Search Results - "Lee, Young R."

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding by Turner, N., Kowalski, G. M., Leslie, S. J., Risis, S., Yang, C., Lee-Young, R. S., Babb, J. R., Meikle, P. J., Lancaster, G. I., Henstridge, D. C., White, P. J., Kraegen, E. W., Marette, A., Cooney, G. J., Febbraio, M. A., Bruce, C. R.

“…Aims/hypothesis While it is well known that diet-induced obesity causes insulin resistance, the precise mechanisms underpinning the initiation of insulin…”
Get full text

Clinical Outcomes of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae Infections with Susceptibilities among Levofloxacin, Cefepime, and Carbapenems by Walker, Kristy J., Klar, Amanda R., Lee, Young R.

“…Purpose. Highly resistant Gram-negative bacterial infections are associated with high mortality. Increasing resistance to standard therapy illustrates the need…”
Get full text

Impact of macrophage toll-like receptor 4 deficiency on macrophage infiltration into adipose tissue and the artery wall in mice by Coenen, K. R, Gruen, M. L, Lee-Young, R. S, Puglisi, M. J, Wasserman, D. H, Hasty, A. H

“…Aims/hypothesis Toll-like receptor 4 (TLR4) is a receptor for saturated fatty acids (SFAs), global deficiency of which has been shown to protect against…”
Get full text

Rate control with intravenous diltiazem, verapamil, and metoprolol in acute atrial fibrillation with rapid ventricular rate by Medeiros, Tia, Bui, Vi, Almekdash, Mhd Hasan, Keesari, Rohali, Lee, Young R

“…Introduction: Diltiazem is a preferred agent for rate control in atrial fibrillation due to its quick onset, minimal side effects, and low cost. Due to its…”
Get full text

Obesity impairs skeletal muscle AMPK signaling during exercise: role of AMPKα2 in the regulation of exercise capacity in vivo by Lee-Young, R.S, Ayala, J.E, Fueger, P.T, Mayes, W.H, Kang, L, Wasserman, D.H

“…Objective: Skeletal muscle AMP-activated protein kinase (AMPK)α2 activity is impaired in obese, insulin-resistant individuals during exercise. We determined…”
Get full text

Effect of exercise intensity and hypoxia on skeletal muscle AMPK signaling and substrate metabolism in humans by Wadley, G D, Lee-Young, R S, Canny, B J, Wasuntarawat, C, Chen, Z P, Hargreaves, M, Kemp, B E, McConell, G K

“…We compared in human skeletal muscle the effect of absolute vs. relative exercise intensity on AMP-activated protein kinase (AMPK) signaling and substrate…”
Get more information

AMP-activated protein kinase (AMPK)α2 plays a role in determining the cellular fate of glucose in insulin-resistant mouse skeletal muscle by Lee-Young, R. S., Bonner, J. S., Mayes, W. H., Iwueke, I., Barrick, B. A., Hasenour, C. M., Kang, L., Wasserman, D. H.

“…Aims/hypothesis We determined whether: (1) an acute lipid infusion impairs skeletal muscle AMP-activated protein kinase (AMPK)α2 activity, increases inducible…”
Get full text

Response to “Comment on: Cefiderocol, a New Siderophore Cephalosporin for the Treatment of Complicated Urinary Tract Infections Caused by Multidrug-Resistant Pathogens: Preclinical and Clinical Pharmacokinetics, Pharmacodynamics, Efficacy and Safety” by Lee, Young R.

Get full text

L-Arginine infusion increases glucose clearance during prolonged exercise in humans by McConell, G K, Huynh, N N, Lee-Young, R S, Canny, B J, Wadley, G D

“…Nitric oxide synthase (NOS) inhibition has been shown in humans to attenuate exercise-induced increases in muscle glucose uptake. We examined the effect of…”
Get more information

Response to Comment on: “Stratifying Therapeutic Enoxaparin Dose in Morbidly Obese Patients by BMI Class: A Retrospective Cohort Study” by Lee, Young R.

