Search Results - "Lee, Yongchan"

Ion transfer mechanisms in Mrp-type antiporters from high resolution cryoEM and molecular dynamics simulations by Lee, Yongchan, Haapanen, Outi, Altmeyer, Anton, Kühlbrandt, Werner, Sharma, Vivek, Zickermann, Volker

“…Multiple resistance and pH adaptation (Mrp) cation/proton antiporters are essential for growth of a variety of halophilic and alkaliphilic bacteria under…”
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Structural basis for the facilitative diffusion mechanism by SemiSWEET transporter by Lee, Yongchan, Nishizawa, Tomohiro, Yamashita, Keitaro, Ishitani, Ryuichiro, Nureki, Osamu

“…SWEET family proteins mediate sugar transport across biological membranes and play crucial roles in plants and animals. The SWEETs and their bacterial…”
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Extracellular CIRP Induces Macrophage Extracellular Trap Formation Via Gasdermin D Activation by Lee, Yongchan, Reilly, Bridgette, Tan, Chuyi, Wang, Ping, Aziz, Monowar

“…Extracellular cold-inducible RNA-binding protein (eCIRP) is a damage-associated molecular pattern promoting inflammation and tissue injury. During bacterial or…”
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Extracellular CIRP promotes Kupffer cell inflammatory polarization in sepsis by Shimizu, Junji, Murao, Atsushi, Lee, Yongchan, Aziz, Monowar, Wang, Ping

“…Sepsis is a life-threatening inflammatory condition caused by dysregulated host responses to infection. Extracellular cold-inducible RNA-binding protein…”
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Free Energy Landscape for the Entire Transport Cycle of Triose-Phosphate/Phosphate Translocator by Takemoto, Mizuki, Lee, Yongchan, Ishitani, Ryuichiro, Nureki, Osamu

“…Secondary active transporters translocate their substrates using the electrochemical potentials of other chemicals and undergo large-scale conformational…”
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Neutrophil trogocytosis during their trans-endothelial migration: role of extracellular CIRP by Takizawa, Satoshi, Lee, Yongchan, Jacob, Asha, Aziz, Monowar, Wang, Ping

“…Neutrophils are the most abundant innate immune cells in the circulating blood, and they act as the first responder against bacterial and fungal infection…”
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The unique allosteric property of crocodilian haemoglobin elucidated by cryo-EM by Takahashi, Katsuya, Lee, Yongchan, Fago, Angela, Bautista, Naim M., Storz, Jay F., Kawamoto, Akihiro, Kurisu, Genji, Nishizawa, Tomohiro, Tame, Jeremy R. H.

“…The principal effect controlling the oxygen affinity of vertebrate haemoglobins (Hbs) is the allosteric switch between R and T forms with relatively high and…”
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Ca2+-mediated higher-order assembly of heterodimers in amino acid transport system b0,+ biogenesis and cystinuria by Lee, Yongchan, Wiriyasermkul, Pattama, Kongpracha, Pornparn, Moriyama, Satomi, Mills, Deryck J., Kühlbrandt, Werner, Nagamori, Shushi

“…Cystinuria is a genetic disorder characterized by overexcretion of dibasic amino acids and cystine, causing recurrent kidney stones and kidney failure…”
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In-cell infection： bringing uninvited guests by Lee, Yongchan, Overholtzer, Michael

“…Cell-in-cell structures resulting from live cell engulfment were iden- tified more than 100 years ago, but their physiological significance has remained…”
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Entosis Controls a Developmental Cell Clearance in C. elegans by Lee, Yongchan, Hamann, Jens C., Pellegrino, Mark, Durgan, Joanne, Domart, Marie-Charlotte, Collinson, Lucy M., Haynes, Cole M., Florey, Oliver, Overholtzer, Michael

“…Metazoan cell death mechanisms are diverse and include numerous non-apoptotic programs. One program called entosis involves the invasion of live cells into…”
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Structure of the triose-phosphate/phosphate translocator reveals the basis of substrate specificity by Lee, Yongchan, Nishizawa, Tomohiro, Takemoto, Mizuki, Kumazaki, Kaoru, Yamashita, Keitaro, Hirata, Kunio, Minoda, Ayumi, Nagatoishi, Satoru, Tsumoto, Kouhei, Ishitani, Ryuichiro, Nureki, Osamu

