Search Results - "Lee, YiChien"
-
1
EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment
Published in Nature communications (20-06-2022)“…Differential outcomes of EphB4-ephrinB2 signaling offers formidable challenge for the development of cancer therapeutics. Here, we interrogate the effects of…”
Get full text
Journal Article -
2
Divergent brain changes in two audiogenic rat strains: A voxel-based morphometry and diffusion tensor imaging comparison of the genetically epilepsy prone rat (GEPR-3) and the Wistar Audiogenic Rat (WAR)
Published in Neurobiology of disease (01-03-2018)“…Acoustically evoked seizures (e.g., audiogenic seizures or AGS) are common in models of inherited epilepsy and occur in a variety of species including rat,…”
Get full text
Journal Article -
3
Empagliflozin Treatment Attenuates Hepatic Steatosis by Promoting White Adipose Expansion in Obese TallyHo Mice
Published in International journal of molecular sciences (18-05-2022)“…Sodium-glucose co-transporters (SGLTs) serve to reabsorb glucose in the kidney. Recently, these transporters, mainly SGLT2, have emerged as new therapeutic…”
Get full text
Journal Article -
4
Oral N-acetylcysteine decreases IFN-γ production and ameliorates ischemia-reperfusion injury in steatotic livers
Published in Frontiers in immunology (05-09-2022)“…Type 1 Natural Killer T-cells (NKT1 cells) play a critical role in mediating hepatic ischemia-reperfusion injury (IRI). Although hepatic steatosis is a major…”
Get full text
Journal Article -
5
Opening the Blood Brain Barrier with an Electropermanent Magnet System
Published in Pharmaceutics (20-07-2022)“…Opening the blood brain barrier (BBB) under imaging guidance may be useful for the treatment of many brain disorders. Rapidly applied magnetic fields have the…”
Get full text
Journal Article -
6
3367 A Mouse Model of APOE Genotype in Chemotherapy Related Cognitive Impairment
Published in Journal of clinical and translational science (01-03-2019)“…OBJECTIVES/SPECIFIC AIMS: Chemotherapy-related cognitive impairment (CRCI) affects 15-35% of breast cancer survivors and constitutes a significant challenge…”
Get full text
Journal Article -
7
VMY-1-103 is a novel CDK inhibitor that disrupts chromosome organization and delays metaphase progression in medulloblastoma cells
Published in Cancer biology & therapy (01-11-2011)“…Medulloblastoma is the most prevalent of childhood brain malignancies, constituting 25% of childhood brain tumors. Craniospinal radiotherapy is a standard of…”
Get full text
Journal Article -
8
Skilled reach training enhances robotic gait training to restore overground locomotion following spinal cord injury in rats
Published in Behavioural brain research (24-09-2021)“…•Robot assisted gait training partially reduced the locomotor deficits following a C4/5 overhemisection injury in rats.•Greater recovery was observed when…”
Get full text
Journal Article -
9
Abstract 667: A mouse model of APOE to define effects of doxorubicin on cognition
Published in Cancer research (Chicago, Ill.) (01-07-2019)“…The purpose of this study was to establish the effects of Apolipoprotein E (APOE) genotype on cognitive function following doxorubicin treatment in a mouse…”
Get full text
Journal Article -
10
Optical and magnetic resonance imaging approaches for investigating the tumour microenvironment: state-of-the-art review and future trends
Published in Nanotechnology (05-02-2021)“…The tumour microenvironment (TME) strongly influences tumorigenesis and metastasis. Two of the most characterized properties of the TME are acidosis and…”
Get more information
Journal Article -
11
Cerebral Creatine Deficiency Affects the Timing of Oligodendrocyte Myelination
Published in The Journal of neuroscience (15-02-2023)“…Cerebral creatine deficiency syndrome (CCDS) is an inborn error of metabolism characterized by intellectual delays, seizures, and autistic-like behavior…”
Get full text
Journal Article -
12
Development of a Human APOE Knock-in Mouse Model for Study of Cognitive Function After Cancer Chemotherapy
Published in Neurotoxicity research (01-02-2019)“…Cancer-related cognitive impairment in breast cancer patients exposed to multi-agent chemotherapy regimens is associated with the apolipoprotein E4 ( APOE4 )…”
Get full text
Journal Article -
13
The Sustained Induction of c-MYC Drives Nab-Paclitaxel Resistance in Primary Pancreatic Ductal Carcinoma Cells
Published in Molecular cancer research (01-09-2019)“…Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with limited and, very often, ineffective medical and surgical therapeutic options. The…”
Get full text
Journal Article -
14
Paramagnetic Mn 8 Fe 4 - co -Polystyrene Nanobeads as a Potential T 1 -T 2 Multimodal Magnetic Resonance Imaging Contrast Agent with In Vivo Studies
Published in ACS applied materials & interfaces (25-08-2021)“…In developing a cluster-nanocarrier design, as a magnetic resonance imaging contrast agent, we have investigated the enhanced relaxivity of a manganese and…”
Get full text
Journal Article -
15
Paramagnetic Mn8Fe4-co-Polystyrene Nanobeads as a Potential T1–T2 Multimodal Magnetic Resonance Imaging Contrast Agent with In Vivo Studies
Published in ACS applied materials & interfaces (25-08-2021)“…In developing a cluster-nanocarrier design, as a magnetic resonance imaging contrast agent, we have investigated the enhanced relaxivity of a manganese and…”
Get full text
Journal Article -
16
Paramagnetic Clusters of Mn3(O2CCH3)6(Bpy)2 in Polyacrylamide Nanobeads as a New Design Approach to a T1−T2 Multimodal Magnetic Resonance Imaging Contrast Agent
Published in ACS applied materials & interfaces (22-05-2019)“…There is an increasing need for gadolinium-free magnetic resonance imaging (MRI) contrast agents, particularly for patients suffering from chronic kidney…”
Get full text
Journal Article -
17
Abstract 1940: Prenatal stress increases malignancy of neuroblastoma tumors in TH-MYCN animal model
Published in Cancer research (Chicago, Ill.) (01-07-2017)“…Neuroblastoma (NB) is a pediatric malignancy arising due to defects in sympathetic neuron differentiation. NB is a heterogeneous disease, with phenotypes…”
Get full text
Journal Article -
18
-
19
Abstract 3291: Prenatal stress increases neuroblastoma tumorigenesis in TH-MYCN mice model
Published in Cancer research (Chicago, Ill.) (01-08-2015)“…Neuroblastomas (NB) are pediatric malignancies with heterogenous phenotypes, ranging from spontaneously regressing to highly aggressive, incurable tumors…”
Get full text
Journal Article -
20
Preclinical magnetic resonance imaging and systems biology in cancer research: current applications and challenges
Published in The American journal of pathology (01-02-2013)“…Biologically accurate mouse models of human cancer have become important tools for the study of human disease. The anatomical location of various target…”
Get full text
Journal Article