Get full text

Differential attenuation of AMPK activation during acute exercise following exercise training or AICAR treatment by McConell, G. K, Manimmanakorn, A, Lee-Young, R. S, Kemp, B. E, Linden, K. C, Wadley, G. D

“…1 Department of Physiology, The University of Melbourne, Melbourne, Victoria, Australia; 2 Department of Physiology, Khon Kaen University, Khon Kaen, Thailand;…”
Get full text

Meropenem-vaborbactam: a carbapenem and beta-lactamase inhibitor with activity against carbapenem-resistant Enterobacteriaceae by Lee, Young R., Baker, Nathaniel T.

“…Meropenem-vaborbactam is a carbapenem and β-lactamase inhibitor combination that is newly indicated for the treatment of complicated urinary tract infections…”
Get full text

Benefits of Beta-Blockade in Sepsis and Septic Shock: A Systematic Review by Lee, Young R., Seth, Michael Sadanand, Soney, Dylan, Dai, Hanyu

“…Background Sepsis and septic shock are inflammatory disorders associated with high rates of mortality. Patients with sepsis and septic shock frequently become…”
Get full text

Complicated Intra-Abdominal Infections: The Old Antimicrobials and the New Players by Lee, Young R., McMahan, Danni, McCall, Catherine, Perry, Gregory K.

“…Complicated intra-abdominal infections (cIAIs) are an important cause of morbidity and mortality worldwide. They are diagnosed when the initial abdominal organ…”
Get full text

Comparison of unfractionated heparin protocols using antifactor Xa monitoring or activated partial thrombin time monitoring by Frugé, Kristian S, Lee, Young R

“…OBJECTIVE.To determine whether there is a difference between an activated partial thromboplastin time (aPTT) based unfractionated heparin (UFH) protocol versus…”
Get full text

Stratifying Therapeutic Enoxaparin Dose in Morbidly Obese Patients by BMI Class: A Retrospective Cohort Study by Lee, Young R., Palmere, Peter J., Burton, Caitlin E., Benavides, Taylor M.

“…Background Enoxaparin is a low-molecular weight heparin (LMWH) commonly used for treatment of venous thromboembolism and acute coronary syndromes. The…”
Get full text

Efficacy of standard dose unfractionated heparin for venous thromboembolism prophylaxis in morbidly obese and non-morbidly obese critically Ill patients by Lee, Young R., Blanco, Delilah D.

“…To determine the efficacy of standard dose unfractionated heparin (UFH) for venous thromboembolism (VTE) prophylaxis in critically ill morbidly obese patients…”
Get full text

Continuous Infusion Versus Intermittent Bolus of Beta-Lactams in Critically Ill Patients with Respiratory Infections: A Systematic Review and Meta-analysis by Lee, Young R., Miller, Pamela D., Alzghari, Saeed K., Blanco, Delilah D., Hager, Jackson D., Kuntz, Kailey S.

“…Background Critically ill patients display altered pharmacokinetics and pharmacodynamics and are more likely to be infected with more resistant pathogens…”
Get full text

Monitoring Enoxaparin with Antifactor Xa Levels in Obese Patients by Lee, Young R., Vega, Jose A., Duong, Hanh-Nhi Q., Ballew, Austin

“…Study Objectives To characterize antifactor Xa peak levels (as therapeutic, subtherapeutic, and supratherapeutic) in morbidly obese patients receiving…”
Get full text

Clinical Characteristics and Patterns of Immune Responses in COVID-19 Patients From a Rural Community Hospital by La-Beck, Ninh M, Lee, Young R, Patel, Jalpa, Yang, Hui, Stout, Michal, Kologey, Alanna, Ruesewald, Amanda, Alvarez, Carlos A

“…Background Although demographic and clinical factors such as age, certain comorbidities, and sex have been associated with COVID-19 outcomes, these studies…”
Get full text