“…The triose-phosphate/phosphate translocator (TPT) catalyses the strict 1:1 exchange of triose-phosphate, 3-phosphoglycerate and inorganic phosphate across the…”
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Cutting Edge: Drebrin-Regulated Actin Dynamics Regulate IgE-Dependent Mast Cell Activation and Allergic Responses by Law, Mankit, Lee, YongChan, Morales, J Luis, Ning, Gang, Huang, Weishan, Pabon, Jonathan, Kannan, Arun K, Jeong, Ah-Reum, Wood, Amie, Carter, Chavez, Mohinta, Sonia, Song, Jihong, August, Avery

“…Mast cells play critical roles in allergic responses. Calcium signaling controls the function of these cells, and a role for actin in regulating calcium influx…”
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Enhanced Formation of Disulfide-bridged Dimer (Fab-PE38)2 Utilizing Repeats of the Fab Binding Domain of Protein G by Lee, YongChan, Park, JongChan, Kweon, SoonWook, Choe, MuHyeon

“…Fab-PE38 used in this study is B3(Fab)-ext-PE38, and it is an antibody toxin that is made by fusing the Pseudomonas exotoxin to the Fab domain of B3 antibody…”
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Natural Variation in Populations of Persistently Colonizing Bacteria Affect Human Host Cell Phenotype by Aras, Rahul A., Lee, Yongchan, Kim, Sung-Kook, Israel, Dawn, Peek, Richard M., Blaser, Martin J.

“…The highly diverse bacterium Helicobacter pylori which persistently colonizes the human stomach, provides models to study the role of genome plasticity in host…”
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After-Death Functions of Cell Death by Lee, Yongchan, Overholtzer, Michael

“…Cell death can occur through numerous regulated mechanisms, from apoptosis to necrosis, entosis, and others. Each has a distinct mode of regulation and effect…”
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Active Release of eCIRP via Gasdermin D Channels to Induce Inflammation in Sepsis by Tan, Chuyi, Reilly, Bridgette, Jha, Alok, Murao, Atsushi, Lee, Yongchan, Brenner, Max, Aziz, Monowar, Wang, Ping

“…Extracellular cold-inducible RNA binding protein (eCIRP) is an inflammatory mediator that causes inflammation and tissue injury in sepsis. Gasdermin D (GSDMD)…”
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Molecular dynamics simulations of a histidine switch in Mrp antiporter complex by Pecorilla, Cristina, Altmeyer, Anton, Haapanen, Outi, Lee, Yongchan, Zickermann, Volker, Sharma, Vivek

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Mutagenesis in the Mrp antiporter from Bacillus pseudofirmus identifies residues critical for the histidine switch mechanism by Altmeyer, Anton, Pecorilla, Cristina, Haapanen, Outi, Lee, Yongchan, Sharma, Vivek, Zickermann, Volker

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PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment by Krishna, Shefali, Palm, Wilhelm, Lee, Yongchan, Yang, Wendy, Bandyopadhyay, Urmi, Xu, Haoxing, Florey, Oliver, Thompson, Craig B., Overholtzer, Michael

“…The scavenging of extracellular macromolecules by engulfment can sustain cell growth in a nutrient-depleted environment. Engulfed macromolecules are contained…”
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Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc by Lee, Yongchan, Wiriyasermkul, Pattama, Jin, Chunhuan, Quan, Lili, Ohgaki, Ryuichi, Okuda, Suguru, Kusakizako, Tsukasa, Nishizawa, Tomohiro, Oda, Kazumasa, Ishitani, Ryuichiro, Yokoyama, Takeshi, Nakane, Takanori, Shirouzu, Mikako, Endou, Hitoshi, Nagamori, Shushi, Kanai, Yoshikatsu, Nureki, Osamu

“…The L-type amino acid transporter 1 (LAT1 or SLC7A5) transports large neutral amino acids across the membrane and is crucial for brain drug delivery and tumor…”
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