Riad, Friedman, Matthew L.

“…Background: Advancements in palliative surgery of patients with single ventricle physiology have led to an increase in the need for deep sedation protocols for…”
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Cardiac Arrest in Children Following Cardiac Surgery: A Scoping Review of Contributing Factors by Riley, Christine M., Murphy, Lee D., Mastropietro, Christopher W.

“…Nearly half of children experiencing cardiac arrest following cardiac surgery do not survive hospital discharge and patients who survive often experience…”
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Genetic analysis of the capsular biosynthetic locus from all 90 pneumococcal serotypes by Bentley, Stephen D, Aanensen, David M, Mavroidi, Angeliki, Saunders, David, Rabbinowitsch, Ester, Collins, Matthew, Donohoe, Kathy, Harris, David, Murphy, Lee, Quail, Michael A, Samuel, Gabby, Skovsted, Ian C, Kaltoft, Margit Staum, Barrell, Bart, Reeves, Peter R, Parkhill, Julian, Spratt, Brian G

“…Several major invasive bacterial pathogens are encapsulated. Expression of a polysaccharide capsule is essential for survival in the blood, and thus for…”
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